A0A0D6HJL9 · A0A0D6HJL9_STAAU
- ProteinElongation factor 4
- GenelepA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids607 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.
Catalytic activity
- GTP + H2O = GDP + phosphate + H+
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 23-28 | GTP (UniProtKB | ChEBI) | |||
Binding site | 140-143 | GTP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Molecular Function | ribosome binding | |
Molecular Function | translation elongation factor activity | |
Biological Process | positive regulation of translation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameElongation factor 4
- EC number
- Short namesEF-4
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus
Accessions
- Primary accessionA0A0D6HJL9
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 11-193 | Tr-type G | |||
Sequence similarities
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length607
- Mass (Da)68,175
- Last updated2015-05-27 v1
- Checksum9BCFFC5A06AAF6EB
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP023391 EMBL· GenBank· DDBJ | ATC71695.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTOE010000003 EMBL· GenBank· DDBJ | CAA4086686.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTPG010000003 EMBL· GenBank· DDBJ | CAA4105498.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTPI010000006 EMBL· GenBank· DDBJ | CAA4126559.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTWD010000026 EMBL· GenBank· DDBJ | CAA4708352.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACUNS010000026 EMBL· GenBank· DDBJ | CAA6132079.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACURZ010000024 EMBL· GenBank· DDBJ | CAA6393939.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAIGXB010000004 EMBL· GenBank· DDBJ | CAC5791622.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAIIGD010000003 EMBL· GenBank· DDBJ | CAC8206992.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UAUZ02000003 EMBL· GenBank· DDBJ | CAD7354366.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LALJ01000004 EMBL· GenBank· DDBJ | KMR37862.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LALQ01000069 EMBL· GenBank· DDBJ | KMR55962.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LFVK01000001 EMBL· GenBank· DDBJ | KSA79108.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LRQH01000133 EMBL· GenBank· DDBJ | KXA34949.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WPTS01000037 EMBL· GenBank· DDBJ | MVK36027.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WPXC01000010 EMBL· GenBank· DDBJ | MVM10089.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAANEC010000112 EMBL· GenBank· DDBJ | NUY12974.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
PKSU01000005 EMBL· GenBank· DDBJ | PZL80113.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RQSX01000401 EMBL· GenBank· DDBJ | RZH90497.1 EMBL· GenBank· DDBJ | Genomic DNA |