A0A0D3Q2S7 · A0A0D3Q2S7_SPIER

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespirasome
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processoxidative phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      cox1

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    A0A0D3Q2S7

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-44Helical
Transmembrane65-86Helical
Transmembrane106-124Helical
Transmembrane145-173Helical
Transmembrane185-211Helical
Transmembrane243-262Helical
Transmembrane268-289Helical
Transmembrane301-326Helical
Transmembrane338-364Helical
Transmembrane371-397Helical
Transmembrane409-427Helical
Transmembrane448-474Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-493Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    521
  • Mass (Da)
    58,560
  • Last updated
    2015-05-27 v1
  • Checksum
    495D0A26DF2E6536
MAKFSFFSWLFTLDHKRVGMIYTLIGIWSGFVGLSFSVMIRVNFVEPYFNVISSDCYNFLITNHGIIMIFFFLMPGLMGGLGNYLIPLLPGLPNLNFPRLNPLNAGWLFPPILFLGLSSGWGAGNGGTFYPPLSSSLFSNSRGANLLMFSLLLAGLSSLWGSINFICTLYSAFVDNFVSRSSILLWSYLFTSILLWLTIPVWAAAITMLLFDRNFGSAFFDPLGGGDPVLFQHMFWFFGHPEVYVLILPGFGMVSHVCSNLGCSYDTFGFYGLLFAMFSIVCLGSVVWGHHMFTVGLDVKTAVFFSSVTMIIGVPTGIKVFSWLYMILNSRVSLREPVFWWVLSFIVLFTMGGVTGIILSACVLDNILHDTWFVVAHFHYVMSLGSYISVIIFFVWWWPVITGVSLNKYLLQCHCIVSNVGFNLCFFPMHYFGICGLPRRVCVYESGYAWVNMLCSIGSFVSAFSGCFFIFILWESLANKNVVIGYYGNSSTLLNLCWSPVPYHSNFFVRGLFVDYSVLAF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KM605284
EMBL· GenBank· DDBJ
AJC01973.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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