A0A0D8HFN7 · A0A0D8HFN7_9ACTN

Function

function

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Note: Binds 1 Mg2+ ion per subunit. Can also utilize other divalent metal cations, such as Ca2+, Mn2+ and Co2+.
thiamine diphosphate (UniProtKB | Rhea| CHEBI:58937 )

Note: Binds 1 thiamine pyrophosphate per subunit.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site34substrate
Site34Important for catalytic activity
Binding site282substrate
Site282Important for catalytic activity
Binding site378substrate
Binding site405substrate
Binding site483substrate
Binding site491substrate
Binding site495substrate
Binding site542substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmagnesium ion binding
Molecular Functiontransketolase activity
Biological Processpentose-phosphate shunt

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Transketolase
  • EC number

Gene names

    • Name
      tkt2
    • ORF names
      AXFE_33290

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Py-F3
  • Taxonomic lineage
    Bacteria > Actinomycetota > Acidimicrobiia > Acidimicrobiales > Acidimicrobiaceae > Acidithrix

Accessions

  • Primary accession
    A0A0D8HFN7

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain375-547Transketolase-like pyrimidine-binding

Sequence similarities

Belongs to the transketolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    698
  • Mass (Da)
    75,721
  • Last updated
    2015-05-27 v1
  • Checksum
    35093F95631CB4EC
MTTTHRPSGDLDTISINTIRTLAIDAVEQANSGHPGTPMGMAPVGYQLWQYELNFDPADPLWPNRDRFVLSAGHASMLLYSLLHLAGVKAVNPAYETLGHASVTLEDIKTFRELGSRCPGHPEYRWTSGVETTTGPLGQGVANSVGMAISSAWLASRYNKPGFNLFDYKVYSLMGDGDMMEGISDEAASLAGHLGLSNLCWIYDNNKVTIEGPTALAFSEDVSSLFLGYGWNVTKVSDANDLSMLAKAFQVFRDETQRPTLIIVDSHIGFGAPDVQDTSAAHGAPLGAEEAKKAKHSYGWPENAKFLIPEGVYEHFAKGIGARGGELRAAWISLFADYERKHPTLAAEILAMQHRELPLHWDVDIPTFNSDPKGMATRESSGEVLNAIAPRVPWLLGGSADLTPSTLTHLTFAGAGDFEAADYNGRNLHFGIREHGAAAISSGLSLSKVRPYWSTFLVFSDYARGAIRLSALMEIPVIHIFTHDSIGMGQDGPTHQPIEQLASLRAIPGLIVLRPADANEVAEAWRVIMELQHNPVALVLTRQAVPTLDRSRYGSAKGVARGAYVLADPINGPPEAIVIATGSEVSLAIAAYEELSSQGIAVRVVSMPSCELFDRQPATYRDSVLPPEILARVAVEEASTFGWHRYVGIDGAVVGMHTFGASAPLKDLQNKFGFTPEKVADTIRQQLQTQLQNQRKNR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JXYS01000117
EMBL· GenBank· DDBJ
KJF15846.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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