A0A0D2Y8Z1 · A0A0D2Y8Z1_FUSOF
- Protein5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
- Gene28954061
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids766 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
Cofactor
Note: Binds 2 Zn2+ ions per subunit.
Pathway
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 19 | 5-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 120 | 5-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 440-442 | L-homocysteine (UniProtKB | ChEBI) | |||
Binding site | 440-442 | L-methionine (UniProtKB | ChEBI) | |||
Binding site | 493 | L-methionine (UniProtKB | ChEBI) | |||
Binding site | 524-525 | 5-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 570 | 5-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 608 | L-homocysteine (UniProtKB | ChEBI) | |||
Binding site | 608 | L-methionine (UniProtKB | ChEBI) | |||
Binding site | 651 | Zn2+ 1 (UniProtKB | ChEBI); catalytic | |||
Binding site | 653 | Zn2+ 1 (UniProtKB | ChEBI); catalytic | |||
Binding site | 662 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 675 | Zn2+ 1 (UniProtKB | ChEBI); catalytic | |||
Active site | 704 | Proton donor | |||
Binding site | 736 | Zn2+ 1 (UniProtKB | ChEBI); catalytic | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity | |
Molecular Function | zinc ion binding | |
Biological Process | L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine | |
Biological Process | methylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Nectriaceae > Fusarium > Fusarium oxysporum species complex
Accessions
- Primary accessionA0A0D2Y8Z1
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 4-317 | Cobalamin-independent methionine synthase MetE N-terminal | |||
Region | 385-420 | Disordered | |||
Compositional bias | 389-419 | Basic and acidic residues | |||
Domain | 435-758 | Cobalamin-independent methionine synthase MetE C-terminal/archaeal | |||
Sequence similarities
Belongs to the vitamin-B12 independent methionine synthase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length766
- Mass (Da)86,552
- Last updated2015-04-29 v1
- MD5 ChecksumE891FDFD19C55C2B02DF888F2F6C5D40
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 389-419 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AFQF01003011 EMBL· GenBank· DDBJ | EGU77267.1 EMBL· GenBank· DDBJ | Genomic DNA |