A0A0D0AP41 · A0A0D0AP41_9AGAM

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      CY34DRAFT_81550

Organism names

  • Taxonomic identifier
  • Strain
    • UH-Slu-Lm8-n1
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Agaricomycetidae > Boletales > Suillineae > Suillaceae > Suillus

Accessions

  • Primary accession
    A0A0D0AP41

Proteomes

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane50-72Helical
Transmembrane121-140Helical
Transmembrane146-166Helical
Transmembrane178-201Helical
Transmembrane213-232Helical
Transmembrane291-312Helical
Transmembrane332-350Helical
Transmembrane362-379Helical
Transmembrane391-415Helical
Transmembrane464-482Helical
Transmembrane574-596Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain54-490Major facilitator superfamily (MFS) profile
Region500-555Disordered

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    606
  • Mass (Da)
    66,414
  • Last updated
    2015-04-29 v1
  • Checksum
    AEF9F63CA6D25244
MTGHHPQSREPYISIPNRSYAEPHINSASTGPHDEEFVERGDATPAARASIVRVLALLCACSLSVGSHYASYTLGPLKSRLAREINTSNTEFSLLISAFSLNSTWTPLVGGMMASKLGTTLTSIIATGVIFFGQVLLLLGDIKGDVRLMVFGLFVFGFGVSPLAVVQESIIVRFFKSHGLGVSMALGLVAGKLASFISARTSFPLAERFGRHAPFYASTFLAALSLFINLVYMASSKWLIRGSGTVILEASEIRHEARRRSMYDLSEARALEKVAQKRHIRFKDIPKLGDIFWAYIGLNILCGTIWAPFTHLAANIFEKRYGLTEDAASTQASYLLVGSILLYPVTGFMIDRMKHPQAVLRMFMLSSVLTLLGYAWLVLPPTWTGTPSPAVAAFATGIGFSPLLLVVLVPQLVPFKFVSTTLGVHKSMEQTGATIFQTIAGLVLDGASPHQRAQKGDKYTTQQLLNVFFCFNILQLLGIIGLSHLDRRRRQAAETLENAVRDEADAERDLEEEPTFTGDEGDILASEIGPLSSPDPRKPLLGRRPRANSGASYFPSSCPSQGVRGHSEIRRGRIFVCLCVMLVGSAWVLFLSTAWLRLRSRQQRDL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KN835210
EMBL· GenBank· DDBJ
KIK43531.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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