A0A0D8X138 · A0A0D8X138_LISMN

  • Protein
    Inosine-5'-monophosphate dehydrogenase
  • Gene
    guaB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

K+ (UniProtKB | Rhea| CHEBI:29103 )

Activity regulation

Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

Pathway

Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site251NAD+ (UniProtKB | ChEBI)
Binding site251-253NAD+ (UniProtKB | ChEBI)
Binding site301-303NAD+ (UniProtKB | ChEBI)
Binding site303K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain
Binding site305K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain
Binding site306IMP (UniProtKB | ChEBI)
Active site308Thioimidate intermediate
Binding site308K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain
Binding site341-343IMP (UniProtKB | ChEBI)
Binding site364-365IMP (UniProtKB | ChEBI)
Binding site388-392IMP (UniProtKB | ChEBI)
Active site404Proton acceptor
Binding site416IMP (UniProtKB | ChEBI)
Binding site470K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners
Binding site471K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners
Binding site472K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners

GO annotations

AspectTerm
Molecular FunctionIMP dehydrogenase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Biological ProcessGMP biosynthetic process
Biological ProcessGTP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosine-5'-monophosphate dehydrogenase
  • EC number
  • Short names
    IMP dehydrogenase
    ; IMPD
    ; IMPDH

Gene names

    • Name
      guaB
    • Synonyms
      guaB_1
    • ORF names
      A8L61_02390
      , AB917_00930
      , ABZ57_06290
      , AF817_11080
      , AJL21_06265
      , APD94_10250
      , ARR48_09220
      , ART25_08995
      , ARY78_08655
      , B1N52_05220
      , B1S26_06795
      , B5K54_01385
      , BB997_04740
      , BCZ19_07325
      , BCZ21_04025
      , BES38_09285
      , C9762_09315
      , CA369_00935
      , CAC64_06555
      , CAV64_06205
      , CD20_03135
      , CW845_03705
      , CW895_07945
      , D4271_07425
      , D4920_06250
      , D4B11_13720
      , D4C60_08690
      , D4D89_08115
      , D4U23_06715
      , D5M70_07560
      , D5N24_05595
      , D7104_04035
      , DCT16_04755
      , DG57_00880
      , DOV25_03845
      , DQ70_06085
      , DU018_11985
      , E0I39_08180
      , E1V33_04285
      , E1W43_06620
      , E1W56_06825
      , E1X78_06940
      , E5F58_11475
      , E5H26_11035
      , EC36_00175
      , EX365_08025
      , EXZ73_07190
      , F1788_09920
      , F6436_00905
      , F6515_07850
      , FA835_13820
      , FB15_01289
      , FC284_06445
      , FJU19_08020
      , FLQ97_12990
      , FLR03_09310
      , FNX40_00900
      , FPL45_03310
      , FV747_00875
      , FZW82_09410
      , G3O21_000179
      , G3R95_001834
      , GCV64_10795
      , GHH22_05720
      , GHO09_05780
      , GI230_08720
      , GI949_00915
      , GJW51_03715
      , GQG13_05190
      , GT011_11270
      , GYO01_09390
      , GYP27_03045
      , GYS09_09280
      , GYU24_11445
      , GYX23_00885
      , GYY14_03760
      , GZK27_09100
      , HQN34_001631
      , HZJ64_03895
      , IP987_002282
      , KV70_00900
      , QD52_05035
      , UI29_05030
      , Y261_03280

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 282333
    • 282352
    • 289003
    • 406731
    • 429821
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Listeriaceae > Listeria

Accessions

  • Primary accession
    A0A0D8X138

Proteomes

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain95-156CBS
Domain157-215CBS

Sequence similarities

Belongs to the IMPDH/GMPR family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    488
  • Mass (Da)
    52,556
  • Last updated
    2015-05-27 v1
  • Checksum
    91A6D0F6F8F9C3DB
MWETKFAKEGLTFDDVLLVPAKSDVLPNDVDLSVEMAPSLKLNVPIWSAGMDTITEAKMAIAIARQGGIGVVHKNMSIEQQAEEIEKVKRSESGVIIDPFYLTPDHQVFAAEHLMGKYRISGVPIVNNEKERKLVGILTNRDLRFISDYSTVIKDVMTKENLVTAPVGTTLKQAEQILQKHRIEKLPLVDEAGILKGLITIKDIEKVIEFPNSAKDKHGRLLAAAAVGITNDTFVRVEKLIEAGVDAIVIDTAHGHSAGVINKISEIRQTFKDVVIVAGNVATAEGARALFEVGVDIVKVGIGPGSICTTRVVAGVGVPQITAIYDCATVAREFGKTIIADGGIKYSGDIVKALAAGGNAVMLGSMLAGTDESPGETEIFQGRQFKTYRGMGSLAAMEHGSKDRYFQADAKKLVPEGIEGRVPYKGSVADIIFQLVGGIRSGMGYTGSPDLRHLREEAAFVRMTGAGLRESHPHDIQITKEAPNYSIS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAAIJX010000004
EMBL· GenBank· DDBJ
EAC4482864.1
EMBL· GenBank· DDBJ
Genomic DNA
AAAIKW010000003
EMBL· GenBank· DDBJ
EAC4552088.1
EMBL· GenBank· DDBJ
Genomic DNA
AAAIXK010000004
EMBL· GenBank· DDBJ
EAC5550496.1
EMBL· GenBank· DDBJ
Genomic DNA
AAAJKI010000035
EMBL· GenBank· DDBJ
EAC6549071.1
EMBL· GenBank· DDBJ
Genomic DNA
AAAJWF010000003
EMBL· GenBank· DDBJ
EAC7480246.1
EMBL· GenBank· DDBJ
Genomic DNA
AAAKQF010000001
EMBL· GenBank· DDBJ
EAC9038765.1
EMBL· GenBank· DDBJ
Genomic DNA
AAALRN010000002
EMBL· GenBank· DDBJ
EAD1184449.1
EMBL· GenBank· DDBJ
Genomic DNA
AAAMZD010000002
EMBL· GenBank· DDBJ
EAD3792139.1
EMBL· GenBank· DDBJ
Genomic DNA
AAANYN010000008
EMBL· GenBank· DDBJ
EAD5774080.1
EMBL· GenBank· DDBJ
Genomic DNA
AAANYR010000004
EMBL· GenBank· DDBJ
EAD5786499.1
EMBL· GenBank· DDBJ
Genomic DNA
AAAPCR010000002
EMBL· GenBank· DDBJ
EAD8145058.1
EMBL· GenBank· DDBJ
Genomic DNA
AAAQJJ010000001
EMBL· GenBank· DDBJ
EAE0768375.1
EMBL· GenBank· DDBJ
Genomic DNA
AAAQOE010000003
EMBL· GenBank· DDBJ
EAE1096340.1
EMBL· GenBank· DDBJ
Genomic DNA
AAAQQZ010000004
EMBL· GenBank· DDBJ
EAE1339039.1
EMBL· GenBank· DDBJ
Genomic DNA
AAAQVA010000003
EMBL· GenBank· DDBJ
EAE1631969.1
EMBL· GenBank· DDBJ
Genomic DNA
AAAREG010000002
EMBL· GenBank· DDBJ
EAE2353368.1
EMBL· GenBank· DDBJ
Genomic DNA
AAARIE010000003
EMBL· GenBank· DDBJ
EAE2659368.1
EMBL· GenBank· DDBJ
Genomic DNA
AAARLF010000003
EMBL· GenBank· DDBJ
EAE2897619.1
EMBL· GenBank· DDBJ
Genomic DNA
AAASLB010000003
EMBL· GenBank· DDBJ
EAE4941756.1
EMBL· GenBank· DDBJ
Genomic DNA
AAASTI010000003
EMBL· GenBank· DDBJ
EAE5603841.1
EMBL· GenBank· DDBJ
Genomic DNA
AABAGT010000003
EMBL· GenBank· DDBJ
EAG0866125.1
EMBL· GenBank· DDBJ
Genomic DNA
AABATR010000002
EMBL· GenBank· DDBJ
EAG1892912.1
EMBL· GenBank· DDBJ
Genomic DNA
AABAWE010000002
EMBL· GenBank· DDBJ
EAG2086414.1
EMBL· GenBank· DDBJ
Genomic DNA
AABAYG010000003
EMBL· GenBank· DDBJ
EAG2245113.1
EMBL· GenBank· DDBJ
Genomic DNA
AABBAW010000002
EMBL· GenBank· DDBJ
EAG2514552.1
EMBL· GenBank· DDBJ
Genomic DNA
AABBHO010000003
EMBL· GenBank· DDBJ
EAG2995942.1
EMBL· GenBank· DDBJ
Genomic DNA
AABBWO010000003
EMBL· GenBank· DDBJ
EAG4183971.1
EMBL· GenBank· DDBJ
Genomic DNA
AABBYJ010000003
EMBL· GenBank· DDBJ
EAG4330838.1
EMBL· GenBank· DDBJ
Genomic DNA
AABBZO010000001
EMBL· GenBank· DDBJ
EAG4460841.1
EMBL· GenBank· DDBJ
Genomic DNA
AABCVX010000002
EMBL· GenBank· DDBJ
EAG6168698.1
EMBL· GenBank· DDBJ
Genomic DNA
AABDDO010000003
EMBL· GenBank· DDBJ
EAG6763765.1
EMBL· GenBank· DDBJ
Genomic DNA
AABDGJ010000001
EMBL· GenBank· DDBJ
EAG6989158.1
EMBL· GenBank· DDBJ
Genomic DNA
AABEKN010000003
EMBL· GenBank· DDBJ
EAG9353738.1
EMBL· GenBank· DDBJ
Genomic DNA
AABEKY010000002
EMBL· GenBank· DDBJ
EAG9386588.1
EMBL· GenBank· DDBJ
Genomic DNA
AABEMN010000024
EMBL· GenBank· DDBJ
EAG9520828.1
EMBL· GenBank· DDBJ
Genomic DNA
AABEQV010000004
EMBL· GenBank· DDBJ
EAG9857067.1
EMBL· GenBank· DDBJ
Genomic DNA
AABEVI010000004
EMBL· GenBank· DDBJ
EAH0218277.1
EMBL· GenBank· DDBJ
Genomic DNA
AABEVT010000003
EMBL· GenBank· DDBJ
EAH0252078.1
EMBL· GenBank· DDBJ
Genomic DNA
AABFMV010000004
EMBL· GenBank· DDBJ
EAH1615234.1
EMBL· GenBank· DDBJ
Genomic DNA
AABFVG010000003
EMBL· GenBank· DDBJ
EAH2281665.1
EMBL· GenBank· DDBJ
Genomic DNA
AABGFX010000004
EMBL· GenBank· DDBJ
EAH3127158.1
EMBL· GenBank· DDBJ
Genomic DNA
AABGHY010000003
EMBL· GenBank· DDBJ
EAH3293862.1
EMBL· GenBank· DDBJ
Genomic DNA
AABGUK010000004
EMBL· GenBank· DDBJ
EAH4242605.1
EMBL· GenBank· DDBJ
Genomic DNA
AABGVJ010000003
EMBL· GenBank· DDBJ
EAH4373228.1
EMBL· GenBank· DDBJ
Genomic DNA
AACJYH010000003
EMBL· GenBank· DDBJ
EAK8896866.1
EMBL· GenBank· DDBJ
Genomic DNA
AACKDQ010000040
EMBL· GenBank· DDBJ
EAK9318174.1
EMBL· GenBank· DDBJ
Genomic DNA
AACKFB010000009
EMBL· GenBank· DDBJ
EAK9427976.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHZFN010000011
EMBL· GenBank· DDBJ
ECB9473868.1
EMBL· GenBank· DDBJ
Genomic DNA
AAHZFY010000035
EMBL· GenBank· DDBJ
ECB9514633.1
EMBL· GenBank· DDBJ
Genomic DNA
AAIAJJ010000001
EMBL· GenBank· DDBJ
ECC1555355.1
EMBL· GenBank· DDBJ
Genomic DNA
AAISWI010000003
EMBL· GenBank· DDBJ
ECH7210364.1
EMBL· GenBank· DDBJ
Genomic DNA
AAJEKY010000004
EMBL· GenBank· DDBJ
ECL0131037.1
EMBL· GenBank· DDBJ
Genomic DNA
AAKHCT010000003
EMBL· GenBank· DDBJ
ECR7123025.1
EMBL· GenBank· DDBJ
Genomic DNA
AALAQH010000003
EMBL· GenBank· DDBJ
ECX6924475.1
EMBL· GenBank· DDBJ
Genomic DNA
AALEDS010000001
EMBL· GenBank· DDBJ
ECY6542876.1
EMBL· GenBank· DDBJ
Genomic DNA
AALGDA010000019
EMBL· GenBank· DDBJ
ECY9782906.1
EMBL· GenBank· DDBJ
Genomic DNA
AAMGHX010000003
EMBL· GenBank· DDBJ
EDH0841569.1
EMBL· GenBank· DDBJ
Genomic DNA
AANCRK010000002
EMBL· GenBank· DDBJ
EDN7714520.1
EMBL· GenBank· DDBJ
Genomic DNA
AANCZP010000003
EMBL· GenBank· DDBJ
EDN8269921.1
EMBL· GenBank· DDBJ
Genomic DNA
AANDQG010000004
EMBL· GenBank· DDBJ
EDN9629675.1
EMBL· GenBank· DDBJ
Genomic DNA
AANDSR010000002
EMBL· GenBank· DDBJ
EDN9835772.1
EMBL· GenBank· DDBJ
Genomic DNA
AANEHK010000001
EMBL· GenBank· DDBJ
EDO0984550.1
EMBL· GenBank· DDBJ
Genomic DNA
AANOZB010000005
EMBL· GenBank· DDBJ
EDP8410272.1
EMBL· GenBank· DDBJ
Genomic DNA
AANPAU010000001
EMBL· GenBank· DDBJ
EDP8512787.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAEEB010000003
EMBL· GenBank· DDBJ
HAA8052654.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAEQL010000003
EMBL· GenBank· DDBJ
HAA8490005.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAHUJ010000004
EMBL· GenBank· DDBJ
HAB7364321.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAHYZ010000002
EMBL· GenBank· DDBJ
HAB7720944.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAIJL010000007
EMBL· GenBank· DDBJ
HAB8557483.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAIRR010000003
EMBL· GenBank· DDBJ
HAB9176320.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAJCS010000001
EMBL· GenBank· DDBJ
HAC0011542.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAJFY010000002
EMBL· GenBank· DDBJ
HAC0274484.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAJZA010000001
EMBL· GenBank· DDBJ
HAC1753532.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAKPP010000004
EMBL· GenBank· DDBJ
HAC3055660.1
EMBL· GenBank· DDBJ
Genomic DNA
DABJAN010000003
EMBL· GenBank· DDBJ
HAJ9593428.1
EMBL· GenBank· DDBJ
Genomic DNA
DABXZF010000026
EMBL· GenBank· DDBJ
HAO5923067.1
EMBL· GenBank· DDBJ
Genomic DNA
RCRQ01000002
EMBL· GenBank· DDBJ
MCO37577.1
EMBL· GenBank· DDBJ
Genomic DNA
JACAVN010000002
EMBL· GenBank· DDBJ
NYA00966.1
EMBL· GenBank· DDBJ
Genomic DNA
MJTJ01000013
EMBL· GenBank· DDBJ
OET50794.1
EMBL· GenBank· DDBJ
Genomic DNA
QAAO01000003
EMBL· GenBank· DDBJ
PXC49203.1
EMBL· GenBank· DDBJ
Genomic DNA
QUPY01000003
EMBL· GenBank· DDBJ
RKB98932.1
EMBL· GenBank· DDBJ
Genomic DNA
QUQJ01000001
EMBL· GenBank· DDBJ
RKC34814.1
EMBL· GenBank· DDBJ
Genomic DNA
VTHW01000002
EMBL· GenBank· DDBJ
TYU10676.1
EMBL· GenBank· DDBJ
Genomic DNA
CP098507
EMBL· GenBank· DDBJ
UUJ78556.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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