A0A0C5QC30 · A0A0C5QC30_HYDIN

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • JR16
    • JR17
    • JR18
    • JR19
    • JR20
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Cervidae > Hydropotinae > Hydropotes

Accessions

  • Primary accession
    A0A0C5QC30

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane45-66Helical
Transmembrane87-111Helical
Transmembrane131-154Helical
Transmembrane166-193Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-226Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    226
  • Mass (Da)
    24,359
  • Last updated
    2015-04-29 v1
  • Checksum
    917C405CB1C1B635
LYLLFGAWAGMVGTALSLLIRAELGQPGTLLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEV

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue226

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KP100307
EMBL· GenBank· DDBJ
AJQ25054.1
EMBL· GenBank· DDBJ
Genomic DNA
KP100308
EMBL· GenBank· DDBJ
AJQ25055.1
EMBL· GenBank· DDBJ
Genomic DNA
KP100309
EMBL· GenBank· DDBJ
AJQ25056.1
EMBL· GenBank· DDBJ
Genomic DNA
KP100310
EMBL· GenBank· DDBJ
AJQ25057.1
EMBL· GenBank· DDBJ
Genomic DNA
KP100311
EMBL· GenBank· DDBJ
AJQ25058.1
EMBL· GenBank· DDBJ
Genomic DNA
KP100312
EMBL· GenBank· DDBJ
AJQ25059.1
EMBL· GenBank· DDBJ
Genomic DNA
KP100313
EMBL· GenBank· DDBJ
AJQ25060.1
EMBL· GenBank· DDBJ
Genomic DNA
KP100314
EMBL· GenBank· DDBJ
AJQ25061.1
EMBL· GenBank· DDBJ
Genomic DNA
KP100315
EMBL· GenBank· DDBJ
AJQ25062.1
EMBL· GenBank· DDBJ
Genomic DNA
KP100316
EMBL· GenBank· DDBJ
AJQ25063.1
EMBL· GenBank· DDBJ
Genomic DNA
KP100317
EMBL· GenBank· DDBJ
AJQ25064.1
EMBL· GenBank· DDBJ
Genomic DNA
KP100318
EMBL· GenBank· DDBJ
AJQ25065.1
EMBL· GenBank· DDBJ
Genomic DNA
KP100320
EMBL· GenBank· DDBJ
AJQ25067.1
EMBL· GenBank· DDBJ
Genomic DNA
KP100321
EMBL· GenBank· DDBJ
AJQ25068.1
EMBL· GenBank· DDBJ
Genomic DNA
KP100322
EMBL· GenBank· DDBJ
AJQ25069.1
EMBL· GenBank· DDBJ
Genomic DNA
KP100323
EMBL· GenBank· DDBJ
AJQ25070.1
EMBL· GenBank· DDBJ
Genomic DNA
KP100324
EMBL· GenBank· DDBJ
AJQ25071.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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