A0A0B7JF61 · A0A0B7JF61_9GAMM

  • Protein
    N-acetylmuramic acid 6-phosphate etherase
  • Gene
    yfeU
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.

Miscellaneous

A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation.
Amino-sugar metabolism; N-acetylmuramate degradation.
Cell wall biogenesis; peptidoglycan recycling.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site85Proton donor
Active site116

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncarbohydrate binding
Molecular Functioncarbon-oxygen lyase activity
Molecular Functionenzyme binding
Molecular Functionenzyme inhibitor activity
Molecular Functionfructose-6-phosphate binding
Biological Process1,6-anhydro-N-acetyl-beta-muramic acid catabolic process
Biological Processamino sugar catabolic process
Biological Processglucose homeostasis
Biological ProcessN-acetylmuramic acid catabolic process
Biological Processpeptidoglycan turnover
Biological Processresponse to fructose

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    N-acetylmuramic acid 6-phosphate etherase
  • EC number
  • Short names
    MurNAc-6-P etherase
  • Alternative names
    • N-acetylmuramic acid 6-phosphate hydrolase
    • N-acetylmuramic acid 6-phosphate lyase

Gene names

    • Name
      yfeU
    • Synonyms
      murQ
    • ORF names
      C9J27_19750
      , PPBDW_II1087

Organism names

  • Taxonomic identifier
  • Strains
    • ANT-2200
    • ANT220
    • FS-7.2
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Vibrionales > Vibrionaceae > Photobacterium

Accessions

  • Primary accession
    A0A0B7JF61
  • Secondary accessions
    • A0A2T3KD96

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain57-220SIS

Sequence similarities

Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    301
  • Mass (Da)
    31,358
  • Last updated
    2015-04-01 v1
  • Checksum
    8A6D252F15A0D7E3
MKIDLTHLVTESRNSASEAIDTLSTLDMLKVINDEDKKVALAVEQTLPAIAQAVDAIAAAFQNGGRLVYVGAGTSGRLGILDASECPPTYGSAPEQVVGLIAGGHQAILKAVENAEDNIEMGAEDLKAINFSARDVLVGIAASGRTPYVLGAMAYARSVNAIVACVSCNPQSPMTAAADIVITPVVGAEVVTGSSRMKAGTAQKLVLNMLTTGAMIRIGKIYGNLMVDVEATNAKLVERQKNIVMQATECDRAQAEAALDACNGHCKTAIVMILTGVNNVTAKTLLQQNNGYIRSAIAKNC

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CCAR020000009
EMBL· GenBank· DDBJ
CEO41756.1
EMBL· GenBank· DDBJ
Genomic DNA
PYNF01000024
EMBL· GenBank· DDBJ
PSU94311.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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