A0A0D2D4P4 · A0A0D2D4P4_9EURO

  • Protein
    NADPH-dependent diflavin oxidoreductase 1
  • Gene
    TAH18
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H2O2-induced cell death.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

FMN (UniProtKB | Rhea| CHEBI:58210 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site19-24FMN (UniProtKB | ChEBI)
Binding site66-69FMN (UniProtKB | ChEBI)
Binding site104-113FMN (UniProtKB | ChEBI)
Binding site139FMN (UniProtKB | ChEBI)
Binding site369FAD (UniProtKB | ChEBI)
Binding site399-402FAD (UniProtKB | ChEBI)
Binding site438-441FAD (UniProtKB | ChEBI)
Binding site481NADP+ (UniProtKB | ChEBI)
Binding site543-544NADP+ (UniProtKB | ChEBI)
Binding site651FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmitochondrion
Molecular Functionflavin adenine dinucleotide binding
Molecular FunctionFMN binding
Molecular FunctionNADP binding
Molecular FunctionNADPH-hemoprotein reductase activity
Biological Processiron-sulfur cluster assembly

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADPH-dependent diflavin oxidoreductase 1
  • EC number
  • Alternative names
    • NADPH-dependent FMN and FAD-containing oxidoreductase

Gene names

    • Name
      TAH18
    • ORF names
      PV05_05892

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CBS 118157
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Chaetothyriomycetidae > Chaetothyriales > Herpotrichiellaceae > Exophiala

Accessions

  • Primary accession
    A0A0D2D4P4

Proteomes

Subcellular Location

Cytoplasm
Mitochondrion
Note: Relocalizes to mitochondria after H2O2 exposure.

Keywords

Interaction

Subunit

Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain13-157Flavodoxin-like
Region188-219Disordered
Domain216-466FAD-binding FR-type
Region601-628Disordered

Sequence similarities

Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
In the N-terminal section; belongs to the flavodoxin family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    652
  • Mass (Da)
    73,485
  • Last updated
    2015-04-29 v1
  • Checksum
    3D26DAE5AEE2F114
MMKNNGFDPTRSVIVLYGTETGTSQDFAEEIGRCLERLRFNTDVAGLESVNYNDLRVYTLAVFVIATTGQGDFPENARRFWTSILRKRLSSTTLLGIEYALVGLGDSSYPKFNFAARKLEKRLGQLGATSIIESCEADEQGDEGTDGAVLAWLEQFRQTLLTRFPLGDGQQPIPNDVLLPSKWRLTRRPTSAEDAGAHEASNGTELDPPASESFSSESFESTLMANDRVTPTDHFQDVRFMTLKILHTIRYSPGDAIAILPQNMPTDVTFLIERMNWQDVADIPISLISTRRPSTSNSAHLATSPVFGRKDLTLRTLLTEYLDINAIPRRSFFGAIANYTTDNMHKERLLEFTDPQYLDEYYDYATRPRRSILEILQEFDTVHLPWEEVTNIFPPMRPRQFSIASGGKSKHLDDGSTVFELLVAIVKYRTVIKRIREGVCTRYLAQLPVGTKLQVSLKTEGRFAKASDMAGESHLLIGAGTGIAPLRALIHEKVAQYPVAGKTALIFGCRSAKADYFFGDEWATLQSVPGSDEARLDVITAFSRDQKNKIYIQDRIRERSDLVWEYLRQRHATIIVCGSSGQMPKAVRQALVDALVQQAQKRHAEEKPNGSTELMNSDEEDEAEERIECQEDAEKYLARLEKEGRYKQETWS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KN847319
EMBL· GenBank· DDBJ
KIW57327.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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