A0A0D2FAN2 · A0A0D2FAN2_CLAB1

Function

function

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site15phosphate (UniProtKB | ChEBI)
Binding site63-64phosphate (UniProtKB | ChEBI)
Binding site96-97phosphate (UniProtKB | ChEBI)
Site180Important for substrate specificity
Binding site198substrate
Binding site199phosphate (UniProtKB | ChEBI)
Binding site222-224substrate
Site235Important for substrate specificity

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular Functionhydrolase activity
Molecular FunctionS-methyl-5-thioadenosine phosphorylase activity
Biological ProcessL-methionine salvage from methylthioadenosine
Biological Processpurine ribonucleoside salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    S-methyl-5'-thioadenosine phosphorylase
  • EC number
  • Alternative names
    • 5'-methylthioadenosine phosphorylase
      (MTA phosphorylase
      ; MTAP
      ; MTAPase
      )

Gene names

    • ORF names
      Z519_00839

Organism names

Accessions

  • Primary accession
    A0A0D2FAN2

Proteomes

Subcellular Location

Cytoplasm
Nucleus

Keywords

Interaction

Subunit

Homotrimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-257Nucleoside phosphorylase
Domain339-581Phospholipase/carboxylesterase/thioesterase

Sequence similarities

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    660
  • Mass (Da)
    73,801
  • Last updated
    2015-04-29 v1
  • Checksum
    6AB8B3DA808EA7D7
MSFTGPVHIAVIGGTGLEHLPDFRKAAILTVDTPWGPPSSPITILEHPSPTTGHPIPIAFLARHGPHHALAPHEVPSRANIAALRHIGVRCIIAFSAAGSLAEEVKPRDFVVPDQVIDRTKGVRPWTFFEEGVVCHVPFADPFDAKVGDVVRQCGHSLEGDGVVLHDSGTLIVMEGPQFSTRAESNLYRTWGGTVINMSTLPEAKLAAEAEIAYQVILMSTDYDCWHDVHGDVSVEMVMGHMRANAVNARRFIAAVLDELSKEEHDDLVRATHLAGARKFGVSTYPEGRGEKALEKLRWLFEGVLKWTVGHGSSPAILSATVEWCRRSSQNRTWSSPRPGHSHTHTVIFLHGRDSSAHEFANELFDSEASPELADSDRTLPALLPTVRWVFPQAPMLWSARLRSEMPQWFDMWTTEDPREAEHAALQRPGLRRVVSQILHTLDSEERLVPTTRIFVCGISQGCAAAIAALISRDGNAWRRMAGLAGLAGLSSWMPRQVEVDEKEQGAHYHRPADCEAWRTLPVMLQHCADDEVITVSHGRHLRDELTNTWSHQGVEWSEYEDGRHWLNEPRGVDDLVGFLRRCMAKERLPQHQQPENGRTWTRIIDDQQPQNDGTTERIEMINMNDTGAVVLQTRTRQRRSKKIIQDNEQLAIKMARITP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KN846980
EMBL· GenBank· DDBJ
KIW99176.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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