A0A0C3CBQ0 · A0A0C3CBQ0_OIDMZ

Function

function

Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site, site.

135350100150200250300350
TypeIDPosition(s)Description
Binding site20Zn2+ (UniProtKB | ChEBI); catalytic
Binding site22Zn2+ (UniProtKB | ChEBI); catalytic
Binding site212Zn2+ (UniProtKB | ChEBI); catalytic
Active site215Proton donor
Site236Important for catalytic activity
Binding site293Zn2+ (UniProtKB | ChEBI); catalytic
Binding site294substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular Function2'-deoxyadenosine deaminase activity
Molecular Functionadenine deaminase activity
Molecular Functionadenosine deaminase activity
Molecular Functionzinc ion binding
Biological Processadenine catabolic process
Biological Processhypoxanthine salvage
Biological Processnucleotide metabolic process
Biological Processpurine ribonucleoside monophosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenine deaminase
  • EC number
  • Short names
    ADE
  • Alternative names
    • Adenine aminohydrolase
      (AAH
      )

Gene names

    • Name
      AAH1
    • ORF names
      OIDMADRAFT_170047

Organism names

  • Taxonomic identifier
  • Strain
    • Zn
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Leotiomycetes > Leotiomycetes incertae sedis > Myxotrichaceae > Oidiodendron

Accessions

  • Primary accession
    A0A0C3CBQ0

Proteomes

Subcellular Location

Cytoplasm
Nucleus

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain15-346Adenosine deaminase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    353
  • Mass (Da)
    39,045
  • Last updated
    2015-04-01 v1
  • Checksum
    18D424192A889F1A
MCLSSRTHDFLQALPKCEHHLHIEGSLSPTLLFRLAATNNIALPSPAIDPAFASPAALSTRYEQFSSLDDFLHYYFIGMSVLLSSADFESLAYEYFCRAHADGVHHAEIFFDPQAHTSRGVAYDTVVKGLSAAQERARKDFSISSKLILCFLRHLPAGDAKQTFNAAQALGHFSDGTVAGIGLDSSEVGFPPELFREVYISAKDGGIRRTAHAGEEGDASYISGALDNCHVERIDHGIRVVEDDVLMKRIARNKTLVTMCPLSNVRLRCVQSVSELPVRTFLDEGVRFSVNSDDPAYFGGYILDNYCAVQEAFNLTFKEWKYIADGAIEGSWCDEERKSALLQKVQALVAKYE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KN832884
EMBL· GenBank· DDBJ
KIM96383.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp