A0A0C5CGB8 · A0A0C5CGB8_9CARA
- Proteinisocitrate dehydrogenase (NADP(+))
- GeneIDH1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids408 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Cofactor
Protein has several cofactor binding sites:
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Binds 1 Mg2+ or Mn2+ ion per subunit.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 74-76 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 76 | D-threo-isocitrate (UniProtKB | ChEBI) | |||
Binding site | 81 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 93-99 | D-threo-isocitrate (UniProtKB | ChEBI) | |||
Binding site | 108 | D-threo-isocitrate (UniProtKB | ChEBI) | |||
Binding site | 131 | D-threo-isocitrate (UniProtKB | ChEBI) | |||
Site | 138 | Critical for catalysis | |||
Site | 209 | Critical for catalysis | |||
Binding site | 249 | Mn2+ (UniProtKB | ChEBI) | |||
Binding site | 257 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 272 | Mn2+ (UniProtKB | ChEBI) | |||
Binding site | 307-312 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 325 | NADP+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | mitochondrion | |
Cellular Component | peroxisome | |
Molecular Function | isocitrate dehydrogenase (NADP+) activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | NAD binding | |
Biological Process | glyoxylate cycle | |
Biological Process | isocitrate metabolic process | |
Biological Process | NADP metabolic process | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameisocitrate dehydrogenase (NADP(+))
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Adephaga > Caraboidea > Carabidae > Trechinae > Pogonini > Pogonus
Accessions
- Primary accessionA0A0C5CGB8
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Sequence
- Sequence statusFragment
- Length408
- Mass (Da)46,390
- Last updated2015-04-29 v1
- MD5 Checksum9C46085694E1799171AEF76D836F9C17
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 408 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KJ371238 EMBL· GenBank· DDBJ | AJO53428.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ371239 EMBL· GenBank· DDBJ | AJO53429.1 EMBL· GenBank· DDBJ | Genomic DNA |