A0A0D6KFZ5 · A0A0D6KFZ5_9CYAN
- ProteinGlucose-6-phosphate 1-dehydrogenase
- Genezwf
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids509 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
Catalytic activity
- D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + H+ + NADPH
Pathway
Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 62 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 104-105 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: DI | ||||||
Binding site | 167 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 197 | substrate | ||||
Sequence: H | ||||||
Binding site | 201 | substrate | ||||
Sequence: K | ||||||
Binding site | 235 | substrate | ||||
Sequence: E | ||||||
Binding site | 254 | substrate | ||||
Sequence: D | ||||||
Active site | 259 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 359 | substrate | ||||
Sequence: K | ||||||
Binding site | 364 | substrate | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | glucose-6-phosphate dehydrogenase activity | |
Molecular Function | NADP binding | |
Biological Process | glucose metabolic process | |
Biological Process | pentose-phosphate shunt |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlucose-6-phosphate 1-dehydrogenase
- EC number
- Short namesG6PD
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Cyanobacteriota > Cyanophyceae > Nostocales > Tolypothrichaceae > Tolypothrix
Accessions
- Primary accessionA0A0D6KFZ5
Proteomes
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 25-206 | Glucose-6-phosphate dehydrogenase NAD-binding | ||||
Sequence: VIFGASGDLTWRKLVPALFKLRRERRIPPETTIVGVARREWSHDYFREQMQKGMQEAHSDVELGELWQDFSQGLFYCPGDIDNPESYQKLKNLLSELDEKRGTRGNRMFYLSVAPNFFPEAIKQLGGAGMLDDPYKHRLVIEKPFGRDLASAKSLNKVVQKYCKENQVYRIDHYLGKETVQN | ||||||
Domain | 208-507 | Glucose-6-phosphate dehydrogenase C-terminal | ||||
Sequence: LVFRFANAIFEPLWNRQFVDHVQITVAETVGVEDRAGYYEKAGALRDMLQNHLMQLYCLTAMEAPNAMDADSIRTEKVKVLQATRLAEVNNLSRAAVRGQYSAGWMKGQPVPGYREEPGVDPNSTTPTYVAMKFLVDNWRWQGVPFYLRTGKRMPKKVSEIAIHFRDVPSRMFQSAAQQRNANVLAMRIQPNEGISLRFDVKMPGAEFRTRSVDMDFSYGSFGIQATSDAYDRLFLDCMMGDQTLFTRADEVEAAWQVVTPALSVWDAPADPNTIPRYEAGTWEPAEAEFLINQDGRRWR |
Sequence similarities
Belongs to the glucose-6-phosphate dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length509
- Mass (Da)58,330
- Last updated2015-05-27 v1
- Checksum9C0661E4D978B007
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AGCR01000090 EMBL· GenBank· DDBJ | EKE98468.1 EMBL· GenBank· DDBJ | Genomic DNA |