A0A0D2XNB5 · A0A0D2XNB5_FUSOF
- ProteinDelta-aminolevulinic acid dehydratase
- Gene28947421
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids386 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
Catalytic activity
- 2 5-aminolevulinate = porphobilinogen + 2 H2O + H+
Pathway
Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 179 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 181 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 189 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Active site | 256 | Schiff-base intermediate with substrate | |||
Binding site | 266 | 5-aminolevulinate 1 (UniProtKB | ChEBI) | |||
Binding site | 278 | 5-aminolevulinate 1 (UniProtKB | ChEBI) | |||
Active site | 309 | Schiff-base intermediate with substrate | |||
Binding site | 336 | 5-aminolevulinate 2 (UniProtKB | ChEBI) | |||
Binding site | 375 | 5-aminolevulinate 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | porphobilinogen synthase activity | |
Molecular Function | zinc ion binding | |
Biological Process | protoporphyrinogen IX biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDelta-aminolevulinic acid dehydratase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Nectriaceae > Fusarium > Fusarium oxysporum species complex
Accessions
- Primary accessionA0A0D2XNB5
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Proteomic databases
Interaction
Structure
Sequence
- Sequence statusComplete
- Length386
- Mass (Da)41,731
- Last updated2015-04-29 v1
- Checksum0F6BE267758D6D40
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AFQF01000699 EMBL· GenBank· DDBJ | EGU87199.1 EMBL· GenBank· DDBJ | Genomic DNA |