A0A0D2XU09 · A0A0D2XU09_FUSOF

Function

function

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD per monomer.
FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per monomer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site91-96FMN (UniProtKB | ChEBI)
Binding site142-145FMN (UniProtKB | ChEBI)
Binding site183-192FMN (UniProtKB | ChEBI)
Binding site218FMN (UniProtKB | ChEBI)
Binding site311NADP+ (UniProtKB | ChEBI)
Binding site467-470FAD (UniProtKB | ChEBI)
Binding site485-487FAD (UniProtKB | ChEBI)
Binding site502-505FAD (UniProtKB | ChEBI)
Binding site564NADP+ (UniProtKB | ChEBI)
Binding site626-627NADP+ (UniProtKB | ChEBI)
Binding site632-636NADP+ (UniProtKB | ChEBI)
Binding site668NADP+ (UniProtKB | ChEBI)
Binding site706FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum membrane
Cellular Componentmitochondrial outer membrane
Cellular Componentplasma membrane
Molecular Functionflavin adenine dinucleotide binding
Molecular FunctionFMN binding
Molecular FunctionNADP binding
Molecular FunctionNADPH-hemoprotein reductase activity
Biological Processergosterol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADPH--cytochrome P450 reductase
  • EC number
  • Short names
    CPR
    ; P450R

Gene names

    • Name
      28949150
    • Synonyms
      cprA

Organism names

Accessions

  • Primary accession
    A0A0D2XU09

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass membrane protein
Mitochondrion outer membrane
; Single-pass membrane protein
Cell membrane
; Single-pass membrane protein

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the NADPH--cytochrome P450 reductase family.
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
In the N-terminal section; belongs to the flavodoxin family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    706
  • Mass (Da)
    78,181
  • Last updated
    2015-04-29 v1
  • MD5 Checksum
    9A3C8252280EAD7F770CD605A4F34396
MADIDIMTNESILDEALLTTESPVIDSTDLIVLLSLLLGAIVYISNGKLRNPFFPKPTTSAETTASKEDSLRSISHICNTTGKNCIIFYGSQTGTAENYAQKLAREASSRYGLDPMVADLEEYDYNDFSELSEQVVLMFVLATYGEGEPTDNAQDFYTYITGGEDGDQPDADLQNVKYVAFGLGNSTYEHYNAMVRRVSKALDQLGAKNLASIGEADDAAGTTEEDFLAWKQDMWPKLVQEFGLQERDVAYESTFGVLERDDLSASSPGVFLGEANADHLDTSSGNRQFSNTNPYIAKITESREVFTSEDRNCIHMEIDLGDSGLSYETGDHIAIWPTNSEDQVAQLLNILGLTEKKDTVISIVSREATAKSPVPTPTTYAAALRYYLEITGPVSREFINVIAAFAPTEIAKVEATKLGSDKVYFHEKISQKCLSLAQVLSMLSGGQPWPKLPFSAIVEGLSKLQPRYYSISSSSLVQPSLVSITAAVESAEIQGRPDVFKGVATNYLLSLKQAQNQESQSQEYQLDGPREKYVGFKAPVHLRKSNFKLPKDSSRPVIMIGPGTGVAPFRGFVQERAALKKQGKKVGKSLLFFGCRRRDEDYLYESEWEEHKNTLGDSFDIHTAFSREAKQKVYVQHLIKSHANDVIDMIDNGAIVYVCGDAKHMARDVNSTLISIWAEQRNISVESATEKVKGLRDTARYQEDIW

Keywords

Genome annotation databases

Similar Proteins

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