A0A0D3M790 · A0A0D3M790_9MUSC

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Opomyzoidea > Agromyzidae > Phytomyzinae > Liriomyza

Accessions

  • Primary accession
    A0A0D3M790

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-25Helical
Transmembrane37-66Helical
Transmembrane86-106Helical
Transmembrane127-155Helical
Transmembrane167-194Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-210Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    210
  • Mass (Da)
    22,489
  • Last updated
    2015-05-27 v1
  • Checksum
    05F72C40E7484851
TLYFMFGAWAGMVGTSLSILIRAELGHPGALIGDDQIYNVIVTAHAFIMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPALTLLLMSSMVENGAGTGWTVYPPLSSIIAHGGASVDLAIFSLHLAGISSILGAVNFITTIINMRSTGISFDRMPLFVWSVLITAILLLLSLPVLAGAITMLLTDRNFNTSFFDPAGGG

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue210

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KJ637625
EMBL· GenBank· DDBJ
AID15756.1
EMBL· GenBank· DDBJ
Genomic DNA
KM863745
EMBL· GenBank· DDBJ
ALH10088.1
EMBL· GenBank· DDBJ
Genomic DNA
KM863774
EMBL· GenBank· DDBJ
ALH10117.1
EMBL· GenBank· DDBJ
Genomic DNA
KM865666
EMBL· GenBank· DDBJ
ALH12009.1
EMBL· GenBank· DDBJ
Genomic DNA
KM866567
EMBL· GenBank· DDBJ
ALH12910.1
EMBL· GenBank· DDBJ
Genomic DNA
KM867130
EMBL· GenBank· DDBJ
ALH13473.1
EMBL· GenBank· DDBJ
Genomic DNA
KM854750
EMBL· GenBank· DDBJ
ALK53410.1
EMBL· GenBank· DDBJ
Genomic DNA
KM857094
EMBL· GenBank· DDBJ
ALK55752.1
EMBL· GenBank· DDBJ
Genomic DNA
KM857146
EMBL· GenBank· DDBJ
ALK55804.1
EMBL· GenBank· DDBJ
Genomic DNA
KM858104
EMBL· GenBank· DDBJ
ALK56762.1
EMBL· GenBank· DDBJ
Genomic DNA
KY843692
EMBL· GenBank· DDBJ
ASB25212.1
EMBL· GenBank· DDBJ
Genomic DNA
MF638726
EMBL· GenBank· DDBJ
AVM34480.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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