A0A0D3MKX6 · A0A0D3MKX6_9STRA
- ProteinFerredoxin-thioredoxin reductase, catalytic chain
- GeneftrB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids102 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.
Catalytic activity
- [thioredoxin]-disulfide + 2 H+ + 2 reduced [2Fe-2S]-[ferredoxin] = [thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin]
RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ 2 CHEBI:15378 + 2 RHEA-COMP:10001 = RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3+ 2 RHEA-COMP:10000
Cofactor
Note: Binds 1 [4Fe-4S] cluster.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 52 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Active site | 54 | Nucleophile | ||||
Sequence: C | ||||||
Binding site | 71 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 73 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 82 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Site | 83 | Increases the nucleophilicity of the active site Cys | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plastid | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | ferredoxin-thioredoxin reductase activity | |
Molecular Function | metal ion binding | |
Molecular Function | oxidoreductase activity, acting on iron-sulfur proteins as donors |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFerredoxin-thioredoxin reductase, catalytic chain
- EC number
- Short namesFTR-C
- Alternative names
Gene names
Encoded on
- Plastid
Organism names
- Organism
- Taxonomic lineageEukaryota > Sar > Stramenopiles > Ochrophyta > Chrysophyceae > Chromulinales > Chromulinaceae > Ochromonas
Accessions
- Primary accessionA0A0D3MKX6
Subcellular Location
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 54↔84 | Redox-active | ||||
Sequence: CRYYDNKEDEISLAYWNCPCVPMRERKECHC |
Keywords
- PTM
Interaction
Subunit
Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.
Structure
Sequence
- Sequence statusComplete
- Length102
- Mass (Da)11,814
- Last updated2015-05-27 v1
- Checksum6E2DB26BB1714BEF