A0A0D5NDX9 · A0A0D5NDX9_9BACL

  • Protein
    Dihydroorotate dehydrogenase (quinone)
  • Gene
    pyrD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the conversion of dihydroorotate to orotate with NAD+ as electron acceptor.
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

Catalytic activity

Cofactor

FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (NAD+ route): step 1/1.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site69-73FMN (UniProtKB | ChEBI)
Binding site73substrate
Binding site93FMN (UniProtKB | ChEBI)
Binding site118-122substrate
Binding site147FMN (UniProtKB | ChEBI)
Binding site180FMN (UniProtKB | ChEBI)
Binding site180substrate
Active site183Nucleophile
Binding site185substrate
Binding site226FMN (UniProtKB | ChEBI)
Binding site254FMN (UniProtKB | ChEBI)
Binding site255-256substrate
Binding site276FMN (UniProtKB | ChEBI)
Binding site305FMN (UniProtKB | ChEBI)
Binding site326-327FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Molecular Functiondihydroorotate dehydrogenase (NAD+) activity
Molecular Functiondihydroorotate dehydrogenase (quinone) activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotate dehydrogenase (quinone)
  • EC number
  • Alternative names
    • DHOdehase
      (DHOD
      ; DHODase
      )
    • Dihydroorotate oxidase

Gene names

    • Name
      pyrD
    • ORF names
      VN24_00365

Organism names

  • Taxonomic identifier
  • Strain
    • DSM 24997
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Paenibacillaceae > Paenibacillus

Accessions

  • Primary accession
    A0A0D5NDX9

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

Interaction

Subunit

Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain52-348Dihydroorotate dehydrogenase catalytic

Sequence similarities

Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    365
  • Mass (Da)
    39,368
  • Last updated
    2015-05-27 v1
  • Checksum
    EE79A50F1C98A8C0
MLYTSLLKPALFRMDPEKAHHLVIDGLSAAGRIPGTTGLLHALYGVPNYPELAVNLFGLQFSHPVGLAAGLDKNAKVGDIFRNIGFSFAEMGTVTPKAQAGNELPRLFRLPPDEALINRMGFNNDGADAMAQRLSAGRKRSIPIAVNIGKNKTTPNEEAHLDYRKCLEKLYPFGDFFVVNISSPNTPDLRALQHGGELRTLLSEVLEEMGIQAARSGSKRKPVLVKIAPDMTDEQLELTIDTIAASGVDGLIATNTTLSRDGLTHRNAGETGGLSGKPLKARSTEIVAAVYKQTGGKLPIIGSGGIFNADDAYDKIRAGASMVEIYTALIYRGPEVLKELTSGLRERLRRDGFMQVTEAIGADHH

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP011058
EMBL· GenBank· DDBJ
AJY73360.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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