A0A0D1H2U8 · A0A0D1H2U8_STAAU
- Protein1,4-dihydroxy-2-naphthoyl-CoA synthase
- GenemenB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids273 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
Catalytic activity
- 2-succinylbenzoyl-CoA + H+ = 1,4-dihydroxy-2-naphthoyl-CoA + H2O
Cofactor
Pathway
Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7.
Quinol/quinone metabolism; menaquinone biosynthesis.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 34 | substrate; ligand shared between two neighboring subunits; in other chain | ||||
Sequence: R | ||||||
Binding site | 73-77 | substrate; ligand shared between two neighboring subunits; in other chain | ||||
Sequence: SGGDQ | ||||||
Binding site | 85 | substrate; ligand shared between two neighboring subunits; in other chain | ||||
Sequence: Y | ||||||
Site | 85 | Important for catalysis | ||||
Sequence: Y | ||||||
Binding site | 117-121 | substrate; ligand shared between two neighboring subunits; in other chain | ||||
Sequence: YAVGG | ||||||
Binding site | 142-144 | hydrogencarbonate (UniProtKB | ChEBI) | ||||
Sequence: QTG | ||||||
Binding site | 143 | substrate; ligand shared between two neighboring subunits; in other chain | ||||
Sequence: T | ||||||
Binding site | 149 | substrate; ligand shared between two neighboring subunits; in other chain | ||||
Sequence: S | ||||||
Binding site | 246 | substrate; ligand shared between two neighboring subunits | ||||
Sequence: Y | ||||||
Site | 246 | Important for catalysis | ||||
Sequence: Y | ||||||
Binding site | 261 | substrate; ligand shared between two neighboring subunits | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity | |
Biological Process | menaquinone biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name1,4-dihydroxy-2-naphthoyl-CoA synthase
- EC number
- Short namesDHNA-CoA synthase
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus
Accessions
- Primary accessionA0A0D1H2U8
- Secondary accessions
Proteomes
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 254-273 | Disordered | ||||
Sequence: GRDAFKEKRDPDFDQFPKFP |
Sequence similarities
Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length273
- Mass (Da)30,412
- Last updated2015-04-29 v1
- ChecksumDE689BC838E41DBE
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CAIIGN010000005 EMBL· GenBank· DDBJ | CAC8237822.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BDVT01000007 EMBL· GenBank· DDBJ | GBV20661.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JXIG01000623 EMBL· GenBank· DDBJ | KIT97321.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WPRH01000772 EMBL· GenBank· DDBJ | MVI57082.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WPVZ01000846 EMBL· GenBank· DDBJ | MVL46884.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAAJIY010000017 EMBL· GenBank· DDBJ | NGK21254.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAALWO010000006 EMBL· GenBank· DDBJ | NGV46339.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAALTR010000170 EMBL· GenBank· DDBJ | NGW67078.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAANDN010000108 EMBL· GenBank· DDBJ | NUY69368.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
PGWZ01000326 EMBL· GenBank· DDBJ | PPJ75511.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UHAP01000001 EMBL· GenBank· DDBJ | SUK39518.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UHAQ01000003 EMBL· GenBank· DDBJ | SUK84252.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QNXM01000003 EMBL· GenBank· DDBJ | TXL50575.1 EMBL· GenBank· DDBJ | Genomic DNA |