A0A0D6KHI1 · A0A0D6KHI1_9CYAN

  • Protein
    Uracil phosphoribosyltransferase
  • Gene
    upp
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.

Activity regulation

Allosterically activated by GTP.

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site845-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site1095-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site137-1455-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site202uracil (UniProtKB | ChEBI)
Binding site207-209uracil (UniProtKB | ChEBI)
Binding site2085-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Molecular Functionuracil phosphoribosyltransferase activity
Biological ProcessUMP salvage
Biological Processuracil salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uracil phosphoribosyltransferase
  • EC number
  • Alternative names
    • UMP pyrophosphorylase
    • UPRTase

Gene names

    • Name
      upp
    • ORF names
      FDUTEX481_03744

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • PCC 7601 / UTEX B 481
  • Taxonomic lineage
    Bacteria > Cyanobacteriota > Cyanophyceae > Nostocales > Tolypothrichaceae > Tolypothrix

Accessions

  • Primary accession
    A0A0D6KHI1

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the UPRTase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    216
  • Mass (Da)
    23,414
  • Last updated
    2015-05-27 v1
  • Checksum
    16B14AF213BC494C
MTVQLRVYVPPHPLIKHWLAVARDAATPSVLFRSAMVELGRWLTYEAAREWLPTLETTVQSPLDTTAATFIDPQVPVAVVPILRAGLGLLEGAQTLLPLASIYHLGLVRNEETLQPSCYLNKLPEKFDPQTRVLITDPMLATGGSMMAAMSELIQRGVDPALIRIVCVVAAPPALQKLSVAYPSLNIYTATIDESVNEQGFIVPGLGDAGDRTFGT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AGCR01000081
EMBL· GenBank· DDBJ
EKE98827.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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