A0A0B5L385 · A0A0B5L385_9APIC

  • Protein
    Bifunctional dihydrofolate reductase-thymidylate synthase
  • Gene
    DHFR-TS
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.

Features

Showing features for active site.

163750100150200250300350400450500550600
TypeIDPosition(s)Description
Active site519

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functiondihydrofolate reductase activity
Molecular Functionthymidylate synthase activity
Biological ProcessdTMP biosynthetic process
Biological Processmethylation
Biological Processone-carbon metabolic process
Biological Processtetrahydrofolate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional dihydrofolate reductase-thymidylate synthase
  • EC number

Gene names

    • Name
      DHFR-TS

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Po2014-1
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Plasmodium)

Accessions

  • Primary accession
    A0A0B5L385

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain9-233DHFR
Region236-262Disordered
Compositional bias243-262Polar residues

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    637
  • Mass (Da)
    73,864
  • Last updated
    2015-04-01 v1
  • Checksum
    33A654B51F412822
MEEVCEVFDIYAICSCCKVSKEGDWKKSESYSNSTFRGIGNKGILPWKYNSVDISYFRSVTTYVNEWNYNKLKYKREKYLEKDISNDKKKVDVINIAPISKKLQNVVVMGRSSWESIPKSYKPLANRINVVLSSTLKKEDVKEDIFIMKSMDEVLLLLKKLYYYKCFIIGGAGVYKECLERNLIKQVYLTRINNTYECDVFFPEMDKNTFQITSVSEVYSSNGTTLDFLIYSRKKKDTQNDGDSSEGSTTTTATATWPGIAGDTTSMNIAETSTTYASSHHGKGSSKWWTKVCTKSGAEWWKNMTLTSQGKDNVDEEDDYMYFSFNNKKKKSQIGKNAEDFEIYNTIKLKQHPEYQYLNIIYDVMINGNKQDDRTGVGVLSKFGYMMKYNLAEYFPLLTTKKLFIRGIIEELLWFIRGETNGNILLNKNVRIWEANGTREFLDNRNLFDREVNDLGPIYGFQWRHFGAEYTNMYDNYDNKGIDQLKNIINLIKNEPLSRRIILCAWNVKDLDKMALPPCHILCQFYIFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTYMLAQVCNLQPAEFIHVLGNAHIYNNHIDSLKIQLNRIPYPFPTLKLNPEIKNIEDFTISDFTIENYVHHDKITMDMAA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias243-262Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KP050414
EMBL· GenBank· DDBJ
AJG43686.1
EMBL· GenBank· DDBJ
mRNA

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