A0A0D2XJU6 · A0A0D2XJU6_FUSOF

Function

function

Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromosome, telomeric region
Cellular ComponentCMG complex
Cellular Componentcytoplasm
Cellular ComponentMCM complex
Cellular Componentnuclear pre-replicative complex
Cellular Componentreplication fork protection complex
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionchromatin binding
Molecular FunctionDNA replication origin binding
Molecular FunctionMCM complex binding
Molecular Functionsingle-stranded DNA helicase activity
Biological ProcessDNA strand elongation involved in DNA replication
Biological ProcessDNA unwinding involved in DNA replication
Biological Processdouble-strand break repair via break-induced replication
Biological Processmitotic DNA replication initiation
Biological Processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
Biological Processpremeiotic DNA replication
Biological Processsilent mating-type cassette heterochromatin formation
Biological Processsubtelomeric heterochromatin formation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA replication licensing factor MCM3
  • EC number

Gene names

    • Name
      28946272

Organism names

Accessions

  • Primary accession
    A0A0D2XJU6

Proteomes

Organism-specific databases

Subcellular Location

Interaction

Subunit

Component of the MCM2-7 complex.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the MCM family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    879
  • Mass (Da)
    97,367
  • Last updated
    2015-04-29 v1
  • Checksum
    26D53224FCB07F3F
MDSFMLQDEGVRDRIRQAEEFLDPNDPQVRSYRSDIILMLQKNQRRLTVNLDHVRNHSPDLAQGLLQQPFDFTLAFDQALKNIVQTIPQARPDQTAKDTIYYCAWAGSFGLNACNPRTLSSHLLNYMVSIEGIVTRCSLIRPKVVKSVHYNEKKDMFHFREYQDQTMTNGVTTSSVYPREDDDGNPLITEYGFCTYRDHQTISIQEMPERAPAGQLPRGVDAILDDDLVDSVKPGDRVQLVGIYRTLGNRNTNHNSALFKTMILTNNVVLLSSKSGGGVATATITDTDIRNINKVAKKKNLLELLSQSLAPSIYGHDYVKKAILLMLLGGMEKNLENGTHLRGDINILMVGDPSTAKSQLLRFVLNTAPLAIATTGRGSSGVGLTAAVTSDKETGERRLEAGAMVMADRGVVCIDEFDKMSDVDRVAIHEVMEQQTVTIAKAGIHTSLNARCSVVAAANPIFGQYDPHKDPHKNIALPDSLLSRFDLLFVVTDDIEDTRDRHVSEHVLRMHRYRQPGTEEGAPVREQGGQSLGVSASNQTESQGPTEVYQKYDAMLHSGVTITSGRGSNKKPEILSIPFMKKYIQYAKTRIKPILTQEASDRIADIYVGLRNDEMEGNQRRTSPLTVRTLETIIRLATAHAKSRLSNRVEERDAAAAEGILRFALFKEVVEESRKKRRKTQTVDFASSSDESSSDDEDDDGDIANATQSNRSTSRATRNSSRLQARETSDTARSSREPDVPEDDSQSTLRRSSRRTQDQSQSQASFASSIPASQLPSSNQLESQDGDEDLASGAAALAIDDTPISSERLTTFRTALGQLLNTNLFEDDAAELDAVVEAVNKKIGNRRDAFDKGEATKALQKMGEANQIMFTEGDLVYKI

Keywords

Genome annotation databases

Similar Proteins

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