A0A0C2SI32 · A0A0C2SI32_CLOBO
- ProteinDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids362 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of dihydroorotate to orotate with NAD+ as electron acceptor.
Catalytic activity
- (S)-dihydroorotate + NAD+ = H+ + NADH + orotate
Cofactor
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (NAD+ route): step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | dihydroorotate dehydrogenase (NAD+) activity | |
Molecular Function | iron-sulfur cluster binding | |
Molecular Function | metal ion binding | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | pyrimidine nucleotide biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Bacillota > Clostridia > Eubacteriales > Clostridiaceae > Clostridium
Accessions
- Primary accessionA0A0C2SI32
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 305-332 | 4Fe-4S ferredoxin-type | ||||
Sequence: IPPKVNQDACIKCGICKTSCVYDAIEVS | ||||||
Domain | 333-362 | 4Fe-4S ferredoxin-type | ||||
Sequence: NELIIDSKKCFGCGLCVTRCPKNALSMQYK |
Sequence similarities
Belongs to the dihydropyrimidine dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length362
- Mass (Da)38,738
- Last updated2015-04-01 v1
- ChecksumEBA08F20801248A9