A0A0D6HJL9 · A0A0D6HJL9_STAAU

  • Protein
    Elongation factor 4
  • Gene
    lepA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

Catalytic activity

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site23-28GTP (UniProtKB | ChEBI)
Binding site140-143GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionribosome binding
Molecular Functiontranslation elongation factor activity
Biological Processpositive regulation of translation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Elongation factor 4
  • EC number
  • Short names
    EF-4
  • Alternative names
    • Ribosomal back-translocase LepA

Gene names

    • Name
      lepA
    • Synonyms
      lepA_1
    • ORF names
      ACR74_00555
      , C0102_07365
      , CNH36_08485
      , EIG96_14035
      , EP54_13175
      , EQ90_02040
      , GO814_12835
      , GO942_05230
      , GQX37_10665
      , HMPREF3211_01735
      , NCTC13131_01906
      , SAMEA1029512_00512
      , SAMEA1029528_01624
      , SAMEA1029536_00472
      , SAMEA2078588_02758
      , SAMEA2080344_02726
      , SAMEA2081063_02771
      , SAMEA4008575_01403
      , SAMEA70146418_01085

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • CA15
    • M121
    • MRSA_S20
    • PSS7673
    • Newman
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus

Accessions

  • Primary accession
    A0A0D6HJL9
  • Secondary accessions
    • A0A1E8X1Q4

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain11-193Tr-type G

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    607
  • Mass (Da)
    68,175
  • Last updated
    2015-05-27 v1
  • Checksum
    9BCFFC5A06AAF6EB
MDNEQRLKRRENIRNFSIIAHIDHGKSTLADRILENTKSVETRDMQDQLLDSMDLERERGITIKLNAVRLKYEAKDGNTYTFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNELELLPVINKIDLPAAEPERVKQEIEDMIGLDQDDVVLASAKSNIGIEEILEKIVEVVPAPDGDPEAPLKALIFDSEYDPYRGVISSIRIVDGVVKAGDKIRMMATGKEFEVTEVGINTPKQLPVDELTVGDVGYIIASIKNVDDSRVGDTITLASRPASEPLQGYKKMNPMVYCGLFPIDNKNYNDLREALEKLQLNDASLEFEPESSQALGFGYRTGFLGMLHMEIIQERIEREFGIELIATAPSVIYQCVLRDGSEVTVDNPAQMPDRDKIDKIFEPYVRATMMVPNDYVGAVMELCQRKRGQFINMDYLDDIRVNIVYELPLAEVVFDFFDQLKSNTKGYASFDYEFIENKESNLVKMDILLNGDKVDALSFIVHRDFAYERGKALVEKLKTLIPRQQFEVPVQAAIGQKIVARTNIKSMGKNVLAKCYGGDISRKRKLLEKQKAGKAKMKAVGNVEIPQDAFLAVLKMDDE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP023391
EMBL· GenBank· DDBJ
ATC71695.1
EMBL· GenBank· DDBJ
Genomic DNA
CACTOE010000003
EMBL· GenBank· DDBJ
CAA4086686.1
EMBL· GenBank· DDBJ
Genomic DNA
CACTPG010000003
EMBL· GenBank· DDBJ
CAA4105498.1
EMBL· GenBank· DDBJ
Genomic DNA
CACTPI010000006
EMBL· GenBank· DDBJ
CAA4126559.1
EMBL· GenBank· DDBJ
Genomic DNA
CACTWD010000026
EMBL· GenBank· DDBJ
CAA4708352.1
EMBL· GenBank· DDBJ
Genomic DNA
CACUNS010000026
EMBL· GenBank· DDBJ
CAA6132079.1
EMBL· GenBank· DDBJ
Genomic DNA
CACURZ010000024
EMBL· GenBank· DDBJ
CAA6393939.1
EMBL· GenBank· DDBJ
Genomic DNA
CAIGXB010000004
EMBL· GenBank· DDBJ
CAC5791622.1
EMBL· GenBank· DDBJ
Genomic DNA
CAIIGD010000003
EMBL· GenBank· DDBJ
CAC8206992.1
EMBL· GenBank· DDBJ
Genomic DNA
UAUZ02000003
EMBL· GenBank· DDBJ
CAD7354366.1
EMBL· GenBank· DDBJ
Genomic DNA
LALJ01000004
EMBL· GenBank· DDBJ
KMR37862.1
EMBL· GenBank· DDBJ
Genomic DNA
LALQ01000069
EMBL· GenBank· DDBJ
KMR55962.1
EMBL· GenBank· DDBJ
Genomic DNA
LFVK01000001
EMBL· GenBank· DDBJ
KSA79108.1
EMBL· GenBank· DDBJ
Genomic DNA
LRQH01000133
EMBL· GenBank· DDBJ
KXA34949.1
EMBL· GenBank· DDBJ
Genomic DNA
WPTS01000037
EMBL· GenBank· DDBJ
MVK36027.1
EMBL· GenBank· DDBJ
Genomic DNA
WPXC01000010
EMBL· GenBank· DDBJ
MVM10089.1
EMBL· GenBank· DDBJ
Genomic DNA
JAANEC010000112
EMBL· GenBank· DDBJ
NUY12974.1
EMBL· GenBank· DDBJ
Genomic DNA
PKSU01000005
EMBL· GenBank· DDBJ
PZL80113.1
EMBL· GenBank· DDBJ
Genomic DNA
RQSX01000401
EMBL· GenBank· DDBJ
RZH90497.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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