A0A0D6KY72 · A0A0D6KY72_9CYAN

  • Protein
    tRNA-specific 2-thiouridylase MnmA
  • Gene
    mnmA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s2U34.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Features

Showing features for binding site, active site, site.

135150100150200250300350
Type
IDPosition(s)Description
Binding site7-14ATP (UniProtKB | ChEBI)
Binding site33ATP (UniProtKB | ChEBI)
Active site94Nucleophile
Binding site119ATP (UniProtKB | ChEBI)
Site120Interaction with tRNA
Active site193Cysteine persulfide intermediate
Site331Interaction with tRNA

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctiontRNA binding
Molecular FunctiontRNA-uridine 2-sulfurtransferase activity
Biological ProcesstRNA wobble position uridine thiolation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA-specific 2-thiouridylase MnmA
  • EC number

Gene names

    • Name
      mnmA
    • ORF names
      FDUTEX481_00822

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • PCC 7601 / UTEX B 481
  • Taxonomic lineage
    Bacteria > Cyanobacteriota > Cyanophyceae > Nostocales > Tolypothrichaceae > Tolypothrix

Accessions

  • Primary accession
    A0A0D6KY72

Proteomes

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region143-145Interaction with tRNA
Domain203-265tRNA-specific 2-thiouridylase MnmA-like central
Domain273-347tRNA-specific 2-thiouridylase MnmA-like C-terminal
Region298-299Interaction with tRNA

Sequence similarities

Belongs to the MnmA/TRMU family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    351
  • Mass (Da)
    38,437
  • Last updated
    2015-05-27 v1
  • Checksum
    2C34844F8F414144
MKKVVVGLSGGVDSSVAAAIIHNQGYEVIGLTLWLMKGKGQCCSEGMIDAANICEQLGIPHQVVDIRDVFQTNIVDYLVSGYSAGITPLPCSQCNKTVKFGPMVQYAREQLGCDRIATGHYARINYDQATGRYQLLRAIDRNKDQSYFLYDLSQDLLAATVFPLGEMQKADTRRIAAEYSLATADKPESQDLCLVESNGSMRAFLDKYLAPKTGDIVDTAGKVLGQHDGVHHYTIGQRKGLGIAAAEPLYVIELDAVNNRVVVGDRTKATQPECTVNRVNWVSIAEPSAPIHAEVQIRYRSQPTPVTVIPLENSRVRLVFDEPQFSITPGQAAVWYEGEKVLGGGIIEQFT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AGCR01000005
EMBL· GenBank· DDBJ
EKF04665.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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