A0A0C4DG17 · A0A0C4DG17_HUMAN
- ProteinSmall ribosomal subunit protein uS2
- GeneRPSA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids300 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.
Miscellaneous
This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 120-121 | Cleavage; by ST3; site 1 | ||||
Sequence: AF | ||||||
Site | 138-139 | Cleavage; by ST3; site 2 | ||||
Sequence: PL |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosolic small ribosomal subunit | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Molecular Function | laminin binding | |
Molecular Function | laminin receptor activity | |
Molecular Function | structural constituent of ribosome | |
Biological Process | ribosomal small subunit assembly | |
Biological Process | translation |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameSmall ribosomal subunit protein uS2
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A0C4DG17
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: 67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Co-localizes with PPP1R16B in the cell membrane.
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 191 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Genetic variation databases
PTM/Processing
Features
Showing features for initiator methionine, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Initiator methionine | 1 | UniProt | Removed | ||||
Sequence: M | |||||||
Modified residue | 2 | UniProt | N-acetylserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 2 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 43 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 75 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 109 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 143 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 144 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 246 | PRIDE | Phosphothreonine | ||||
Sequence: T |
Post-translational modification
Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.
Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
Keywords
- PTM
Expression
Gene expression databases
Interaction
Subunit
Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 166-185 | Laminin-binding | ||||
Sequence: IPCNNKGAHSVGLMWWMLAR | ||||||
Domain | 207-300 | Small ribosomal subunit protein uS2 C-terminal | ||||
Sequence: YFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTATQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTDWS | ||||||
Region | 210-234 | Laminin-binding | ||||
Sequence: RDPEEIEKEEQAAAEKAVTKEEFQG | ||||||
Repeat | 235-237 | [DE]-W-[ST] 1 | ||||
Sequence: EWT | ||||||
Region | 247-300 | Laminin-binding | ||||
Sequence: QPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTDWS | ||||||
Repeat | 252-254 | [DE]-W-[ST] 2 | ||||
Sequence: DWS | ||||||
Repeat | 271-273 | [DE]-W-[ST] 3 | ||||
Sequence: DWS | ||||||
Region | 271-300 | Disordered | ||||
Sequence: DWSAQPATEDWSAAPTAQATEWVGATTDWS | ||||||
Repeat | 280-282 | [DE]-W-[ST] 4 | ||||
Sequence: DWS | ||||||
Repeat | 298-300 | [DE]-W-[ST] 5 | ||||
Sequence: DWS |
Sequence similarities
Belongs to the universal ribosomal protein uS2 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length300
- Mass (Da)33,314
- Last updated2015-04-01 v1
- Checksum65E68AA2EE32128E
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P08865 | RSSA_HUMAN | RPSA | 295 | ||
C9J9K3 | C9J9K3_HUMAN | RPSA | 263 | ||
F8WD59 | F8WD59_HUMAN | RPSA | 116 | ||
A0A8V8TMX1 | A0A8V8TMX1_HUMAN | RPSA | 274 | ||
A0A8V8TMZ8 | A0A8V8TMZ8_HUMAN | RPSA | 45 | ||
A0A8V8TMP3 | A0A8V8TMP3_HUMAN | RPSA | 194 | ||
A0A8V8TLA4 | A0A8V8TLA4_HUMAN | RPSA | 331 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC099332 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471055 EMBL· GenBank· DDBJ | EAW64585.1 EMBL· GenBank· DDBJ | Genomic DNA |