A0A0C4PNS1 · A0A0C4PNS1_9FLAV

  • Protein
    Genome polyprotein
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Organism
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.

Catalytic activity

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site1551Charge relay system; for serine protease NS3 activity
Active site1575Charge relay system; for serine protease NS3 activity
Active site1635Charge relay system; for serine protease NS3 activity
Binding site2535GTP (UniProtKB | ChEBI)
Binding site2538GTP (UniProtKB | ChEBI)
Binding site2539GTP (UniProtKB | ChEBI)
Binding site2541GTP (UniProtKB | ChEBI)
Binding site2546GTP (UniProtKB | ChEBI)
Binding site2550GTP (UniProtKB | ChEBI)
Binding site2578S-adenosyl-L-homocysteine (UniProtKB | ChEBI)
Binding site2578S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site2608S-adenosyl-L-homocysteine (UniProtKB | ChEBI)
Binding site2608S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site2609S-adenosyl-L-homocysteine (UniProtKB | ChEBI)
Binding site2609S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site2626S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site2627S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site2633S-adenosyl-L-homocysteine (UniProtKB | ChEBI)
Binding site2653S-adenosyl-L-homocysteine (UniProtKB | ChEBI)
Binding site2653S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site2654S-adenosyl-L-homocysteine (UniProtKB | ChEBI)
Binding site2654S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site2735GTP (UniProtKB | ChEBI)
Binding site2737GTP (UniProtKB | ChEBI)
Binding site2742S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site2962Zn2+ 1 (UniProtKB | ChEBI)
Binding site2966Zn2+ 1 (UniProtKB | ChEBI)
Binding site2971Zn2+ 1 (UniProtKB | ChEBI)
Binding site2974Zn2+ 1 (UniProtKB | ChEBI)
Binding site3239Zn2+ 2 (UniProtKB | ChEBI)
Binding site3255Zn2+ 2 (UniProtKB | ChEBI)
Binding site3374Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentextracellular region
Cellular Componenthost cell endoplasmic reticulum membrane
Cellular Componenthost cell nucleus
Cellular Componentmembrane
Cellular Componentviral capsid
Cellular Componentvirion membrane
Molecular FunctionATP binding
Molecular Functiondouble-stranded RNA binding
Molecular FunctionGTP binding
Molecular Functionmetal ion binding
Molecular FunctionmRNA (nucleoside-2'-O-)-methyltransferase activity
Molecular FunctionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
Molecular Functionprotein dimerization activity
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionRNA helicase activity
Molecular FunctionRNA-dependent RNA polymerase activity
Molecular Functionserine-type endopeptidase activity
Molecular Functionstructural molecule activity
Biological Processfusion of virus membrane with host endosome membrane
Biological Processproteolysis
Biological Processsymbiont entry into host cell
Biological Processsymbiont-mediated suppression of host innate immune response
Biological Processsymbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity
Biological Processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
Biological Processviral RNA genome replication
Biological Processvirion attachment to host cell
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Genome polyprotein

Organism names

  • Taxonomic identifier
  • Organism
    Ntaya virus
  • Strain
    • Original
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Orthoflavivirus > Orthoflavivirus ntayaense

Accessions

  • Primary accession
    A0A0C4PNS1

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Endoplasmic reticulum membrane
; Peripheral membrane protein
Endoplasmic reticulum membrane
; Peripheral membrane protein
Host endoplasmic reticulum membrane
; Multi-pass membrane protein
Host endoplasmic reticulum membrane
; Peripheral membrane protein
Host endoplasmic reticulum membrane
; Peripheral membrane protein
Host nucleus
Membrane
; Multi-pass membrane protein
Membrane
; Peripheral membrane protein
Secreted
Virion membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane742-763Helical
Transmembrane770-790Helical
Transmembrane1178-1196Helical
Transmembrane1247-1263Helical
Transmembrane1304-1325Helical
Transmembrane1337-1363Helical
Transmembrane1375-1393Helical
Transmembrane1399-1423Helical
Transmembrane2173-2191Helical
Transmembrane2198-2216Helical
Transmembrane2222-2239Helical
Transmembrane2251-2268Helical
Transmembrane2331-2350Helical
Transmembrane2362-2391Helical
Transmembrane2440-2458Helical

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond292↔319
Disulfide bond349↔405
Disulfide bond363↔394
Disulfide bond381↔410
Disulfide bond479↔577
Disulfide bond594↔625

Keywords

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1370-1500Flavivirus NS2B
Domain1501-1678Peptidase S7
Domain1681-1837Helicase ATP-binding
Domain1848-2013Helicase C-terminal
Domain2523-2788MRNA cap 0-1 NS5-type MT
Domain3052-3204RdRp catalytic

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    3,427
  • Mass (Da)
    380,774
  • Last updated
    2015-04-29 v1
  • Checksum
    E43988E0B7EEBA26
MSNKKPGRPGATRVVNMLKRGASRGNPISRIKRMLDGLFKGIGPIRIVLAFLTFFKFTALKPTAGLLRRWKIVGVAEATRHLKSFRKDIGQMLDGLNKRGKKKRGGSTGGLLLIISFSCACALKVGSYNGKPLITVNQTDVQNPIELPTAQGTNRCMVKALDVGLMCPDDITYLCPKLENGYDPEDIDCWCNGTEVYIHYGRCTPTRHARRLRRAITVHHHGESLLEAKNTPWMDSTKATKYLTKVENWAIRNPGYALAAAIVGWNLGTTKAQKIIFTIMLMLIAPAYSFNCLGMQNRDFVEGVNGVEWIDVVMEGGSCVTITAKDKPTIDVKMMNMEATDLALVRSYCYEPKITDVSTEPRCPTMGEAHNTKASSQDYVCKKGLTDRGWGNGCGLFGKGSIHTCAKFECTHKAEGRVVQKENIQFEVAVFVHGSTEAGTYNNYSIQQSLKHAARFVITPKAPVHTAELSEYGTVTLECEPRSGLDMSQFYVMTMNMKSWLVNRDWFHDLNLPWTGSAAGNWQNRESLVEFEEAHATKQSVVALASQEGALHAALAGAIPVKYTSSKLEMTSGHLKCRVKLQGLKLKGMTYPMCSNKFSLARNPTDTGHGTVVVKLSYAGSDGPCRIPISMTANLQDLTPIGRMITVNPYVSTSSTGTKVIVELEPPFGDSFILVGSGENQIKYQWHKSGSSIGKAFVSTLKGAQRMVALGDTAWDFGSVGGFFTSLGKGIHQVFGTAFRSLFGGMSWITQGLLGILMLWMGLNARDRSISITFLAVGGVLVFLATNVHADTGCALDMSRKELKCGSGIFVFNDVETWRDNYKYYPATPRNLAKVIVESYRKGICGVRSVSRLEHNMWDSIKHELNAILEDNGEDLTVVVEPIVGRLRSTQRRLTWTEEELEYGWKKWGKTLFTSPGMSNRTFVVDGPKTKECPDDKRAWNSLYVEDFGFGITSTRVWMGLRKVNTTDCDTAVMGTAVKGDVAVHSDLSYWIESRNNKTWKLERAVLGEVKSCTWPETHTLWSESVMESDLIIPVTIAGPRSRHNMRPGYKVQNSGPWDEKEITIDFDYCPGTTVKVTSTCHDRAASARTTTASGKLIQDWCCRSCTLPPLRYMTKSGCWYAMEIRPTTHGEDTLIKSKVSAFRGDGMEPFQLGVLLMFVATQEVLRKRWTAGMALPAMLMFLCALIFGGITYMDLVRYVILVAAAFAESNSGGDIVHLALIAAFKIQPGLLVAYSLKRKWSNQESVLVGIALSMLTLAMQDWDMTIPSLLNSGAAAWLLLRAVSEGTVSAVCIPVLGMLAPGLRIAGIDVVRIGLLIIGIMSLMRERNNAAAKKKGGLLIGLALAESGLISPLVYAGLTLALKPNMRRGWPVSEALTAVGLTFALAGGIAHFDEGNMAIPLAVGGIMLVVAVVTGFTTDLWLEKAGEMTWSEEAQITGSSQRYDVEIDSDGNMRLLNDPGIPFSVWALRTGLILLSAYNPYLLPVTLGAYWLTVKAPKRSGAIWDVPAPKERRKAEISTGVFRIMARGIFGKYQAGVGVMYEGVFHTMWHVTNGATIDVGDGCLVPYWASVREDLISYGGPWKLGKKWNGVDEVQVVVVQPGKPATNVQTKPGIFRTHAGEVGAVTLDYPTGTSGSPIIDKEGNIIGLYGNGILVGAGNFVSMISQGNRMEEEIPQVFNDDMLRKRQLTVLDLHPGSGKTRKVLPQIVKAAIEKRLRTAILAPTRVVAAEIAEALKEYPIRYLTPAVKREHTGTEIIDVMCHATLTARLLTPQRVPNYNLFVMDEAHFTDPASIAARGYISTKVDLGEAAAIFMTATPPGTRDAFPDSNSPIMDVEEQIPDRAWNSGYDWITDYTGKTVWFVPSVKMGNEIAMCLTKAGKKVIQLNRKSFDNEYPKCKTGDWDFVVTTDISEMGANFGASRVIDSRKCIKPVIIEDGEGSVQLNGPVPITAASAAQRRGRVGRNPVQVGDEYHFAGPTSEDDHDFAHWKEAKILLDNINLPNGLVAQLYEPEREKVFSIDGEYRLRTEQRKNFVEFLRTGDLPVWISHKLADAGIAYNDRRWCFDGPTVNTVLEDNNPVELWTKTGEKKILRPRWRDGRLWADHQALKSFKEFACGKRSAIGVFEVVKMLPEHFAHRMGESMDNIYMLSTAERGSRAHREALEELPETLETILLITMMALASCGVFLFFVQRRGLGKTGLGAMILMTATVLLWIAEVQPQKIAGILLVSLLLMIVLIPEPERQRSQTDSHLAVFMIVVLLIVGAVASNEMGWLEQTKRDISGLFGRTQEQRTEKWDFPWPDLRPATAWAAYAGATTLLTPLLKHLIVTEYVNFSLMAVTAQAGALFGLGKGMPFVSMDLSVPLLLLGCWGQFTMTSTLTTIVLLIVHYAFLVPGWQAEAMRAAQRRTAAGVMKNPVVDGIVATDIPDLDASTPITEKKFGQVILIVVGVCAVFLKPGTMSLTEFGMLTSAAAVTLIEGAAGRIWNATTAVAMCHLLRKNWLAGASLAWTISRNLQSGALRRGGGRGRMLGEMWKAQLNQLTRQEFMEYRRDGIIEVDRSAARKARREGNVTGGHPVSRGTAKLRWMVERGFVKPHGKVIDLGCGRGGWSYYCATLKLVQEVKGYTKGGPGHEEPVMMQSYGWNLVSLKSGVDVFYRPSEQSDTLLCDIGEASPVPEIEEARTVKVLQMVEEWLSRGVEDFCVKILCPYMPKVLKELEKMQLRWGGGLIRVPLSRNSNHEMYWVSGASGNITNSVNTVSQMLINRMNRTNRNGPKYEEDVHLGSGTRAVVTKKIKTNWKMVEDRVKKLADEFSTTWHYDSEHPYKTWNYHGSYEVKATGSASSMVNGVVRVLSKPWDTLQSVVNMAMTDTTPFGQQRVFKEKVDTKAPEPPKGTAEVMRVTAKWMWKFVGRSKTPRVCTKEEFIAKVNSHAALGAIFKEQNRWASAREAVEDPAFWEMVDREREAHLQGRCEMCTYNMMGKREKKMGEFGKAKGSRAIWYMWLGSRYLEFEALGFLNEDHWMSRENTLGGVEGLGLQKLGYVLRDIAKNPGGLMYADDTAGWDTRITKADLENESIVLEMMTPEHRALAEPLIKFAYMNKVVKVMRPGADGITVMDVISREDQRGSGQVVTYALNTFTNLCVQLIRCMEGEGLLKPEEVEKLERGKQRKIQDWLDKNGTERLASMAVSGDDCVVKPKDDRFATALHFLNSMSKIRKDIPEWKQSTGWRNWQDVPFCSHHFHELTMKDGRQIVVPCRHQDELIGRARLSPGSGWSLTETACLSKAYGQMWLLMYFHRRDLRLMANAICSAVPVSWVPTGRTTWSIHGKGEWMTTEDMLRVWNRVWIEENEHMEDKTPVSSWNDVPYLGKREDSWCGSLIGHRARSTWAENIYTPIMQIRGLIGPERYVDYMPTLNRFKAVESWSEGVL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KF917539
EMBL· GenBank· DDBJ
AIU94743.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

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