A0A0C5CHH3 · A0A0C5CHH3_9FLAV
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids3391 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
function
Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.
Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 1526 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: H | ||||||
Active site | 1550 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: D | ||||||
Active site | 1610 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: S | ||||||
Binding site | 2547 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 2577 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 2578 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: W | ||||||
Binding site | 2595 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 2596 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 2622 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 2623 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 2710 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 2929 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 2933 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 2938 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 2941 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 3203 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 3219 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 3338 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Organism names
- Organism
- Strains
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Orthoflavivirus > Orthoflavivirus denguei > Dengue virus
Accessions
- Primary accessionA0A0C5CHH3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Multi-pass membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Membrane ; Multi-pass membrane protein
Membrane ; Peripheral membrane protein
Virion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 249-272 | Helical | ||||
Sequence: IMAAILAYTIGTTYFQRVLIFILL | ||||||
Transmembrane | 722-748 | Helical | ||||
Sequence: AIYGAAFSGVSWTMKILIGVVITWIGM | ||||||
Transmembrane | 754-775 | Helical | ||||
Sequence: SLSVSLVLVGVVTLYLGVMVQA | ||||||
Transmembrane | 1159-1177 | Helical | ||||
Sequence: AILLVAVSFVTLITGNMSF | ||||||
Transmembrane | 1197-1220 | Helical | ||||
Sequence: MGVTYLALLAAFKVRPTFAAGLLL | ||||||
Transmembrane | 1272-1292 | Helical | ||||
Sequence: LAVTIMAILCVPNAVILQNAW | ||||||
Transmembrane | 1448-1469 | Helical | ||||
Sequence: LLVISGLFPVSIPITAAAWYLW | ||||||
Transmembrane | 2148-2167 | Helical | ||||
Sequence: LLLLTLLAAVTGGIFLFLMS | ||||||
Transmembrane | 2174-2191 | Helical | ||||
Sequence: MTLGMCCIITASILLWYA | ||||||
Transmembrane | 2197-2214 | Helical | ||||
Sequence: WIAASIILEFFLIVLLIP | ||||||
Transmembrane | 2226-2243 | Helical | ||||
Sequence: QLTYVVIAILTVVAATMA |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 283↔310 | |||||
Sequence: CIGISNRDFVEGVSGGSWVDIVLEHGSC | ||||||
Disulfide bond | 340↔396 | |||||
Sequence: CIEAKLTNTTTASRCPTQGEPSLNEEQDKRFVCKHSMVDRGWGNGCGLFGKGGIVTC | ||||||
Disulfide bond | 354↔385 | |||||
Sequence: CPTQGEPSLNEEQDKRFVCKHSMVDRGWGNGC | ||||||
Disulfide bond | 372↔401 | |||||
Sequence: CKHSMVDRGWGNGCGLFGKGGIVTCAMFTC | ||||||
Disulfide bond | 465↔565 | |||||
Sequence: CSPRTGLDFNEMVLLQMENKAWLVHRQWFLDLPLPWLPGADTQGSNWIQKETLVTFKNPHAKKQDVVVLGSQEGAMHTALTGATEIQMSSGNLLFTGHLKC | ||||||
Disulfide bond | 582↔613 | |||||
Sequence: CTGKFKVVKEIAETQHGTIVIRVQYEGDGSPC |
Keywords
- PTM
Interaction
Subunit
Interacts (via N-terminus) with serine protease NS3.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1346-1475 | Flavivirus NS2B | ||||
Sequence: SWPLNEAIMAVGMVSILASSLLKNDIPMTGPLVAGGLLTVCYVLTGRSADLELERAADVRWEEQAEISGSSPILSITISEDGSMSIKNEEEEQTLTILIRTGLLVISGLFPVSIPITAAAWYLWEVKKQR | ||||||
Domain | 1476-1653 | Peptidase S7 | ||||
Sequence: AGVLWDVPSPPPVGKAELEDGAYRIKQKGILGYSQIGAGVYKEGTFHTMWHVTRGAVLMHKGKRIEPSWADVKKDLISYGGGWKLEGEWKEGEEVQVLALEPGKNPRAVQTKPGLFKTNTGTIGAVSLDFSPGTSGSPIVDKKGKVVGLYGNGVVTRSGTYVSAIAQTEKSIEDNPEI | ||||||
Domain | 1655-1811 | Helicase ATP-binding | ||||
Sequence: DDIFRKKRLTIMDLHPGAGKTKRYLPAIVREAIKRGLRTLILAPTRVVAAEMEEALRGLPIRYQTPAIRAEHTGREIVDLMCHATFTMRLLSPIRVPNYNLIIMDEAHFTDPASIAARGYISTRVEMGEAAGIFMTATPPGSRDPFPQSNAPIMDEE | ||||||
Domain | 1821-1988 | Helicase C-terminal | ||||
Sequence: SGHEWVTDFKGKTVWFVPSIKAGNDIAACLRKNGKKVIQLSRKTFDSEYIKTRTNDWDFVVTTDISEMGANFKAERVIDPRRCMKPVILTDGEERVILAGPMPVTHSSAAQRRGRVGRNPKNENDQYIYMGEPLENDEDCAHWKEAKMLLDNISTPEGIIPSMFEPER | ||||||
Domain | 2493-2755 | MRNA cap 0-1 NS5-type MT | ||||
Sequence: TGNTGETLGEKWKNRLNALGKSEFQIYKKSGIQEVDRTLAKEGIKRGETDHHAVSRGSAKLRWFVERNLVTPEGKVVDLGCGRGGWSYYCGGLKNVKEVKGLTKGGPGHEEPIPMSTYGWNLVRLQSGVDVFFTPPEKCDTLLCDIGESSPNPTVEAGRTLRVLNLVENWLNNNTQFCIKVLNPYMPSVIEKMEALQRKYGGALVRNPLSRNSTHEMYWVSNASGNIVSSVNMISRMLINRFTMRHKKATYEPDVDLGSGTRN | ||||||
Domain | 3019-3168 | RdRp catalytic | ||||
Sequence: GAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRPTPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQQLTVTEEIAVKNWLVRVGRERLSRMAISGDDCVVKPLDDRFASA |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length3,391
- Mass (Da)379,404
- Last updated2015-04-29 v1
- ChecksumA248EE52864BCDD6
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KP012546 EMBL· GenBank· DDBJ | AJO16118.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
KT187553 EMBL· GenBank· DDBJ | ALP06110.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
KT187555 EMBL· GenBank· DDBJ | ALP06112.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
KT187556 EMBL· GenBank· DDBJ | ALP06113.1 EMBL· GenBank· DDBJ | Genomic RNA | ||
KT187558 EMBL· GenBank· DDBJ | ALP06115.1 EMBL· GenBank· DDBJ | Genomic RNA |