A0A0D2DAI0 · A0A0D2DAI0_9EURO
- ProteinATP-dependent DNA helicase CHL1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids835 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G2/M (By similarity).
May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity).
Has a specific role in chromosome segregation during meiosis II
May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity).
Has a specific role in chromosome segregation during meiosis II
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
- Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction. This creates two antiparallel DNA single strands (ssDNA). The leading ssDNA polymer is the template for DNA polymerase III holoenzyme which synthesizes a continuous strand.
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA helicase activity | |
Molecular Function | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | |
Biological Process | establishment of sister chromatid cohesion | |
Biological Process | nucleobase-containing compound metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent DNA helicase CHL1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Chaetothyriomycetidae > Chaetothyriales > Herpotrichiellaceae > Fonsecaea
Accessions
- Primary accessionA0A0D2DAI0
Proteomes
Organism-specific databases
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 4-414 | Helicase ATP-binding | ||||
Sequence: TQANFCHPYQPYSIQLDFMRELYRCIEERKVGIFESPTGTGKSLSLICGALTWLRDHEQRALQGLTDGGEPLDWLLEAEKTAQRRELLLEREELELRLSRIRKEEASRRQRQHDAKTSKKPRTKIPNDEGNAPDEDEFTLEDYDSEREETSIANYSTAGLSSSTQALLDKLQGPMRTNVEEQEEKDRLKIIFCSRTHSQLTQFVNELRRVKPPPSLSLEAADFTHKPSLEERVKHLALASRKNLCINSKVAGLSSAFAINEQCLELQKPATPKDKKCPYIPARDDKSKVEDFRDRVVAEVRDIEDTSRLGREMQLCPYYASRAAITMSEVLTLPYPLLLQRSAREALGVSVKNNVVIIDEAHNLMDAIADTFSISLRLSQLEEGARQVTAYAGRFKNRLKGKNRVYVMQVI | ||||||
Region | 108-153 | Disordered | ||||
Sequence: EASRRQRQHDAKTSKKPRTKIPNDEGNAPDEDEFTLEDYDSEREET |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length835
- Mass (Da)94,774
- Last updated2015-04-29 v1
- Checksum71F0FF0B16E42EC2
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KN846976 EMBL· GenBank· DDBJ | KIW74576.1 EMBL· GenBank· DDBJ | Genomic DNA |