A0A0D1JMD6 · A0A0D1JMD6_STAAU

Function

function

Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

Activity regulation

Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.

Pathway

Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site12-14substrate
Binding site41-45substrate
Binding site142substrate
Binding site186ATP (UniProtKB | ChEBI)
Binding site222-227ATP (UniProtKB | ChEBI)
Binding site248K+ (UniProtKB | ChEBI)
Binding site250K+ (UniProtKB | ChEBI)
Binding site253-254ATP (UniProtKB | ChEBI)
Active site254Proton acceptor
Binding site254substrate
Binding site279ATP (UniProtKB | ChEBI)
Binding site285K+ (UniProtKB | ChEBI)
Binding site288K+ (UniProtKB | ChEBI)
Binding site290K+ (UniProtKB | ChEBI)
Binding site294K+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionribokinase activity
Biological ProcessD-ribose catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribokinase
  • EC number
  • Short names
    RK

Gene names

    • Name
      rbsK
    • ORF names
      DQV00_09220
      , G0Z31_11610
      , G6W84_12145
      , G6Y24_11330
      , GQX52_06140
      , M1K003_0499
      , QU38_14445
      , SAMEA70153168_00742

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • SA-120
    • M1K003
    • Pt061.1
    • pt061.1
    • UP89
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus

Accessions

  • Primary accession
    A0A0D1JMD6
  • Secondary accessions
    • A0A3M8ZCK7

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-296Carbohydrate kinase PfkB

Sequence similarities

Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    304
  • Mass (Da)
    32,451
  • Last updated
    2015-04-29 v1
  • Checksum
    0DDE818D5B466F32
MTNKVVILGSTNVDQFLTVERYAQPGETLHVEEAQKAFGGGKGANQAIATARMQADTTFITKIGTDGVADFILEDFKAAHIDTSYIIKTTEAKTGQAFITVNAEGQNTIYVYGGANMTMTPEDVINAKDAIINADFVVAQLEVPIPAIISAFEIAKAHGVTTVLNPAPAKALPNELLSLIDIIVPNETEAELLSGIKVTNEQSMKDNANYFLSLGIKTVLITLGKQGTYFATKNQSQHIEAYKVNAIDTTAAGDTFIGAFVSRLNKSQDNLADAIDFGNKASSLTVQKHGAQASIPLLEEVNQV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAIIGN010000002
EMBL· GenBank· DDBJ
CAC8221480.1
EMBL· GenBank· DDBJ
Genomic DNA
BDVT01000002
EMBL· GenBank· DDBJ
GBV19527.1
EMBL· GenBank· DDBJ
Genomic DNA
JXIG01000630
EMBL· GenBank· DDBJ
KIT95116.1
EMBL· GenBank· DDBJ
Genomic DNA
JAAJIY010000046
EMBL· GenBank· DDBJ
NGK22136.1
EMBL· GenBank· DDBJ
Genomic DNA
JAALWO010000038
EMBL· GenBank· DDBJ
NGV47842.1
EMBL· GenBank· DDBJ
Genomic DNA
JAALTR010000284
EMBL· GenBank· DDBJ
NGW68065.1
EMBL· GenBank· DDBJ
Genomic DNA
JAANDN010000059
EMBL· GenBank· DDBJ
NUY68224.1
EMBL· GenBank· DDBJ
Genomic DNA
QNXM01000003
EMBL· GenBank· DDBJ
TXL49849.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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