A0A0D2XNB5 · A0A0D2XNB5_FUSOF

Function

function

Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.

Catalytic activity

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.

Features

Showing features for binding site, active site.

138650100150200250300350
Type
IDPosition(s)Description
Binding site179Zn2+ (UniProtKB | ChEBI); catalytic
Binding site181Zn2+ (UniProtKB | ChEBI); catalytic
Binding site189Zn2+ (UniProtKB | ChEBI); catalytic
Active site256Schiff-base intermediate with substrate
Binding site2665-aminolevulinate 1 (UniProtKB | ChEBI)
Binding site2785-aminolevulinate 1 (UniProtKB | ChEBI)
Active site309Schiff-base intermediate with substrate
Binding site3365-aminolevulinate 2 (UniProtKB | ChEBI)
Binding site3755-aminolevulinate 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionporphobilinogen synthase activity
Molecular Functionzinc ion binding
Biological Processprotoporphyrinogen IX biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Delta-aminolevulinic acid dehydratase
  • EC number

Gene names

    • Name
      28947421
    • ORF names
      FOXB_02278

Organism names

Accessions

  • Primary accession
    A0A0D2XNB5
  • Secondary accessions
    • F9F7A3

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Proteomic databases

Interaction

Subunit

Homooctamer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region14-34Disordered

Sequence similarities

Belongs to the ALAD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    386
  • Mass (Da)
    41,731
  • Last updated
    2015-04-29 v1
  • Checksum
    0F6BE267758D6D40
MSFSSLVQDLSLRDSNGARRPQIPGPRSSVSTLDDRASHVSRAMSYTSTAATSVSISGDISSQLHGGYFHPLARSWQAERQLTKSMLIYPLFVTDGEGDMILVPSLPGQHQLSCDKLIPFLEPLVHKGLRSVMLFGVPMQTGTKDALGTAADDPEGPVIKAIQIIRRRFPQLFICCDVCLCEYTSHGHCGILRDDGSLNNQLSVDRISDVAIAYAKAGAHCVAPSDMNDGRIRAIKLKLIEEGIAHKTVLMSYSAKFSGCLYGPFRDAAGSAPSFGDRKCYQLPPGGRGLARRAIVRDINEGADIIMVKPASQYLDIISDAKDLGKDLPVAAYQVSGEYAMIHAGAKAGVFDLKAMAFESTEGILRAGATIVVSYFTPDFLDWLEN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AFQF01000699
EMBL· GenBank· DDBJ
EGU87199.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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