A0A0C7KJN1 · A0A0C7KJN1_KLEPN
- ProteinH(+)/Cl(-) exchange transporter ClcA
- GeneclcA_2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids503 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.
Catalytic activity
- 2 chloride(in) + H+(out) = 2 chloride(out) + H+(in)
2 chloride (in)CHEBI:17996+ H+ (out)CHEBI:15378= 2 chloride (out)CHEBI:17996+ H+ (in)CHEBI:15378
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 138 | chloride (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Site | 179 | Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H+ and Cl- transport | ||||
Sequence: E | ||||||
Site | 234 | Mediates proton transfer from the protein to the inner aqueous phase | ||||
Sequence: E | ||||||
Binding site | 387 | chloride (UniProtKB | ChEBI) | ||||
Sequence: I | ||||||
Binding site | 388 | chloride (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 476 | chloride (UniProtKB | ChEBI) | ||||
Sequence: Y |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | antiporter activity | |
Molecular Function | voltage-gated chloride channel activity |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameH(+)/Cl(-) exchange transporter ClcA
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella
Accessions
- Primary accessionA0A0C7KJN1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 64-84 | Helical | ||||
Sequence: LAVLFMAAVVGTLAGLVGVAF | ||||||
Transmembrane | 107-128 | Helical | ||||
Sequence: YLVWPLAFILSALLAMVGYFLV | ||||||
Transmembrane | 159-177 | Helical | ||||
Sequence: LPVKFVGGMGTLGAGMVLG | ||||||
Transmembrane | 208-232 | Helical | ||||
Sequence: LLATGAASGLSAAFNAPLAGILFII | ||||||
Transmembrane | 244-263 | Helical | ||||
Sequence: ISIKAVFTGVIMSSIVFRIF | ||||||
Transmembrane | 283-302 | Helical | ||||
Sequence: LWLYLVLGMLFGCFGPLFNF | ||||||
Transmembrane | 322-339 | Helical | ||||
Sequence: WVLIGGLIGGLCGLLGLM | ||||||
Transmembrane | 359-379 | Helical | ||||
Sequence: FSVGLLLFIFIARVLTTLICF | ||||||
Transmembrane | 391-413 | Helical | ||||
Sequence: MLALGTLLGTAFGMAAIPLFPAY | ||||||
Transmembrane | 419-444 | Helical | ||||
Sequence: TFAIAGMGALLAASVRAPLTGIVLVL | ||||||
Transmembrane | 451-470 | Helical | ||||
Sequence: QLILPMIITCLGATLLAQFL |
Keywords
- Cellular component
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length503
- Mass (Da)53,844
- Last updated2015-04-29 v1
- ChecksumF44C92A275D9F0B6
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
UGKT01000001 EMBL· GenBank· DDBJ | STT01468.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UKGE01000003 EMBL· GenBank· DDBJ | SXN29748.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UKUT01000006 EMBL· GenBank· DDBJ | SYH32953.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
ULCI01000003 EMBL· GenBank· DDBJ | SYR31292.1 EMBL· GenBank· DDBJ | Genomic DNA |