A0A0D3ML63 · A0A0D3ML63_9TELE
- Proteinreceptor protein-tyrosine kinase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids688 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 370-376 | ATP (UniProtKB | ChEBI) | ||||
Sequence: LGEGCFG | ||||||
Binding site | 400 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 448-450 | ATP (UniProtKB | ChEBI) | ||||
Sequence: EFA | ||||||
Binding site | 454 | ATP (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Active site | 509 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 513 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 527 | ATP (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasmic vesicle | |
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Cellular Component | receptor complex | |
Molecular Function | ATP binding | |
Molecular Function | fibroblast growth factor binding | |
Molecular Function | fibroblast growth factor receptor activity | |
Biological Process | positive regulation of cell population proliferation | |
Biological Process | positive regulation of kinase activity | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namereceptor protein-tyrosine kinase
- EC number
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Cyprinidae > Schizothoracinae > Schizothorax
Accessions
- Primary accessionA0A0D3ML63
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 263-283 | Helical | ||||
Sequence: VLIYCVGFFLICVMVVTAVLA |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 66↔118 | |||||
Sequence: CQANGNPTPTLKWLKNSKEFKKDQRIGGYKVREHMWTIIMESVVPSDKGNYTC | ||||||
Disulfide bond | 165↔229 | |||||
Sequence: CKVFSDPQPHIQWLKHIEVNGSRVGPDGLPYVRILKTAGINTTDKEMEVLQIRNVSLEDSGEYTC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-37 | Disordered | ||||
Sequence: SDYFSVNVTDGLVSSEDDEEDESSSEETKLSSDQKLL | ||||||
Domain | 46-134 | Ig-like | ||||
Sequence: PDKMEKKLHAVPASKTVKFRCQANGNPTPTLKWLKNSKEFKKDQRIGGYKVREHMWTIIMESVVPSDKGNYTCLVENKYGSINHTYQLD | ||||||
Domain | 143-245 | Ig-like | ||||
Sequence: PILQAGLPANRTVVVGSDVEFECKVFSDPQPHIQWLKHIEVNGSRVGPDGLPYVRILKTAGINTTDKEMEVLQIRNVSLEDSGEYTCLAGNSIGHSHHSAWLT | ||||||
Domain | 364-653 | Protein kinase | ||||
Sequence: LVLGKPLGEGCFGQVMMAEAIGMDKDKPSRVTKVAVKMLKSDATEKDLSDLISEMEMMKIIGKHKNIINLLGACTQDGPLYVIVEFAAKGNLREYLRVRRPPGMEYCYNPDQVPVENMSSKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDRPSTCTHELYMMMRDCWHAVPSQRPTFKQLVEDLDRTLCMTSNQEYL | ||||||
Region | 669-688 | Disordered | ||||
Sequence: TRSSTCSSGEGSVFSHDPGS |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length688
- Mass (Da)77,173
- Last updated2015-05-27 v1
- Checksum842AB9B0B88576A7
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: S | ||||||
Non-terminal residue | 688 | |||||
Sequence: S |