A0A0D1I054 · A0A0D1I054_STAAU
- ProteinL-lactate dehydrogenase
- Geneldh2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids319 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of lactate to pyruvate.
Catalytic activity
- (S)-lactate + NAD+ = pyruvate + NADH + H+
Pathway
Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 12-17 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GDGSVG | ||||||
Binding site | 16 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 37 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 42 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 68 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 82-83 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GA | ||||||
Binding site | 85 | substrate | ||||
Sequence: Q | ||||||
Binding site | 91 | substrate | ||||
Sequence: R | ||||||
Binding site | 98 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 104 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 121-123 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: AAN | ||||||
Binding site | 123-126 | substrate | ||||
Sequence: NPVD | ||||||
Binding site | 146 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 151-154 | substrate | ||||
Sequence: DSAR | ||||||
Active site | 178 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 231 | substrate | ||||
Sequence: T |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | L-lactate dehydrogenase activity | |
Biological Process | glycolytic process | |
Biological Process | lactate metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameL-lactate dehydrogenase
- EC number
- Short namesL-LDH
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus
Accessions
- Primary accessionA0A0D1I054
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 222 | Phosphotyrosine | ||||
Sequence: Y |
Keywords
- PTM
Interaction
Subunit
Homotetramer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 7-145 | Lactate/malate dehydrogenase N-terminal | ||||
Sequence: KVVLIGDGSVGSSYAFAMVTQGVADEFVIIDIAKDKVKADVQDLNHGTVHSPSPVDVKAGEYEDCKDADLVVITAGAPQKPGETRLQLVEKNTKIMKSIVKSVMDSGFDGYFLIAANPVDILTRFVKEYTGLPAERVIG | ||||||
Domain | 148-312 | Lactate/malate dehydrogenase C-terminal | ||||
Sequence: TVLDSARLQYLISQELGVAPSSVDASIIGEHGDTELAVWSQANVAGISVYDTLKEQTGSEAKAEEIYVNTRDAAYEIIQAKGSTYYGIALALMRISKAILNNENNVLNVSIQLDGQYGGHKGVYLGVPTLVNQHGAVKIYEMPLSAEEQALFDKSVKTLEDTFDS |
Sequence similarities
Belongs to the LDH/MDH superfamily. LDH family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length319
- Mass (Da)34,420
- Last updated2015-04-29 v1
- Checksum7779343BCA8006C4
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP023391 EMBL· GenBank· DDBJ | ATC72783.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTOE010000001 EMBL· GenBank· DDBJ | CAA4076018.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTPI010000003 EMBL· GenBank· DDBJ | CAA4102235.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTPG010000006 EMBL· GenBank· DDBJ | CAA4128086.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTQT010000005 EMBL· GenBank· DDBJ | CAA4370095.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTWD010000004 EMBL· GenBank· DDBJ | CAA4676995.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACUNS010000005 EMBL· GenBank· DDBJ | CAA6068200.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACURZ010000003 EMBL· GenBank· DDBJ | CAA6324179.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAIGXB010000007 EMBL· GenBank· DDBJ | CAC5801673.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAIHOM010000002 EMBL· GenBank· DDBJ | CAC7008290.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAIIGD010000001 EMBL· GenBank· DDBJ | CAC8189635.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAIIKR010000001 EMBL· GenBank· DDBJ | CAC8491846.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UAUZ02000001 EMBL· GenBank· DDBJ | CAD7352662.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CVOQ01000037 EMBL· GenBank· DDBJ | CRI19418.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JXIG01000630 EMBL· GenBank· DDBJ | KIT95424.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LALJ01000005 EMBL· GenBank· DDBJ | KMR37719.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LALQ01000001 EMBL· GenBank· DDBJ | KMR58566.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LFVK01000007 EMBL· GenBank· DDBJ | KSA76767.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LRQH01000101 EMBL· GenBank· DDBJ | KXA36562.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAIGOF010000011 EMBL· GenBank· DDBJ | MBX8594747.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAIUEN010000050 EMBL· GenBank· DDBJ | MCE3362138.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WPRH01000219 EMBL· GenBank· DDBJ | MVI54852.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WPTS01000027 EMBL· GenBank· DDBJ | MVK35324.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WPVZ01000461 EMBL· GenBank· DDBJ | MVL45471.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WPXC01000030 EMBL· GenBank· DDBJ | MVM11302.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAAFMT010000008 EMBL· GenBank· DDBJ | NDR16125.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAANEC010000024 EMBL· GenBank· DDBJ | NUY11354.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LNJK01000008 EMBL· GenBank· DDBJ | OWT14766.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
PGWZ01000541 EMBL· GenBank· DDBJ | PPJ70225.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
PKSU01000004 EMBL· GenBank· DDBJ | PZL80443.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP038850 EMBL· GenBank· DDBJ | QCT58366.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP053070 EMBL· GenBank· DDBJ | QJR08727.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RQSX01000165 EMBL· GenBank· DDBJ | RZH93163.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UAUX01000005 EMBL· GenBank· DDBJ | SPZ97443.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UDJK01000004 EMBL· GenBank· DDBJ | SRC24624.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UELG01000002 EMBL· GenBank· DDBJ | SRZ64593.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UHAI01000002 EMBL· GenBank· DDBJ | SUK18479.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UHAQ01000002 EMBL· GenBank· DDBJ | SUK42496.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UHAP01000001 EMBL· GenBank· DDBJ | SUK61630.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UIOA01000010 EMBL· GenBank· DDBJ | SVG10828.1 EMBL· GenBank· DDBJ | Genomic DNA |