lack of ChChd3 leads to inactivation of Hippo activity under normal development which is also dependent on the transcriptional coactivator Yorkie (Yki). Furthermore loss of ChChd3 induces oxidative stress and activates the JNK pathway. In addition depletion of other mitochondrial fusion components Opa1 or Marf inactivates the Hippo pathway as well.
these results suggest that rho-7 and Opa1-like function in a common molecular pathway affecting mitochondrial function and apoptosis in Drosophila melanogaster.
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