A0A0D1HIF4 · A0A0D1HIF4_STAAU
- ProteinAspartate carbamoyltransferase
- GenepyrB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids293 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the condensation of carbamoyl phosphate and aspartate to form carbamoyl aspartate and inorganic phosphate, the committed step in the de novo pyrimidine nucleotide biosynthesis pathway.
Catalytic activity
- carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H+
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 50 | carbamoyl phosphate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 51 | carbamoyl phosphate (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 78 | L-aspartate (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 100 | carbamoyl phosphate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 127 | carbamoyl phosphate (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 130 | carbamoyl phosphate (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 160 | L-aspartate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 210 | L-aspartate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 253 | carbamoyl phosphate (UniProtKB | ChEBI) | ||||
Sequence: A | ||||||
Binding site | 254 | carbamoyl phosphate (UniProtKB | ChEBI) | ||||
Sequence: P |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | amino acid binding | |
Molecular Function | aspartate carbamoyltransferase activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | 'de novo' UMP biosynthetic process | |
Biological Process | amino acid metabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAspartate carbamoyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus
Accessions
- Primary accessionA0A0D1HIF4
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Heterododecamer (2C3:3R2) of six catalytic PyrB chains organized as two trimers (C3), and six regulatory PyrI chains organized as three dimers (R2).
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 3-140 | Aspartate/ornithine carbamoyltransferase carbamoyl-P binding | ||||
Sequence: HLLSMEHLSTDQIYKLIQKASQFKSGERQLPNFEGKYVANLFFENSTRTKCSFEMAELKLGLKTISFETSTSSVSKGESLYDTCKTLESIGCDLLVIRHPFNNYYEKLANINIPIANAGDGSGQHPTQSLLDLMTIYE | ||||||
Domain | 146-288 | Aspartate/ornithine carbamoyltransferase Asp/Orn-binding | ||||
Sequence: EGLNVLICGDIKNSRVARSNYHSLKALGANVMFNSPNAWIDDSLEAPYVNIDDVIETVDIVMLLRIQHERHGLAEETRFAADDYHQKHGLNEVRYNKLQEHAIVMHPAPVNRGVEIQSDLVEASKSRIFKQMENGVYLRMAVI |
Sequence similarities
Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length293
- Mass (Da)33,258
- Last updated2015-04-29 v1
- ChecksumC4FC67C795DAFE27
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP023391 EMBL· GenBank· DDBJ | ATC71293.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTPI010000001 EMBL· GenBank· DDBJ | CAA4077048.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTOE010000002 EMBL· GenBank· DDBJ | CAA4078559.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTPG010000022 EMBL· GenBank· DDBJ | CAA4177928.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTQT010000007 EMBL· GenBank· DDBJ | CAA4376303.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACTWD010000007 EMBL· GenBank· DDBJ | CAA4682903.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACUNS010000008 EMBL· GenBank· DDBJ | CAA6088083.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CACURZ010000008 EMBL· GenBank· DDBJ | CAA6361219.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAIGXB010000006 EMBL· GenBank· DDBJ | CAC5799120.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAIHOM010000001 EMBL· GenBank· DDBJ | CAC6989017.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAIIGD010000005 EMBL· GenBank· DDBJ | CAC8218551.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAIIGN010000006 EMBL· GenBank· DDBJ | CAC8240740.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAIIKR010000005 EMBL· GenBank· DDBJ | CAC8525434.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UAUZ02000002 EMBL· GenBank· DDBJ | CAD7352974.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BDVT01000001 EMBL· GenBank· DDBJ | GBV19079.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JXIG01000629 EMBL· GenBank· DDBJ | KIT95716.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LALJ01000013 EMBL· GenBank· DDBJ | KMR36667.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LALQ01000035 EMBL· GenBank· DDBJ | KMR56848.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LFVK01000002 EMBL· GenBank· DDBJ | KSA78140.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAIGOF010000005 EMBL· GenBank· DDBJ | MBX8594022.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAIUEN010000013 EMBL· GenBank· DDBJ | MCE3361268.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WPTS01000025 EMBL· GenBank· DDBJ | MVK34779.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WPVZ01000746 EMBL· GenBank· DDBJ | MVL46579.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WPXC01000013 EMBL· GenBank· DDBJ | MVM10466.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAAJIY010000040 EMBL· GenBank· DDBJ | NGK22023.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAALTR010000324 EMBL· GenBank· DDBJ | NGW68484.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAANEC010000071 EMBL· GenBank· DDBJ | NUY12314.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAANDN010000088 EMBL· GenBank· DDBJ | NUY68897.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LNJK01000002 EMBL· GenBank· DDBJ | OWT17831.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
PKSU01000002 EMBL· GenBank· DDBJ | PZL81271.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP038850 EMBL· GenBank· DDBJ | QCT56966.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP053070 EMBL· GenBank· DDBJ | QJR07305.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RQSX01000178 EMBL· GenBank· DDBJ | RZH92987.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UDJK01000008 EMBL· GenBank· DDBJ | SRC28418.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UELG01000008 EMBL· GenBank· DDBJ | SRZ66123.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UHAI01000002 EMBL· GenBank· DDBJ | SUK16280.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UHBY01000003 EMBL· GenBank· DDBJ | SUL34606.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UIOA01000008 EMBL· GenBank· DDBJ | SVG07994.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QNXH01000001 EMBL· GenBank· DDBJ | TXL38569.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QNXF01000002 EMBL· GenBank· DDBJ | TXL46624.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP152420 EMBL· GenBank· DDBJ | XAJ30860.1 EMBL· GenBank· DDBJ | Genomic DNA |