A0A0C4UQW3 · A0A0C4UQW3_9REOV

Function

function

VP5 protein is one of the two proteins (with VP2) which constitute the virus particle outer capsid. Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. Permeabilization activity is probably negatively regulated by VP2 and is triggered by endosomal degradation of VP2 and exposure to low pH.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentviral capsid
Molecular Functionstructural molecule activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Outer capsid protein VP5

Organism names

  • Taxonomic identifier
  • Strains
    • ISR2006/02
    • ISR2006/04
    • ISR2006/06
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Duplornaviricota > Resentoviricetes > Reovirales > Sedoreoviridae > Orbivirus > Epizootic hemorrhagic disease virus

Accessions

  • Primary accession
    A0A0C4UQW3

Subcellular Location

Keywords

Family & Domains

Features

Showing features for coiled coil.

TypeIDPosition(s)Description
Coiled coil162-189

Sequence similarities

Belongs to the orbivirus VP5 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    527
  • Mass (Da)
    58,987
  • Last updated
    2015-04-29 v1
  • Checksum
    3C279B7516965836
MGKIIKKLSKVGKKIGDALTSNTAQRIYKTIGKAAERFAESEIGSAAIDGLIQGTVQSVITGESYGETVKQAVLLNVLGAGDSISDPLSPGERGMQIKIQELEDEEKGNAIRQRHNDRIIQLFSNDLDDVYRFATAQIADDELKDNQYEILEKAVKSYGKVIGEEERRLKQLRDALQKEISDRSKVEREMVIEYRNKIEALRGAIEIESEGMQEEAIQEIASMSAEILEAASEEVPFFGAGMATAIASARAIEGGYKLKKVINALSGIDLSHLRTPRIEPQTLEAILRTPAGTEIDDVKLVTGIAAKIEAVEDNHHEVEHIEKQILPQIKQAMKEDHEAIGSEETKRILPKTAMRFKVPLSQQPQIHIYAAPWDSDDVFILHCVAPHHANESFFMGFDLELEYVFYEDLTRHWHALGGAQEATGRTFREVYREFFSLALQQEGASVIHQRRLARSRGAHPIYLGATHYEVSYSQLKRNALKLVNDAELQVHVLRGPKHFQRRAIMGAIKVGVSLIGEIDLPEFMRYA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KM391726
EMBL· GenBank· DDBJ
AIY25172.1
EMBL· GenBank· DDBJ
Genomic RNA
KM391734
EMBL· GenBank· DDBJ
AIY25173.1
EMBL· GenBank· DDBJ
Genomic RNA
KM391753
EMBL· GenBank· DDBJ
AIY25174.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

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