A0A0D2UGU1 · A0A0D2UGU1_GOSRA

Function

function

Catalytic subunit of pyrophosphate--fructose 6-phosphate 1-phosphotransferase. Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Allosterically activated by fructose 2,6-bisphosphate.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.

Features

Showing features for binding site, site, active site.

TypeIDPosition(s)Description
Binding site25diphosphate (UniProtKB | ChEBI)
Binding site119Mg2+ (UniProtKB | ChEBI); catalytic
Site120Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Site146Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Binding site147-149substrate
Active site149Proton acceptor
Binding site186-187substrate; ligand shared between dimeric partners
Binding site194-196substrate
Binding site255substrate
Binding site360-363substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function6-phosphofructokinase activity
Molecular FunctionATP binding
Molecular Functiondiphosphate-fructose-6-phosphate 1-phosphotransferase activity
Molecular Functionmetal ion binding
Biological Processfructose 6-phosphate metabolic process
Biological Processphotosynthesis
Biological Processresponse to glucose

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta
  • EC number
  • Short names
    PFP
  • Alternative names
    • 6-phosphofructokinase, pyrophosphate dependent
    • PPi-PFK
    • Pyrophosphate-dependent 6-phosphofructose-1-kinase

Gene names

    • Name
      PFP-BETA
    • ORF names
      B456_010G184300

Organism names

Accessions

  • Primary accession
    A0A0D2UGU1

Proteomes

Genome annotation databases

Subcellular Location

Keywords

Interaction

Subunit

Tetramer of two alpha (regulatory) and two beta (catalytic) chains.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain17-330Phosphofructokinase

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    487
  • Mass (Da)
    53,385
  • Last updated
    2015-04-29 v1
  • Checksum
    58524835E2F24EB4
MLVPNGVDNIGSDQKLKIGVVLSGGQAPGGHNVISGIFDYLQERAPGSTLYGFKGGPAGIMKGKYVELTADYIYPYRNQGGFDMICSGRDKIETPEQFKQAEETAAKLDLDGLVVIGGDDSNTNACLLAENFRSKNLKTRVIGCPKTIDGDLKCKEVPTSFGFDTACKIYAEMIGNVMIDARSTGKYYHFVRLMGRAASHITLECALQTHPNITIIGEEVAAKKLTLKNVTDYMVDVICKRAELGYNYGVILIPEGLIDFIPEVQQLIAELNEILAHDVVDENGLWKKKLTDQSLKLFEFLPQAIQEQLMLERDPHGNVQVAKIETEKMLIQMVETELEKRKQEGSYKANFKGQSHFFGYEGRCGLPTNFDASYCYALGYGAGALLHSGKTGLISSVGNLCAPVEEWTVGGTALTSMMDVERRHGKFKPVIKKAMVELDGAPFKKFASLREEWASKNCYISPGPIQFVGPASNAVNHTLLLELGAQA

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0D2UEP9A0A0D2UEP9_GOSRAPFP-BETA566
A0A0D2UEQ6A0A0D2UEQ6_GOSRAPFP-BETA558
A0A0D2SV36A0A0D2SV36_GOSRAPFP-BETA556
A0A0D2R9T6A0A0D2R9T6_GOSRAPFP-BETA460
A0A0D2VBZ3A0A0D2VBZ3_GOSRAB456_010G184300480
A0A0D2VBZ8A0A0D2VBZ8_GOSRAPFP-BETA502

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM001749
EMBL· GenBank· DDBJ
KJB67271.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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