A0A0C9PSD9 · A0A0C9PSD9_LACPA

Function

function

Provides the (R)-glutamate required for cell wall biosynthesis.
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site10-11substrate
Binding site42-43substrate
Active site73Proton donor/acceptor
Binding site74-75substrate
Active site184Proton donor/acceptor
Binding site185-186substrate
Binding site289-294substrate
Binding site322Mg2+ (UniProtKB | ChEBI)
Active site351Proton acceptor
Binding site351Mg2+ (UniProtKB | ChEBI)
Binding site352substrate
Binding site436-439substrate
Binding site459substrate
Binding site464-465substrate

GO annotations

AspectTerm
Molecular FunctiondITP diphosphatase activity
Molecular Functionglutamate racemase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processcell wall organization
Biological Processnucleotide metabolic process
Biological Processpeptidoglycan biosynthetic process
Biological Processpurine nucleoside triphosphate catabolic process
Biological Processregulation of cell shape

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )
  • Recommended name
    Glutamate racemase
  • EC number

Gene names

    • Name
      murI
    • ORF names
      LC0644_2390

Organism names

Accessions

  • Primary accession
    A0A0C9PSD9

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.
Belongs to the aspartate/glutamate racemases family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    484
  • Mass (Da)
    52,011
  • Last updated
    2015-05-27 v1
  • Checksum
    9D1BB5B14E10F2BE
MNKQPIGFIDSGVGGLTVVKEALHQLPAESSVYLGDQARLPYGPRPAEQVQAFTWQMVNFLLKKHIKMLVIACNTATAAALPLIKANLDIPVIGVIKPGSRAALKATQTGHIGIIATEGTVKSGAYVKALRAKAPKIRLTSLAAPKFVSLVESNEAHSPIAKRVVADTLQPLLHEDIDTLILGCTHYPILRPLIQNVMGDQVTLIDSGAETVNDVSMLLDYFDLANNSGDTPTHEYYTTGAPSMFDELGEAWLELTAPMHAKHVNIEAEADHAMATVPEAKGKTIVVASKNQGKIKEFKTMFEPAGITVKSLADFPSVPTVDETGTTFEENARQKADQYAEDLQLPVIADDSGLMVDALDGQPGIRSARYAGDGHNDAANNAKLLAALADVPEDDRTATFHTTLVLAKPDHPEADLVVHGDVSGLITAIPRGTDGFGYDPFFFVPALGKTMAEMTAEEKNQISHRGNAMRALEDVWQTWLEANG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BAYM01000376
EMBL· GenBank· DDBJ
GAN37801.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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