A0A0D1JEX8 · A0A0D1JEX8_STAAU

  • Protein
    Hypoxanthine phosphoribosyltransferase
  • Gene
    hpt
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Purine metabolism; GMP biosynthesis via salvage pathway; GMP from guanine: step 1/1.
Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionguanine phosphoribosyltransferase activity
Molecular Functionhypoxanthine phosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Molecular Functionnucleotide binding
Biological ProcessGMP salvage
Biological Processguanine salvage
Biological Processhypoxanthine metabolic process
Biological ProcessIMP salvage
Biological Processpurine ribonucleoside salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hypoxanthine phosphoribosyltransferase
  • EC number

Gene names

    • Name
      hpt
    • ORF names
      ACR74_13870
      , C0102_14795
      , CNH36_02750
      , CV021_07750
      , DQU50_08500
      , DQU51_09975
      , E1948_02515
      , E1948_11910
      , EP54_03210
      , EQ90_10875
      , G0Z31_11275
      , G6Y24_02395
      , GO793_07110
      , GO814_00850
      , GO942_14405
      , GQX37_08795
      , GQX52_04630
      , GZ111_005450
      , GZ164_11100
      , HH313_000486
      , LB359_05660
      , M1K003_2657
      , NCTC10702_00910
      , NCTC5664_00168
      , NCTC6133_00581
      , NCTC7878_00027
      , NCTC7972_01439
      , QU38_03195
      , SAMEA1029512_02570
      , SAMEA1029528_02639
      , SAMEA1029536_02619
      , SAMEA1466929_02511
      , SAMEA1531725_02529
      , SAMEA1531744_02406
      , SAMEA2078260_02592
      , SAMEA2078588_02560
      , SAMEA2080344_02596
      , SAMEA2081063_02601
      , SAMEA4008575_02724
      , SAMEA4552975_02566
      , SAMEA70146418_02794
      , SAMEA70153168_02540

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • CA15
    • M121
    • MRSA_S20
    • SA-120
    • M1K003
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus

Accessions

  • Primary accession
    A0A0D1JEX8
  • Secondary accessions
    • A0A1E8WRY1

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain14-160Phosphoribosyltransferase

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    179
  • Mass (Da)
    20,154
  • Last updated
    2015-04-29 v1
  • Checksum
    E7D35987B435EFB0
MHNDLKEVLLTEEDIQNICKELGAQLTKDYQGKPLVCVGILKGSAMFMSDLIKRIDTHLSIDFMDVSSYHGGTESTGEVQIIKDLGSSIENKDVLIIEDILETGTTLKSITELLQSRKVNSLEIVTLLDKPNRRKADIEAKYVGKKIPDEFVVGYGLDYRELYRNLPYIGTLKPEVYSN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP023391
EMBL· GenBank· DDBJ
ATC70609.1
EMBL· GenBank· DDBJ
Genomic DNA
CACTOE010000024
EMBL· GenBank· DDBJ
CAA4161901.1
EMBL· GenBank· DDBJ
Genomic DNA
CACTPI010000018
EMBL· GenBank· DDBJ
CAA4164543.1
EMBL· GenBank· DDBJ
Genomic DNA
CACTPG010000026
EMBL· GenBank· DDBJ
CAA4181131.1
EMBL· GenBank· DDBJ
Genomic DNA
CACTQT010000021
EMBL· GenBank· DDBJ
CAA4398073.1
EMBL· GenBank· DDBJ
Genomic DNA
CACTWD010000022
EMBL· GenBank· DDBJ
CAA4705011.1
EMBL· GenBank· DDBJ
Genomic DNA
CACUNS010000021
EMBL· GenBank· DDBJ
CAA6125074.1
EMBL· GenBank· DDBJ
Genomic DNA
CACURZ010000021
EMBL· GenBank· DDBJ
CAA6388868.1
EMBL· GenBank· DDBJ
Genomic DNA
CAIGXB010000016
EMBL· GenBank· DDBJ
CAC5810800.1
EMBL· GenBank· DDBJ
Genomic DNA
CAIHOM010000006
EMBL· GenBank· DDBJ
CAC7021351.1
EMBL· GenBank· DDBJ
Genomic DNA
CAIIGD010000017
EMBL· GenBank· DDBJ
CAC8237949.1
EMBL· GenBank· DDBJ
Genomic DNA
CAIIGN010000013
EMBL· GenBank· DDBJ
CAC8254364.1
EMBL· GenBank· DDBJ
Genomic DNA
BDVT01000019
EMBL· GenBank· DDBJ
GBV21636.1
EMBL· GenBank· DDBJ
Genomic DNA
JXIG01000616
EMBL· GenBank· DDBJ
KIT97959.1
EMBL· GenBank· DDBJ
Genomic DNA
LALJ01000028
EMBL· GenBank· DDBJ
KMR35846.1
EMBL· GenBank· DDBJ
Genomic DNA
LALQ01000010
EMBL· GenBank· DDBJ
KMR58041.1
EMBL· GenBank· DDBJ
Genomic DNA
LFVK01000014
EMBL· GenBank· DDBJ
KSA73269.1
EMBL· GenBank· DDBJ
Genomic DNA
JAIGOF010000019
EMBL· GenBank· DDBJ
MBX8595284.1
EMBL· GenBank· DDBJ
Genomic DNA
JAIUEN010000033
EMBL· GenBank· DDBJ
MCE3361847.1
EMBL· GenBank· DDBJ
Genomic DNA
WPRH01000431
EMBL· GenBank· DDBJ
MVI55616.1
EMBL· GenBank· DDBJ
Genomic DNA
WPTS01000008
EMBL· GenBank· DDBJ
MVK33695.1
EMBL· GenBank· DDBJ
Genomic DNA
WPXC01000035
EMBL· GenBank· DDBJ
MVM11855.1
EMBL· GenBank· DDBJ
Genomic DNA
JAAFMT010000021
EMBL· GenBank· DDBJ
NDR16905.1
EMBL· GenBank· DDBJ
Genomic DNA
JAAJIY010000043
EMBL· GenBank· DDBJ
NGK22074.1
EMBL· GenBank· DDBJ
Genomic DNA
JAALTR010000054
EMBL· GenBank· DDBJ
NGW66352.1
EMBL· GenBank· DDBJ
Genomic DNA
JAANEC010000085
EMBL· GenBank· DDBJ
NUY12615.1
EMBL· GenBank· DDBJ
Genomic DNA
JAANDN010000046
EMBL· GenBank· DDBJ
NUY67945.1
EMBL· GenBank· DDBJ
Genomic DNA
PGWZ01000364
EMBL· GenBank· DDBJ
PPJ74582.1
EMBL· GenBank· DDBJ
Genomic DNA
PKSU01000019
EMBL· GenBank· DDBJ
PZL77780.1
EMBL· GenBank· DDBJ
Genomic DNA
CP038850
EMBL· GenBank· DDBJ
QCT56360.1
EMBL· GenBank· DDBJ
Genomic DNA
CP053070
EMBL· GenBank· DDBJ
QJR06691.1
EMBL· GenBank· DDBJ
Genomic DNA
UAUX01000001
EMBL· GenBank· DDBJ
SPZ96498.1
EMBL· GenBank· DDBJ
Genomic DNA
UDJK01000015
EMBL· GenBank· DDBJ
SRC30970.1
EMBL· GenBank· DDBJ
Genomic DNA
UELG01000021
EMBL· GenBank· DDBJ
SRZ67693.1
EMBL· GenBank· DDBJ
Genomic DNA
UHAI01000002
EMBL· GenBank· DDBJ
SUK17907.1
EMBL· GenBank· DDBJ
Genomic DNA
UHAQ01000002
EMBL· GenBank· DDBJ
SUK31450.1
EMBL· GenBank· DDBJ
Genomic DNA
UHAP01000001
EMBL· GenBank· DDBJ
SUK33019.1
EMBL· GenBank· DDBJ
Genomic DNA
UHBY01000003
EMBL· GenBank· DDBJ
SUL32608.1
EMBL· GenBank· DDBJ
Genomic DNA
UIOA01000018
EMBL· GenBank· DDBJ
SVG15372.1
EMBL· GenBank· DDBJ
Genomic DNA
QNXH01000001
EMBL· GenBank· DDBJ
TXL37834.1
EMBL· GenBank· DDBJ
Genomic DNA
QNXF01000003
EMBL· GenBank· DDBJ
TXL39553.1
EMBL· GenBank· DDBJ
Genomic DNA
CP152420
EMBL· GenBank· DDBJ
XAJ31443.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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