A0A0C5WVQ7 · A0A0C5WVQ7_9GAMM
- ProteinPimeloyl-[acyl-carrier protein] methyl ester esterase
- GenebioH
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids254 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
Catalytic activity
- 6-carboxyhexanoyl-[ACP] methyl ester + H2O = 6-carboxyhexanoyl-[ACP] + methanol + H+
Pathway
Cofactor biosynthesis; biotin biosynthesis.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 22 | substrate | ||||
Sequence: W | ||||||
Active site | 82 | Nucleophile | ||||
Sequence: S | ||||||
Binding site | 82-83 | substrate | ||||
Sequence: SL | ||||||
Binding site | 143-147 | substrate | ||||
Sequence: FMALQ | ||||||
Active site | 207 | |||||
Sequence: D | ||||||
Active site | 235 | |||||
Sequence: H | ||||||
Binding site | 235 | substrate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | pimelyl-[acyl-carrier protein] methyl ester esterase activity | |
Biological Process | biotin biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePimeloyl-[acyl-carrier protein] methyl ester esterase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Vibrionales > Vibrionaceae > Photobacterium
Accessions
- Primary accessionA0A0C5WVQ7
Proteomes
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 16-242 | AB hydrolase-1 | ||||
Sequence: LLLIHGWGMNGAVWQQVLPVLAQHYRVHVVDLPGYGHSRHHPAADVDEMADMLLAQAPAQATWLGWSLGGLVATAAALQAPGRVQQLVTVASSPRFAAEETWRGIKPQVLDEFRRQLDLDFRATIERFMALQAMGSRTARQDIRQLKEAVLSRPEPNPAALALGLDILARVDLRPELAAVSPPWLRLYGRLDSLVPAKVARDLDQLAPQSQRHVFAGASHAPFISHP |
Sequence similarities
Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length254
- Mass (Da)27,969
- Last updated2015-04-29 v1
- Checksum35A6B42C3BF78C4A
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP005974 EMBL· GenBank· DDBJ | AJR07180.1 EMBL· GenBank· DDBJ | Genomic DNA |