A0A0D3L3N8 · A0A0D3L3N8_9CHIR
- ProteinMalate dehydrogenase
- GeneMDH1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids238 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS).
Catalytic activity
- (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH + H+This reaction proceeds in the backward direction.
- (S)-2-hydroxyglutarate + NAD+ = 2-oxoglutarate + NADH + H+This reaction proceeds in the backward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | mitochondrion | |
Molecular Function | hydroxyphenylpyruvate reductase activity | |
Molecular Function | L-malate dehydrogenase (NAD+) activity | |
Biological Process | malate metabolic process | |
Biological Process | NADH metabolic process | |
Biological Process | oxaloacetate metabolic process | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMalate dehydrogenase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yinpterochiroptera > Rhinolophoidea > Hipposideridae > Hipposideros
Accessions
- Primary accessionA0A0D3L3N8
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 6-120 | Lactate/malate dehydrogenase N-terminal | |||
Domain | 124-237 | Lactate/malate dehydrogenase C-terminal | |||
Sequence similarities
Belongs to the LDH/MDH superfamily. MDH type 2 family.
Family and domain databases
Sequence
- Sequence statusFragment
- Length238
- Mass (Da)25,974
- Last updated2015-05-27 v1
- MD5 ChecksumBA11BDC8AFD9CE0569EB9EF0C58077CD
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 238 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JQ735081 EMBL· GenBank· DDBJ | AFJ54470.1 EMBL· GenBank· DDBJ | mRNA |