A0A0D5W888 · A0A0D5W888_9MONO
- ProteinPolymerase cofactor VP35
- GeneVP35
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids340 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | host cell cytoplasm | |
Cellular Component | virion component | |
Biological Process | symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity | |
Biological Process | symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity | |
Biological Process | symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity | |
Biological Process | symbiont-mediated suppression of host toll-like receptor signaling pathway |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended namePolymerase cofactor VP35
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Negarnaviricota > Haploviricotina > Monjiviricetes > Mononegavirales > Filoviridae > Orthoebolavirus > Orthoebolavirus zairense
Accessions
- Primary accessionA0A0D5W888
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for cross-link.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Cross-link | 309 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | |||
Keywords
- PTM
Interaction
Subunit
Homooligomer.
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-21 | Polar residues | |||
Region | 1-24 | Disordered | |||
Domain | 215-340 | VP35 IID | |||
Sequence similarities
Belongs to the filoviridae polymerase cofactor VP35 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length340
- Mass (Da)37,483
- Last updated2015-05-27 v1
- Checksum999F152D78F461FD
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-21 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KR006944 EMBL· GenBank· DDBJ | AJZ74553.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KR006947 EMBL· GenBank· DDBJ | AJZ74580.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KR006948 EMBL· GenBank· DDBJ | AJZ74589.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KR075003 EMBL· GenBank· DDBJ | AKC01490.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725254 EMBL· GenBank· DDBJ | ALG00872.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725273 EMBL· GenBank· DDBJ | ALG01043.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725277 EMBL· GenBank· DDBJ | ALG01079.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725283 EMBL· GenBank· DDBJ | ALG01133.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725284 EMBL· GenBank· DDBJ | ALG01142.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725285 EMBL· GenBank· DDBJ | ALG01151.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725286 EMBL· GenBank· DDBJ | ALG01160.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725288 EMBL· GenBank· DDBJ | ALG01178.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725289 EMBL· GenBank· DDBJ | ALG01187.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725296 EMBL· GenBank· DDBJ | ALG01250.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725301 EMBL· GenBank· DDBJ | ALG01295.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725303 EMBL· GenBank· DDBJ | ALG01313.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725304 EMBL· GenBank· DDBJ | ALG01322.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725322 EMBL· GenBank· DDBJ | ALG01484.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725323 EMBL· GenBank· DDBJ | ALG01493.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725324 EMBL· GenBank· DDBJ | ALG01502.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725327 EMBL· GenBank· DDBJ | ALG01529.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725330 EMBL· GenBank· DDBJ | ALG01556.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725331 EMBL· GenBank· DDBJ | ALG01565.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725336 EMBL· GenBank· DDBJ | ALG01610.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725341 EMBL· GenBank· DDBJ | ALG01655.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725342 EMBL· GenBank· DDBJ | ALG01664.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725344 EMBL· GenBank· DDBJ | ALG01682.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725352 EMBL· GenBank· DDBJ | ALG01754.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725355 EMBL· GenBank· DDBJ | ALG01781.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725370 EMBL· GenBank· DDBJ | ALG01916.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725372 EMBL· GenBank· DDBJ | ALG01934.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725378 EMBL· GenBank· DDBJ | ALG01988.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KT725388 EMBL· GenBank· DDBJ | ALG02078.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KU220284 EMBL· GenBank· DDBJ | ALT66792.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KU296436 EMBL· GenBank· DDBJ | ALX31874.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KU296610 EMBL· GenBank· DDBJ | ALX33014.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KX009894 EMBL· GenBank· DDBJ | AMT75591.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KX009895 EMBL· GenBank· DDBJ | AMT75600.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KX009900 EMBL· GenBank· DDBJ | AMT75645.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KX009904 EMBL· GenBank· DDBJ | AMT75681.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KX009908 EMBL· GenBank· DDBJ | AMT75717.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KX009910 EMBL· GenBank· DDBJ | AMT75735.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KX009911 EMBL· GenBank· DDBJ | AMT75744.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KY558984 EMBL· GenBank· DDBJ | AQS26703.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KY558986 EMBL· GenBank· DDBJ | AQS26721.1 EMBL· GenBank· DDBJ | Viral cRNA | ||
KY558988 EMBL· GenBank· DDBJ | AQS26739.1 EMBL· GenBank· DDBJ | Viral cRNA |