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A0A0D3L3N8 · A0A0D3L3N8_9CHIR

  • Protein
    Malate dehydrogenase
  • Gene
    MDH1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS).

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmitochondrion
Molecular Functionhydroxyphenylpyruvate reductase activity
Molecular FunctionL-malate dehydrogenase (NAD+) activity
Biological Processmalate metabolic process
Biological ProcessNADH metabolic process
Biological Processoxaloacetate metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Malate dehydrogenase
  • EC number

Gene names

    • Name
      MDH1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Zt
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yinpterochiroptera > Rhinolophoidea > Hipposideridae > Hipposideros

Accessions

  • Primary accession
    A0A0D3L3N8

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-120Lactate/malate dehydrogenase N-terminal
Domain124-237Lactate/malate dehydrogenase C-terminal

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 2 family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    238
  • Mass (Da)
    25,974
  • Last updated
    2015-05-27 v1
  • MD5 Checksum
    BA11BDC8AFD9CE0569EB9EF0C58077CD
DQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEEVAFKDLDVAILVGSMPRRDGMERKDLLRANVKIFKCQGAALEKYAKKSVKVIVVGNPANTNCLTAAKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTSDDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGDFITTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMG

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue238

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JQ735081
EMBL· GenBank· DDBJ
AFJ54470.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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