A0A0D2DEP7 · A0A0D2DEP7_9EURO
- ProteinCarbamoyl phosphate synthase arginine-specific small chain
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids471 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Small subunit of the arginine-specific carbamoyl phosphate synthase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, carbonate, and phosphate donated by ATP, the first step of the arginine biosynthetic pathway. The small subunit (glutamine amidotransferase) binds and cleaves glutamine to supply the large subunit with the substrate ammonia.
Catalytic activity
- 2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H+ + L-glutamate + phosphate
- H2O + L-glutamine = L-glutamate + NH4+
Pathway
Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 307 | Nucleophile | ||||
Sequence: C | ||||||
Active site | 391 | |||||
Sequence: H | ||||||
Active site | 393 | |||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | carbamoyl-phosphate synthase complex | |
Cellular Component | mitochondrial matrix | |
Molecular Function | ATP binding | |
Molecular Function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | arginine biosynthetic process | |
Biological Process | glutamine metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCarbamoyl phosphate synthase arginine-specific small chain
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Chaetothyriomycetidae > Chaetothyriales > Herpotrichiellaceae > Fonsecaea
Accessions
- Primary accessionA0A0D2DEP7
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 51-190 | Carbamoyl-phosphate synthase small subunit N-terminal | ||||
Sequence: ERATFTIRNGPIFDGVSFGARSNVSGEAVFTTSLVGYPESLTDPSYRGQILVFTQPLIGNYGVPSNARDEHGLLKYFESPNIQAVGVVVADVAEKYSHWTAVESLSEWCAREGVPAISGVDTRAIVTFLREQGSSLARIT |
Sequence similarities
Belongs to the CarA family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length471
- Mass (Da)51,343
- Last updated2015-04-29 v1
- Checksum3999FB0B4AEFDB99
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KN846975 EMBL· GenBank· DDBJ | KIW76151.1 EMBL· GenBank· DDBJ | Genomic DNA |