A0A0C5CGB8 · A0A0C5CGB8_9CARA

  • Protein
    isocitrate dehydrogenase (NADP(+))
  • Gene
    IDH1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mg2+ or Mn2+ ion per subunit.
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site, site.

140850100150200250300350400
Type
IDPosition(s)Description
Binding site74-76NADP+ (UniProtKB | ChEBI)
Binding site76D-threo-isocitrate (UniProtKB | ChEBI)
Binding site81NADP+ (UniProtKB | ChEBI)
Binding site93-99D-threo-isocitrate (UniProtKB | ChEBI)
Binding site108D-threo-isocitrate (UniProtKB | ChEBI)
Binding site131D-threo-isocitrate (UniProtKB | ChEBI)
Site138Critical for catalysis
Site209Critical for catalysis
Binding site249Mn2+ (UniProtKB | ChEBI)
Binding site257NADP+ (UniProtKB | ChEBI)
Binding site272Mn2+ (UniProtKB | ChEBI)
Binding site307-312NADP+ (UniProtKB | ChEBI)
Binding site325NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmitochondrion
Cellular Componentperoxisome
Molecular Functionisocitrate dehydrogenase (NADP+) activity
Molecular Functionmagnesium ion binding
Molecular FunctionNAD binding
Biological Processglyoxylate cycle
Biological Processisocitrate metabolic process
Biological ProcessNADP metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    isocitrate dehydrogenase (NADP(+))
  • EC number
  • Alternative names
    • NADP(+)-specific ICDH
    • Oxalosuccinate decarboxylase

Gene names

    • Name
      IDH1

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • Pc2311-1
    • Pc2311-2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Adephaga > Caraboidea > Carabidae > Trechinae > Pogonini > Pogonus

Accessions

  • Primary accession
    A0A0C5CGB8

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-398Isopropylmalate dehydrogenase-like

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    408
  • Mass (Da)
    46,390
  • Last updated
    2015-04-29 v1
  • MD5 Checksum
    9C46085694E1799171AEF76D836F9C17
MAKIKAGPVVDILGDEMTRIIWDSIKEKLILPFLDIELHTYDLGIENRDKTEDKVTVDCAEAIKKYNVGIKCATITPDENRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVTCWNQPIIIGRHAHADQYKATDFVVPGKGKLELVYTPENGEPTRYIVHEYKGPGVAMGMFNTDESIIAFAHSSFQYALNRNYPLYLSTKNTILKRYDGRFKDIFQDIYEREYKTAFEAKKIWYEHRLIDDMVAYAMKSDGGFVWACKNYDGDVQSDSVAQGYGSLGLMTSVLICPDGKTVESEAAHGTVTRHYRLYQKGQETSTNPIASIFAWTRGLLHRAKLDKNTALEKFAKDLETVCIETIESGFMTKDLAICIKGMSNVKRSDYLETFEFMNKLAENLKKKVSA

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue408

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KJ371238
EMBL· GenBank· DDBJ
AJO53428.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ371239
EMBL· GenBank· DDBJ
AJO53429.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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