A0A0D1JEX8 · A0A0D1JEX8_STAAU
- ProteinHypoxanthine phosphoribosyltransferase
- Genehpt
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids179 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi.
Catalytic activity
- GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphateThis reaction proceeds in the backward direction.
Cofactor
Pathway
Purine metabolism; GMP biosynthesis via salvage pathway; GMP from guanine: step 1/1.
Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | guanine phosphoribosyltransferase activity | |
Molecular Function | hypoxanthine phosphoribosyltransferase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | nucleotide binding | |
Biological Process | GMP salvage | |
Biological Process | guanine salvage | |
Biological Process | hypoxanthine metabolic process | |
Biological Process | IMP salvage | |
Biological Process | purine ribonucleoside salvage |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHypoxanthine phosphoribosyltransferase
- EC number
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus
Accessions
- Primary accessionA0A0D1JEX8
- Secondary accessions
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 14-160 | Phosphoribosyltransferase | ||||
Sequence: DIQNICKELGAQLTKDYQGKPLVCVGILKGSAMFMSDLIKRIDTHLSIDFMDVSSYHGGTESTGEVQIIKDLGSSIENKDVLIIEDILETGTTLKSITELLQSRKVNSLEIVTLLDKPNRRKADIEAKYVGKKIPDEFVVGYGLDYR |
Sequence similarities
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length179
- Mass (Da)20,154
- Last updated2015-04-29 v1
- ChecksumE7D35987B435EFB0
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP023391 EMBL· GenBank· DDBJ | ATC70609.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTOE010000024 EMBL· GenBank· DDBJ | CAA4161901.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTPI010000018 EMBL· GenBank· DDBJ | CAA4164543.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTPG010000026 EMBL· GenBank· DDBJ | CAA4181131.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTQT010000021 EMBL· GenBank· DDBJ | CAA4398073.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTWD010000022 EMBL· GenBank· DDBJ | CAA4705011.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACUNS010000021 EMBL· GenBank· DDBJ | CAA6125074.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACURZ010000021 EMBL· GenBank· DDBJ | CAA6388868.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAIGXB010000016 EMBL· GenBank· DDBJ | CAC5810800.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAIHOM010000006 EMBL· GenBank· DDBJ | CAC7021351.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAIIGD010000017 EMBL· GenBank· DDBJ | CAC8237949.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAIIGN010000013 EMBL· GenBank· DDBJ | CAC8254364.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BDVT01000019 EMBL· GenBank· DDBJ | GBV21636.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JXIG01000616 EMBL· GenBank· DDBJ | KIT97959.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LALJ01000028 EMBL· GenBank· DDBJ | KMR35846.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LALQ01000010 EMBL· GenBank· DDBJ | KMR58041.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LFVK01000014 EMBL· GenBank· DDBJ | KSA73269.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAIGOF010000019 EMBL· GenBank· DDBJ | MBX8595284.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAIUEN010000033 EMBL· GenBank· DDBJ | MCE3361847.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WPRH01000431 EMBL· GenBank· DDBJ | MVI55616.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WPTS01000008 EMBL· GenBank· DDBJ | MVK33695.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WPXC01000035 EMBL· GenBank· DDBJ | MVM11855.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAAFMT010000021 EMBL· GenBank· DDBJ | NDR16905.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAAJIY010000043 EMBL· GenBank· DDBJ | NGK22074.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAALTR010000054 EMBL· GenBank· DDBJ | NGW66352.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAANEC010000085 EMBL· GenBank· DDBJ | NUY12615.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAANDN010000046 EMBL· GenBank· DDBJ | NUY67945.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
PGWZ01000364 EMBL· GenBank· DDBJ | PPJ74582.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
PKSU01000019 EMBL· GenBank· DDBJ | PZL77780.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP038850 EMBL· GenBank· DDBJ | QCT56360.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP053070 EMBL· GenBank· DDBJ | QJR06691.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UAUX01000001 EMBL· GenBank· DDBJ | SPZ96498.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UDJK01000015 EMBL· GenBank· DDBJ | SRC30970.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UELG01000021 EMBL· GenBank· DDBJ | SRZ67693.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UHAI01000002 EMBL· GenBank· DDBJ | SUK17907.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UHAQ01000002 EMBL· GenBank· DDBJ | SUK31450.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UHAP01000001 EMBL· GenBank· DDBJ | SUK33019.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UHBY01000003 EMBL· GenBank· DDBJ | SUL32608.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UIOA01000018 EMBL· GenBank· DDBJ | SVG15372.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QNXH01000001 EMBL· GenBank· DDBJ | TXL37834.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QNXF01000003 EMBL· GenBank· DDBJ | TXL39553.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP152420 EMBL· GenBank· DDBJ | XAJ31443.1 EMBL· GenBank· DDBJ | Genomic DNA |