A0A0C7KJN1 · A0A0C7KJN1_KLEPN

  • Protein
    H(+)/Cl(-) exchange transporter ClcA
  • Gene
    clcA_2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.

Catalytic activity

Features

Showing features for binding site, site.

150350100150200250300350400450500
TypeIDPosition(s)Description
Binding site138chloride (UniProtKB | ChEBI)
Site179Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H+ and Cl- transport
Site234Mediates proton transfer from the protein to the inner aqueous phase
Binding site387chloride (UniProtKB | ChEBI)
Binding site388chloride (UniProtKB | ChEBI)
Binding site476chloride (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionantiporter activity
Molecular Functionvoltage-gated chloride channel activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    H(+)/Cl(-) exchange transporter ClcA

Gene names

    • Name
      clcA_2
    • Synonyms
      clcA
      , clcA_1
      , eriC
    • ORF names
      NCTC13443_01785
      , SAMEA3499901_00741
      , SAMEA3515122_02936
      , SAMEA3538828_00781

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • NCTC13443
    • EuSCAPE_AT029
    • EuSCAPE_HU047
    • EuSCAPE_IT093
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella

Accessions

  • Primary accession
    A0A0C7KJN1

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane64-84Helical
Transmembrane107-128Helical
Transmembrane159-177Helical
Transmembrane208-232Helical
Transmembrane244-263Helical
Transmembrane283-302Helical
Transmembrane322-339Helical
Transmembrane359-379Helical
Transmembrane391-413Helical
Transmembrane419-444Helical
Transmembrane451-470Helical

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    503
  • Mass (Da)
    53,844
  • Last updated
    2015-04-29 v1
  • Checksum
    F44C92A275D9F0B6
MCRKGIFLTTQRAGTAKMPLSSFVLPIIDNGMKAETPSFEAHQFVRVRRGDAVRRLIQRDKTPLAVLFMAAVVGTLAGLVGVAFEKSVNWVQNQRIGALAQVADHWYLVWPLAFILSALLAMVGYFLVRRFAPEAGGSGIPEIEGALEELRPVRWWRVLPVKFVGGMGTLGAGMVLGREGPMVQLGGNIGRMVLDVFRMRSPEARHTLLATGAASGLSAAFNAPLAGILFIIEEMRPQFRYNLISIKAVFTGVIMSSIVFRIFNGEAAIIEVGKLSNAPVNTLWLYLVLGMLFGCFGPLFNFLVLRTQDLFQRIHGGNIKKWVLIGGLIGGLCGLLGLMQPSAVGGGFNLIPIAAAGNFSVGLLLFIFIARVLTTLICFSSGAPGGIFAPMLALGTLLGTAFGMAAIPLFPAYHLDAGTFAIAGMGALLAASVRAPLTGIVLVLEMTDNYQLILPMIITCLGATLLAQFLGGKPLYSTILQRTLAKQEAEQAAKAQQAPRENT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
UGKT01000001
EMBL· GenBank· DDBJ
STT01468.1
EMBL· GenBank· DDBJ
Genomic DNA
UKGE01000003
EMBL· GenBank· DDBJ
SXN29748.1
EMBL· GenBank· DDBJ
Genomic DNA
UKUT01000006
EMBL· GenBank· DDBJ
SYH32953.1
EMBL· GenBank· DDBJ
Genomic DNA
ULCI01000003
EMBL· GenBank· DDBJ
SYR31292.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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