both vIL-6 and VKORC1v2 interact with calnexin cycle proteins UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1) which catalyzes monoglucosylation of N-glycans and oppositely acting glucosidase II (GlucII) and that vIL-6 can promote protein folding.
The vitamin K oxidoreductase is a multimer that efficiently reduces vitamin K epoxide to hydroquinone to allow vitamin K-dependent protein carboxylation.
gp130 signaling was unaffected by VKORC1v2 or vBD overexpression or by VKORC1v2 depletion suggesting an alternative pathway of vIL-6 activity via VKORC1v2
Report VKORC1 itself its paralog VKORC1L1 emopamil binding protein (EBP) and stress-associated endoplasmic reticulum protein 1 (SERP1) as interaction partners for VKORC1.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.