A0A0D1HIF4 · A0A0D1HIF4_STAAU

  • Protein
    Aspartate carbamoyltransferase
  • Gene
    pyrB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the condensation of carbamoyl phosphate and aspartate to form carbamoyl aspartate and inorganic phosphate, the committed step in the de novo pyrimidine nucleotide biosynthesis pathway.

Catalytic activity

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.

Features

Showing features for binding site.

129320406080100120140160180200220240260280
TypeIDPosition(s)Description
Binding site50carbamoyl phosphate (UniProtKB | ChEBI)
Binding site51carbamoyl phosphate (UniProtKB | ChEBI)
Binding site78L-aspartate (UniProtKB | ChEBI)
Binding site100carbamoyl phosphate (UniProtKB | ChEBI)
Binding site127carbamoyl phosphate (UniProtKB | ChEBI)
Binding site130carbamoyl phosphate (UniProtKB | ChEBI)
Binding site160L-aspartate (UniProtKB | ChEBI)
Binding site210L-aspartate (UniProtKB | ChEBI)
Binding site253carbamoyl phosphate (UniProtKB | ChEBI)
Binding site254carbamoyl phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionamino acid binding
Molecular Functionaspartate carbamoyltransferase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process
Biological Processamino acid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aspartate carbamoyltransferase
  • EC number
  • Alternative names
    • Aspartate transcarbamylase
      (ATCase
      )

Gene names

    • Name
      pyrB
    • Synonyms
      pyrB_1
    • ORF names
      ACR74_02700
      , AS572_05170
      , C0102_03430
      , CNH36_06395
      , DQU50_02065
      , DQU51_13975
      , E1948_05285
      , E1948_05845
      , EIG96_08505
      , EP54_08400
      , EQ90_08260
      , G0Z31_11010
      , G6Y24_13560
      , GO814_06455
      , GO941_13960
      , GO942_07155
      , GQX37_07100
      , GQX52_09655
      , GZ111_002270
      , HH313_001149
      , LB359_02695
      , M1K003_0041
      , NCTC10702_01897
      , NCTC13131_00442
      , NCTC7972_00751
      , QU38_12335
      , SAMEA1029512_00244
      , SAMEA1029528_00222
      , SAMEA1029536_02436
      , SAMEA1466929_01922
      , SAMEA1531725_01607
      , SAMEA1531744_01500
      , SAMEA2078260_01547
      , SAMEA2078588_01588
      , SAMEA2080344_01716
      , SAMEA2081063_01395
      , SAMEA4008575_01884
      , SAMEA4552975_00707
      , SAMEA70146418_01710
      , SAMEA70153168_01762
      , SAMEA70245418_01996

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • CA15
    • M121
    • MRSA_S20
    • SA-120
    • SA13-246
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus

Accessions

  • Primary accession
    A0A0D1HIF4
  • Secondary accessions
    • A0A1E8WW98

Proteomes

Subcellular Location

Interaction

Subunit

Heterododecamer (2C3:3R2) of six catalytic PyrB chains organized as two trimers (C3), and six regulatory PyrI chains organized as three dimers (R2).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-140Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Domain146-288Aspartate/ornithine carbamoyltransferase Asp/Orn-binding

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    293
  • Mass (Da)
    33,258
  • Last updated
    2015-04-29 v1
  • Checksum
    C4FC67C795DAFE27
MNHLLSMEHLSTDQIYKLIQKASQFKSGERQLPNFEGKYVANLFFENSTRTKCSFEMAELKLGLKTISFETSTSSVSKGESLYDTCKTLESIGCDLLVIRHPFNNYYEKLANINIPIANAGDGSGQHPTQSLLDLMTIYEEYGYFEGLNVLICGDIKNSRVARSNYHSLKALGANVMFNSPNAWIDDSLEAPYVNIDDVIETVDIVMLLRIQHERHGLAEETRFAADDYHQKHGLNEVRYNKLQEHAIVMHPAPVNRGVEIQSDLVEASKSRIFKQMENGVYLRMAVIDELLK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP023391
EMBL· GenBank· DDBJ
ATC71293.1
EMBL· GenBank· DDBJ
Genomic DNA
CACTPI010000001
EMBL· GenBank· DDBJ
CAA4077048.1
EMBL· GenBank· DDBJ
Genomic DNA
CACTOE010000002
EMBL· GenBank· DDBJ
CAA4078559.1
EMBL· GenBank· DDBJ
Genomic DNA
CACTPG010000022
EMBL· GenBank· DDBJ
CAA4177928.1
EMBL· GenBank· DDBJ
Genomic DNA
CACTQT010000007
EMBL· GenBank· DDBJ
CAA4376303.1
EMBL· GenBank· DDBJ
Genomic DNA
CACTWD010000007
EMBL· GenBank· DDBJ
CAA4682903.1
EMBL· GenBank· DDBJ
Genomic DNA
CACUNS010000008
EMBL· GenBank· DDBJ
CAA6088083.1
EMBL· GenBank· DDBJ
Genomic DNA
CACURZ010000008
EMBL· GenBank· DDBJ
CAA6361219.1
EMBL· GenBank· DDBJ
Genomic DNA
CAIGXB010000006
EMBL· GenBank· DDBJ
CAC5799120.1
EMBL· GenBank· DDBJ
Genomic DNA
CAIHOM010000001
EMBL· GenBank· DDBJ
CAC6989017.1
EMBL· GenBank· DDBJ
Genomic DNA
CAIIGD010000005
EMBL· GenBank· DDBJ
CAC8218551.1
EMBL· GenBank· DDBJ
Genomic DNA
CAIIGN010000006
EMBL· GenBank· DDBJ
CAC8240740.1
EMBL· GenBank· DDBJ
Genomic DNA
CAIIKR010000005
EMBL· GenBank· DDBJ
CAC8525434.1
EMBL· GenBank· DDBJ
Genomic DNA
UAUZ02000002
EMBL· GenBank· DDBJ
CAD7352974.1
EMBL· GenBank· DDBJ
Genomic DNA
BDVT01000001
EMBL· GenBank· DDBJ
GBV19079.1
EMBL· GenBank· DDBJ
Genomic DNA
JXIG01000629
EMBL· GenBank· DDBJ
KIT95716.1
EMBL· GenBank· DDBJ
Genomic DNA
LALJ01000013
EMBL· GenBank· DDBJ
KMR36667.1
EMBL· GenBank· DDBJ
Genomic DNA
LALQ01000035
EMBL· GenBank· DDBJ
KMR56848.1
EMBL· GenBank· DDBJ
Genomic DNA
LFVK01000002
EMBL· GenBank· DDBJ
KSA78140.1
EMBL· GenBank· DDBJ
Genomic DNA
JAIGOF010000005
EMBL· GenBank· DDBJ
MBX8594022.1
EMBL· GenBank· DDBJ
Genomic DNA
JAIUEN010000013
EMBL· GenBank· DDBJ
MCE3361268.1
EMBL· GenBank· DDBJ
Genomic DNA
WPTS01000025
EMBL· GenBank· DDBJ
MVK34779.1
EMBL· GenBank· DDBJ
Genomic DNA
WPVZ01000746
EMBL· GenBank· DDBJ
MVL46579.1
EMBL· GenBank· DDBJ
Genomic DNA
WPXC01000013
EMBL· GenBank· DDBJ
MVM10466.1
EMBL· GenBank· DDBJ
Genomic DNA
JAAJIY010000040
EMBL· GenBank· DDBJ
NGK22023.1
EMBL· GenBank· DDBJ
Genomic DNA
JAALTR010000324
EMBL· GenBank· DDBJ
NGW68484.1
EMBL· GenBank· DDBJ
Genomic DNA
JAANEC010000071
EMBL· GenBank· DDBJ
NUY12314.1
EMBL· GenBank· DDBJ
Genomic DNA
JAANDN010000088
EMBL· GenBank· DDBJ
NUY68897.1
EMBL· GenBank· DDBJ
Genomic DNA
LNJK01000002
EMBL· GenBank· DDBJ
OWT17831.1
EMBL· GenBank· DDBJ
Genomic DNA
PKSU01000002
EMBL· GenBank· DDBJ
PZL81271.1
EMBL· GenBank· DDBJ
Genomic DNA
CP038850
EMBL· GenBank· DDBJ
QCT56966.1
EMBL· GenBank· DDBJ
Genomic DNA
CP053070
EMBL· GenBank· DDBJ
QJR07305.1
EMBL· GenBank· DDBJ
Genomic DNA
RQSX01000178
EMBL· GenBank· DDBJ
RZH92987.1
EMBL· GenBank· DDBJ
Genomic DNA
UDJK01000008
EMBL· GenBank· DDBJ
SRC28418.1
EMBL· GenBank· DDBJ
Genomic DNA
UELG01000008
EMBL· GenBank· DDBJ
SRZ66123.1
EMBL· GenBank· DDBJ
Genomic DNA
UHAI01000002
EMBL· GenBank· DDBJ
SUK16280.1
EMBL· GenBank· DDBJ
Genomic DNA
UHBY01000003
EMBL· GenBank· DDBJ
SUL34606.1
EMBL· GenBank· DDBJ
Genomic DNA
UIOA01000008
EMBL· GenBank· DDBJ
SVG07994.1
EMBL· GenBank· DDBJ
Genomic DNA
QNXH01000001
EMBL· GenBank· DDBJ
TXL38569.1
EMBL· GenBank· DDBJ
Genomic DNA
QNXF01000002
EMBL· GenBank· DDBJ
TXL46624.1
EMBL· GenBank· DDBJ
Genomic DNA
CP152420
EMBL· GenBank· DDBJ
XAJ30860.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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