A0A0C3CBQ0 · A0A0C3CBQ0_OIDMZ
- ProteinAdenine deaminase
- GeneAAH1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids353 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.
Catalytic activity
- adenine + H2O + H+ = hypoxanthine + NH4+
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 20 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 22 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 212 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Active site | 215 | Proton donor | ||||
Sequence: E | ||||||
Site | 236 | Important for catalytic activity | ||||
Sequence: H | ||||||
Binding site | 293 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 294 | substrate | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Molecular Function | 2'-deoxyadenosine deaminase activity | |
Molecular Function | adenine deaminase activity | |
Molecular Function | adenosine deaminase activity | |
Molecular Function | zinc ion binding | |
Biological Process | adenine catabolic process | |
Biological Process | hypoxanthine salvage | |
Biological Process | nucleotide metabolic process | |
Biological Process | purine ribonucleoside monophosphate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenine deaminase
- EC number
- Short namesADE
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Leotiomycetes > Leotiomycetes incertae sedis > Myxotrichaceae > Oidiodendron
Accessions
- Primary accessionA0A0C3CBQ0
Proteomes
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 15-346 | Adenosine deaminase | ||||
Sequence: PKCEHHLHIEGSLSPTLLFRLAATNNIALPSPAIDPAFASPAALSTRYEQFSSLDDFLHYYFIGMSVLLSSADFESLAYEYFCRAHADGVHHAEIFFDPQAHTSRGVAYDTVVKGLSAAQERARKDFSISSKLILCFLRHLPAGDAKQTFNAAQALGHFSDGTVAGIGLDSSEVGFPPELFREVYISAKDGGIRRTAHAGEEGDASYISGALDNCHVERIDHGIRVVEDDVLMKRIARNKTLVTMCPLSNVRLRCVQSVSELPVRTFLDEGVRFSVNSDDPAYFGGYILDNYCAVQEAFNLTFKEWKYIADGAIEGSWCDEERKSALLQKVQ |
Sequence similarities
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length353
- Mass (Da)39,045
- Last updated2015-04-01 v1
- Checksum18D424192A889F1A
Keywords
- Technical term