A0A0C4MIE1 · A0A0C4MIE1_9NEOP

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    CO1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespirasome
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processoxidative phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      CO1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • M14
    • M25
    • M27
    • M43
    • M44
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Paraneoptera > Thysanoptera > Terebrantia > Thripoidea > Thripidae > Thrips

Accessions

  • Primary accession
    A0A0C4MIE1

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane23-49Helical
Transmembrane70-87Helical
Transmembrane115-139Helical
Transmembrane151-178Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-188Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    188
  • Mass (Da)
    20,678
  • Last updated
    2015-04-29 v1
  • Checksum
    AE554DDF0DF5C546
SLSMIIRLNLRTSMKLFISNDQFYNSIVTAHAFVMIFFTVMPIMIGGFGNWLVPLMLGAPDMAFPRLNNMSFWLLPPSLGLLIMGLYKEGAGTGWTVYPPLSTFYHSGPSVDLTIFSLHLAGISSILGALNFITTIINLKAKNLSAEKISLFVWSVILTAILLLLSLPVLAGAITMLLTDRNLNTSFF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue188

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KF640664
EMBL· GenBank· DDBJ
AIL94196.1
EMBL· GenBank· DDBJ
Genomic DNA
KF640665
EMBL· GenBank· DDBJ
AIL94197.1
EMBL· GenBank· DDBJ
Genomic DNA
KF640666
EMBL· GenBank· DDBJ
AIL94198.1
EMBL· GenBank· DDBJ
Genomic DNA
KF640667
EMBL· GenBank· DDBJ
AIL94199.1
EMBL· GenBank· DDBJ
Genomic DNA
KF640668
EMBL· GenBank· DDBJ
AIL94200.1
EMBL· GenBank· DDBJ
Genomic DNA
KF640669
EMBL· GenBank· DDBJ
AIL94201.1
EMBL· GenBank· DDBJ
Genomic DNA
KF640670
EMBL· GenBank· DDBJ
AIL94202.1
EMBL· GenBank· DDBJ
Genomic DNA
KF640671
EMBL· GenBank· DDBJ
AIL94203.1
EMBL· GenBank· DDBJ
Genomic DNA
KF640672
EMBL· GenBank· DDBJ
AIL94204.1
EMBL· GenBank· DDBJ
Genomic DNA
KF640673
EMBL· GenBank· DDBJ
AIL94205.1
EMBL· GenBank· DDBJ
Genomic DNA
KF640674
EMBL· GenBank· DDBJ
AIL94206.1
EMBL· GenBank· DDBJ
Genomic DNA
KF640675
EMBL· GenBank· DDBJ
AIL94207.1
EMBL· GenBank· DDBJ
Genomic DNA
KF640677
EMBL· GenBank· DDBJ
AIL94209.1
EMBL· GenBank· DDBJ
Genomic DNA
KF640678
EMBL· GenBank· DDBJ
AIL94210.1
EMBL· GenBank· DDBJ
Genomic DNA
KF640679
EMBL· GenBank· DDBJ
AIL94211.1
EMBL· GenBank· DDBJ
Genomic DNA
KF640680
EMBL· GenBank· DDBJ
AIL94212.1
EMBL· GenBank· DDBJ
Genomic DNA
KF640681
EMBL· GenBank· DDBJ
AIL94213.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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