A0A0D4CD66 · A0A0D4CD66_BRELC

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Cu cation (UniProtKB | Rhea| CHEBI:23378 )

Note: Binds a copper A center.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespirasome
Molecular Functioncopper ion binding
Molecular Functioncytochrome-c oxidase activity
Biological ProcessATP synthesis coupled electron transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 2

Gene names

    • Name
      cox2

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    A0A0D4CD66

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane15-35Helical
Transmembrane56-78Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-84Cytochrome oxidase subunit II transmembrane region profile
Domain85-179Cytochrome oxidase subunit II copper A binding

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    179
  • Mass (Da)
    20,437
  • Last updated
    2015-05-27 v1
  • Checksum
    3FA30A6AE293D24B
ATPVMEGIINFHHDIMFFLIMITIFVCWMLFRVVTLFDEKINKVPATIVHGATIEIIWTLIPALILLIVAVPSFALLYSMDEIIDPIITLKVIGSQWYWSYEYSDNLEFSDEPLIFDSYMVQEDDLAIGQFRLLEVDNRVIVPTNSHIRVLITASDVLHSWAIPSLGIKLDACPGRLNQ

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue179

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KP684810
EMBL· GenBank· DDBJ
AJT47027.1
EMBL· GenBank· DDBJ
Genomic DNA
KP684816
EMBL· GenBank· DDBJ
AJT47033.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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