A0A0D2XQY5 · A0A0D2XQY5_FUSOF

Function

function

Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site25Schiff-base intermediate with DNA; for 5'-deoxyribose-5-phosphate lyase activity

GO annotations

AspectTerm
Cellular Componentchromosome, subtelomeric region
Cellular Componentchromosome, telomeric repeat region
Cellular ComponentKu70:Ku80 complex
Cellular Componentpericentric heterochromatin
Cellular Componentsite of double-strand break
Molecular FunctionATP binding
Molecular Functiondamaged DNA binding
Molecular Functiondouble-stranded DNA binding
Molecular Functiondouble-stranded DNA helicase activity
Molecular Functionforked DNA-dependent helicase activity
Molecular Functionfour-way junction helicase activity
Molecular Functionhydrolase activity
Molecular Functionsingle-stranded 3'-5' DNA helicase activity
Molecular Functiontelomeric DNA binding
Biological ProcessDNA recombination
Biological Processdouble-strand break repair via nonhomologous end joining
Biological Processstalled replication fork localization to nuclear periphery
Biological Processtelomere maintenance

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent DNA helicase II subunit 1
  • EC number
  • Alternative names
    • ATP-dependent DNA helicase II subunit Ku70

Gene names

    • Name
      28948284

Organism names

Accessions

  • Primary accession
    A0A0D2XQY5

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for compositional bias, region.

Type
IDPosition(s)Description
Compositional bias1-10Basic and acidic residues
Region1-25Disordered
Compositional bias11-21Acidic residues
Region38-57Disordered
Region548-591Disordered

Sequence similarities

Belongs to the ku70 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    644
  • Mass (Da)
    72,165
  • Last updated
    2015-04-29 v1
  • MD5 Checksum
    98BF1980A3DC509B3381447837A4FDD5
MADKQNWRKEDEDEEEQELDENNYKAQKDAILLAIDVSKSMLEPPPPSDSKKADRDSPVQAALKCAYHLMEQRIISNPKDMMGILLFGTKKSKFQDSVDGRSGLGYPHCYLFTDLDVPAAEDVKVLKALVEDGEDEDEVLTPSDEPVSMSNVLFCANQIFTTKAANFGSRRLFIVTDNDNPHASDKQAKSAAAVRAKDLYDLGILIDLFPITRGDEKFDLSKFYDDIIYRDPVGEANMTEVRTSKSGDGLTLLKSLISNVNSKQTAKRALFSNLPFEIAPGLRISVKGYNIVHRQTPARTCYIWLDGEKPQIATGETTRIAEDSARTVEKAEIKKAYKFGGEYVYFSPDEQKSLKDFGSPIIRIIGFKPRSLLPVWASTKKSTFIFPSEEDYVGSTRVFTALWQKLLKDDKMGVAWCITRANAQPMLAAIIPSRERSDADSGTPYLPAGLWIYPLPFQDDLRNINPPSEVLRSSGELTTQMRTIIQQLQLPKAMYDPLKYPNPALQWHYRILQALALEEEVPEKADDATEPKYKAISKRAGGYLEEWSESLEEESGKVANKKSTKRETDDEDMDRPVKKSRGSSEKATGSSFSMAQLKAAIEGGTIQKMTVVQLKDILATKGMSTAGRKVELIERIEQWIEESS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-10Basic and acidic residues
Compositional bias11-21Acidic residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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