A0A0D5W888 · A0A0D5W888_9MONO

  • Protein
    Polymerase cofactor VP35
  • Gene
    VP35
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell cytoplasm
Cellular Componentvirion component
Biological Processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity
Biological Processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity
Biological Processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity
Biological Processsymbiont-mediated suppression of host toll-like receptor signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Polymerase cofactor VP35

Gene names

    • Name
      VP35
    • Synonyms
      vp35

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • Ebola virus/H.sapiens-wt/LBR/2014/Makona-LIBR0159
    • Ebola virus/H.sapiens-wt/LBR/2014/Makona-LIBR0350
    • Ebola virus/H.sapiens-wt/LBR/2014/Makona-LIBR0622
    • Ebola virus/H.sapiens-wt/LBR/2014/Makona-LIBR10100
    • Ebola virus/H.sapiens-wt/LBR/2014/Makona-LIBR10101
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Negarnaviricota > Haploviricotina > Monjiviricetes > Mononegavirales > Filoviridae > Orthoebolavirus > Orthoebolavirus zairense

Accessions

  • Primary accession
    A0A0D5W888

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for cross-link.

TypeIDPosition(s)Description
Cross-link309Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Keywords

Interaction

Subunit

Homooligomer.

Structure

3D structure databases

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias1-21Polar residues
Region1-24Disordered
Domain215-340VP35 IID

Sequence similarities

Belongs to the filoviridae polymerase cofactor VP35 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    340
  • Mass (Da)
    37,483
  • Last updated
    2015-05-27 v1
  • Checksum
    999F152D78F461FD
MTTRTKGRGHTVATTQNDRMPGPELSGWISEQLMTGRIPVNDIFCDIENNPGLCYASQMQQTKPNPKMRNSQTQTDPICNHSFEEVVQTLASLATVVQQQTIASESLEQRITSLENGLKPVYDMAKTISSLNRVCAEMVAKYDLLVMTTGRATATAAATEAYWAEHGQPPPGPSLYEESAIRGKIESRDETVPQSVREAFNNLDSTTSLTEENFGKPDISAKDLRNIMYDHLPGFGTAFHQLVQVICKFGKDSNSLDIIHAEFQASLAEGDSPQCALIQITKRVPIFQDAAPPVIHIRSRGDIPRACQKSLRPVPPSPKIDRGWVCVFQLQDGKTLGLKI

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-21Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KR006944
EMBL· GenBank· DDBJ
AJZ74553.1
EMBL· GenBank· DDBJ
Viral cRNA
KR006947
EMBL· GenBank· DDBJ
AJZ74580.1
EMBL· GenBank· DDBJ
Viral cRNA
KR006948
EMBL· GenBank· DDBJ
AJZ74589.1
EMBL· GenBank· DDBJ
Viral cRNA
KR075003
EMBL· GenBank· DDBJ
AKC01490.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725254
EMBL· GenBank· DDBJ
ALG00872.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725273
EMBL· GenBank· DDBJ
ALG01043.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725277
EMBL· GenBank· DDBJ
ALG01079.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725283
EMBL· GenBank· DDBJ
ALG01133.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725284
EMBL· GenBank· DDBJ
ALG01142.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725285
EMBL· GenBank· DDBJ
ALG01151.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725286
EMBL· GenBank· DDBJ
ALG01160.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725288
EMBL· GenBank· DDBJ
ALG01178.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725289
EMBL· GenBank· DDBJ
ALG01187.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725296
EMBL· GenBank· DDBJ
ALG01250.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725301
EMBL· GenBank· DDBJ
ALG01295.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725303
EMBL· GenBank· DDBJ
ALG01313.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725304
EMBL· GenBank· DDBJ
ALG01322.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725322
EMBL· GenBank· DDBJ
ALG01484.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725323
EMBL· GenBank· DDBJ
ALG01493.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725324
EMBL· GenBank· DDBJ
ALG01502.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725327
EMBL· GenBank· DDBJ
ALG01529.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725330
EMBL· GenBank· DDBJ
ALG01556.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725331
EMBL· GenBank· DDBJ
ALG01565.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725336
EMBL· GenBank· DDBJ
ALG01610.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725341
EMBL· GenBank· DDBJ
ALG01655.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725342
EMBL· GenBank· DDBJ
ALG01664.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725344
EMBL· GenBank· DDBJ
ALG01682.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725352
EMBL· GenBank· DDBJ
ALG01754.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725355
EMBL· GenBank· DDBJ
ALG01781.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725370
EMBL· GenBank· DDBJ
ALG01916.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725372
EMBL· GenBank· DDBJ
ALG01934.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725378
EMBL· GenBank· DDBJ
ALG01988.1
EMBL· GenBank· DDBJ
Viral cRNA
KT725388
EMBL· GenBank· DDBJ
ALG02078.1
EMBL· GenBank· DDBJ
Viral cRNA
KU220284
EMBL· GenBank· DDBJ
ALT66792.1
EMBL· GenBank· DDBJ
Viral cRNA
KU296436
EMBL· GenBank· DDBJ
ALX31874.1
EMBL· GenBank· DDBJ
Viral cRNA
KU296610
EMBL· GenBank· DDBJ
ALX33014.1
EMBL· GenBank· DDBJ
Viral cRNA
KX009894
EMBL· GenBank· DDBJ
AMT75591.1
EMBL· GenBank· DDBJ
Viral cRNA
KX009895
EMBL· GenBank· DDBJ
AMT75600.1
EMBL· GenBank· DDBJ
Viral cRNA
KX009900
EMBL· GenBank· DDBJ
AMT75645.1
EMBL· GenBank· DDBJ
Viral cRNA
KX009904
EMBL· GenBank· DDBJ
AMT75681.1
EMBL· GenBank· DDBJ
Viral cRNA
KX009908
EMBL· GenBank· DDBJ
AMT75717.1
EMBL· GenBank· DDBJ
Viral cRNA
KX009910
EMBL· GenBank· DDBJ
AMT75735.1
EMBL· GenBank· DDBJ
Viral cRNA
KX009911
EMBL· GenBank· DDBJ
AMT75744.1
EMBL· GenBank· DDBJ
Viral cRNA
KY558984
EMBL· GenBank· DDBJ
AQS26703.1
EMBL· GenBank· DDBJ
Viral cRNA
KY558986
EMBL· GenBank· DDBJ
AQS26721.1
EMBL· GenBank· DDBJ
Viral cRNA
KY558988
EMBL· GenBank· DDBJ
AQS26739.1
EMBL· GenBank· DDBJ
Viral cRNA

Similar Proteins

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