A0A0D8X138 · A0A0D8X138_LISMN
- ProteinInosine-5'-monophosphate dehydrogenase
- GeneguaB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids488 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
Catalytic activity
- IMP + NAD+ + H2O = XMP + NADH + H+
Cofactor
Activity regulation
Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
Pathway
Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 251 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 251-253 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 301-303 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 303 | K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain | |||
Binding site | 305 | K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain | |||
Binding site | 306 | IMP (UniProtKB | ChEBI) | |||
Active site | 308 | Thioimidate intermediate | |||
Binding site | 308 | K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain | |||
Binding site | 341-343 | IMP (UniProtKB | ChEBI) | |||
Binding site | 364-365 | IMP (UniProtKB | ChEBI) | |||
Binding site | 388-392 | IMP (UniProtKB | ChEBI) | |||
Active site | 404 | Proton acceptor | |||
Binding site | 416 | IMP (UniProtKB | ChEBI) | |||
Binding site | 470 | K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners | |||
Binding site | 471 | K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners | |||
Binding site | 472 | K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | IMP dehydrogenase activity | |
Molecular Function | metal ion binding | |
Molecular Function | nucleotide binding | |
Biological Process | GMP biosynthetic process | |
Biological Process | GTP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInosine-5'-monophosphate dehydrogenase
- EC number
- Short namesIMP dehydrogenase ; IMPD ; IMPDH
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Listeriaceae > Listeria
Accessions
- Primary accessionA0A0D8X138
Proteomes
Interaction
Subunit
Homotetramer.
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length488
- Mass (Da)52,556
- Last updated2015-05-27 v1
- Checksum91A6D0F6F8F9C3DB
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAAIJX010000004 EMBL· GenBank· DDBJ | EAC4482864.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAAIKW010000003 EMBL· GenBank· DDBJ | EAC4552088.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAAIXK010000004 EMBL· GenBank· DDBJ | EAC5550496.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAAJKI010000035 EMBL· GenBank· DDBJ | EAC6549071.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAAJWF010000003 EMBL· GenBank· DDBJ | EAC7480246.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAAKQF010000001 EMBL· GenBank· DDBJ | EAC9038765.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAALRN010000002 EMBL· GenBank· DDBJ | EAD1184449.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAAMZD010000002 EMBL· GenBank· DDBJ | EAD3792139.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAANYN010000008 EMBL· GenBank· DDBJ | EAD5774080.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAANYR010000004 EMBL· GenBank· DDBJ | EAD5786499.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAAPCR010000002 EMBL· GenBank· DDBJ | EAD8145058.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAAQJJ010000001 EMBL· GenBank· DDBJ | EAE0768375.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAAQOE010000003 EMBL· GenBank· DDBJ | EAE1096340.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAAQQZ010000004 EMBL· GenBank· DDBJ | EAE1339039.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAAQVA010000003 EMBL· GenBank· DDBJ | EAE1631969.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAAREG010000002 EMBL· GenBank· DDBJ | EAE2353368.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAARIE010000003 EMBL· GenBank· DDBJ | EAE2659368.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAARLF010000003 EMBL· GenBank· DDBJ | EAE2897619.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAASLB010000003 EMBL· GenBank· DDBJ | EAE4941756.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAASTI010000003 EMBL· GenBank· DDBJ | EAE5603841.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABAGT010000003 EMBL· GenBank· DDBJ | EAG0866125.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABATR010000002 EMBL· GenBank· DDBJ | EAG1892912.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABAWE010000002 EMBL· GenBank· DDBJ | EAG2086414.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABAYG010000003 EMBL· GenBank· DDBJ | EAG2245113.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABBAW010000002 EMBL· GenBank· DDBJ | EAG2514552.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABBHO010000003 EMBL· GenBank· DDBJ | EAG2995942.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABBWO010000003 EMBL· GenBank· DDBJ | EAG4183971.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABBYJ010000003 EMBL· GenBank· DDBJ | EAG4330838.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABBZO010000001 EMBL· GenBank· DDBJ | EAG4460841.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABCVX010000002 EMBL· GenBank· DDBJ | EAG6168698.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABDDO010000003 EMBL· GenBank· DDBJ | EAG6763765.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABDGJ010000001 EMBL· GenBank· DDBJ | EAG6989158.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABEKN010000003 EMBL· GenBank· DDBJ | EAG9353738.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABEKY010000002 EMBL· GenBank· DDBJ | EAG9386588.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABEMN010000024 EMBL· GenBank· DDBJ | EAG9520828.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABEQV010000004 EMBL· GenBank· DDBJ | EAG9857067.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABEVI010000004 EMBL· GenBank· DDBJ | EAH0218277.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABEVT010000003 EMBL· GenBank· DDBJ | EAH0252078.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABFMV010000004 EMBL· GenBank· DDBJ | EAH1615234.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABFVG010000003 EMBL· GenBank· DDBJ | EAH2281665.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABGFX010000004 EMBL· GenBank· DDBJ | EAH3127158.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABGHY010000003 EMBL· GenBank· DDBJ | EAH3293862.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABGUK010000004 EMBL· GenBank· DDBJ | EAH4242605.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AABGVJ010000003 EMBL· GenBank· DDBJ | EAH4373228.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AACJYH010000003 EMBL· GenBank· DDBJ | EAK8896866.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AACKDQ010000040 EMBL· GenBank· DDBJ | EAK9318174.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AACKFB010000009 EMBL· GenBank· DDBJ | EAK9427976.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHZFN010000011 EMBL· GenBank· DDBJ | ECB9473868.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAHZFY010000035 EMBL· GenBank· DDBJ | ECB9514633.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAIAJJ010000001 EMBL· GenBank· DDBJ | ECC1555355.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAISWI010000003 EMBL· GenBank· DDBJ | ECH7210364.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAJEKY010000004 EMBL· GenBank· DDBJ | ECL0131037.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAKHCT010000003 EMBL· GenBank· DDBJ | ECR7123025.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AALAQH010000003 EMBL· GenBank· DDBJ | ECX6924475.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AALEDS010000001 EMBL· GenBank· DDBJ | ECY6542876.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AALGDA010000019 EMBL· GenBank· DDBJ | ECY9782906.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAMGHX010000003 EMBL· GenBank· DDBJ | EDH0841569.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AANCRK010000002 EMBL· GenBank· DDBJ | EDN7714520.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AANCZP010000003 EMBL· GenBank· DDBJ | EDN8269921.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AANDQG010000004 EMBL· GenBank· DDBJ | EDN9629675.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AANDSR010000002 EMBL· GenBank· DDBJ | EDN9835772.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AANEHK010000001 EMBL· GenBank· DDBJ | EDO0984550.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AANOZB010000005 EMBL· GenBank· DDBJ | EDP8410272.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AANPAU010000001 EMBL· GenBank· DDBJ | EDP8512787.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAEEB010000003 EMBL· GenBank· DDBJ | HAA8052654.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAEQL010000003 EMBL· GenBank· DDBJ | HAA8490005.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAHUJ010000004 EMBL· GenBank· DDBJ | HAB7364321.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAHYZ010000002 EMBL· GenBank· DDBJ | HAB7720944.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAIJL010000007 EMBL· GenBank· DDBJ | HAB8557483.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAIRR010000003 EMBL· GenBank· DDBJ | HAB9176320.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAJCS010000001 EMBL· GenBank· DDBJ | HAC0011542.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAJFY010000002 EMBL· GenBank· DDBJ | HAC0274484.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAJZA010000001 EMBL· GenBank· DDBJ | HAC1753532.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DAAKPP010000004 EMBL· GenBank· DDBJ | HAC3055660.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABJAN010000003 EMBL· GenBank· DDBJ | HAJ9593428.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABXZF010000026 EMBL· GenBank· DDBJ | HAO5923067.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RCRQ01000002 EMBL· GenBank· DDBJ | MCO37577.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JACAVN010000002 EMBL· GenBank· DDBJ | NYA00966.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MJTJ01000013 EMBL· GenBank· DDBJ | OET50794.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QAAO01000003 EMBL· GenBank· DDBJ | PXC49203.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QUPY01000003 EMBL· GenBank· DDBJ | RKB98932.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QUQJ01000001 EMBL· GenBank· DDBJ | RKC34814.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
VTHW01000002 EMBL· GenBank· DDBJ | TYU10676.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP098507 EMBL· GenBank· DDBJ | UUJ78556.1 EMBL· GenBank· DDBJ | Genomic DNA |