A0A0D6H327 · A0A0D6H327_STAAU
- ProteinImidazolonepropionase
- GenehutI
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids412 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
Catalytic activity
- 4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate
Cofactor
Fe3+ (UniProtKB | Rhea| CHEBI:29034 )
Note: Binds 1 zinc or iron ion per subunit.
Pathway
Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 76 | Fe3+ (UniProtKB | ChEBI) | |||
Binding site | 76 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 78 | Fe3+ (UniProtKB | ChEBI) | |||
Binding site | 78 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 85 | 4-imidazolone-5-propanoate (UniProtKB | ChEBI) | |||
Binding site | 148 | 4-imidazolone-5-propanoate (UniProtKB | ChEBI) | |||
Binding site | 148 | N-formimidoyl-L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 181 | 4-imidazolone-5-propanoate (UniProtKB | ChEBI) | |||
Binding site | 242 | Fe3+ (UniProtKB | ChEBI) | |||
Binding site | 242 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 245 | 4-imidazolone-5-propanoate (UniProtKB | ChEBI) | |||
Binding site | 317 | Fe3+ (UniProtKB | ChEBI) | |||
Binding site | 317 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 319 | N-formimidoyl-L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 321 | N-formimidoyl-L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 322 | 4-imidazolone-5-propanoate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | imidazolonepropionase activity | |
Molecular Function | iron ion binding | |
Molecular Function | zinc ion binding | |
Biological Process | L-histidine catabolic process to glutamate and formamide | |
Biological Process | L-histidine catabolic process to glutamate and formate |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameImidazolonepropionase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus
Accessions
- Primary accessionA0A0D6H327
- Secondary accessions
Proteomes
Subcellular Location
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length412
- Mass (Da)45,039
- Last updated2015-05-27 v1
- Checksum9CBBB04A4EC54600
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP023391 EMBL· GenBank· DDBJ | ATC72504.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTOE010000006 EMBL· GenBank· DDBJ | CAA4107372.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTPG010000005 EMBL· GenBank· DDBJ | CAA4121676.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTPI010000008 EMBL· GenBank· DDBJ | CAA4138561.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTQT010000001 EMBL· GenBank· DDBJ | CAA4266818.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTWD010000008 EMBL· GenBank· DDBJ | CAA4684028.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACUNS010000002 EMBL· GenBank· DDBJ | CAA6048708.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACURZ010000002 EMBL· GenBank· DDBJ | CAA6314044.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAIGXB010000002 EMBL· GenBank· DDBJ | CAC5784029.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAIHOM010000003 EMBL· GenBank· DDBJ | CAC7013392.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAIIGD010000001 EMBL· GenBank· DDBJ | CAC8194810.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UAUZ02000002 EMBL· GenBank· DDBJ | CAD7354141.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LALJ01000003 EMBL· GenBank· DDBJ | KMR38199.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LALQ01000052 EMBL· GenBank· DDBJ | KMR56331.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LFVK01000004 EMBL· GenBank· DDBJ | KSA77330.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LRQH01000160 EMBL· GenBank· DDBJ | KXA33632.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAIUEN010000139 EMBL· GenBank· DDBJ | MCE3363270.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WPTS01000027 EMBL· GenBank· DDBJ | MVK35044.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WPXC01000004 EMBL· GenBank· DDBJ | MVM09379.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
PKSU01000003 EMBL· GenBank· DDBJ | PZL80765.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RQSX01000030 EMBL· GenBank· DDBJ | RZH96441.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UHBY01000003 EMBL· GenBank· DDBJ | SUL37638.1 EMBL· GenBank· DDBJ | Genomic DNA |