A0A0B4LFF8 · A0A0B4LFF8_DROME
- ProteinRho guanine nucleotide exchange factor 2, isoform H
- GeneRhoGEF2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2456 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionA0A0B4LFF8
Proteomes
Organism-specific databases
PTM/Processing
Keywords
- PTM
Expression
Gene expression databases
Family & Domains
Features
Showing features for compositional bias, region, domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-17 | Basic and acidic residues | ||||
Sequence: MDDPSIKKRLLDLYTDE | ||||||
Region | 1-251 | Disordered | ||||
Sequence: MDDPSIKKRLLDLYTDEHEYDEVQEIPEESSIQPPETSTSHTSTNGSSHSGPGTATGPGATSAGPSAGAPQSPVIVVDSVPELPAPKQKSVKNSKSKQKQKQLANKSKIPRSPSLASSLSSLASSLSGHRDRDKDRDKDRENQNAVPPQTPPLPPSYKQNQMNGDSTAAAGGGVSAPATPTTANNNNASHNNGSIMGGGVQLNQSDNSNPVLQAPGERSSLNLTPLSRDLSGGHTQESTTPATTPSTPSLA | ||||||
Compositional bias | 30-68 | Polar residues | ||||
Sequence: SSIQPPETSTSHTSTNGSSHSGPGTATGPGATSAGPSAG | ||||||
Compositional bias | 105-126 | Polar residues | ||||
Sequence: NKSKIPRSPSLASSLSSLASSL | ||||||
Compositional bias | 127-143 | Basic and acidic residues | ||||
Sequence: SGHRDRDKDRDKDRENQ | ||||||
Compositional bias | 177-251 | Polar residues | ||||
Sequence: PATPTTANNNNASHNNGSIMGGGVQLNQSDNSNPVLQAPGERSSLNLTPLSRDLSGGHTQESTTPATTPSTPSLA | ||||||
Domain | 260-336 | PDZ | ||||
Sequence: TLTVRKDSNGYGMKVSGDNPVFVESVKPGGAAEIAGLVAGDMILRVNGHEVRLEKHPTVVGLIKASTTVELAVKRSQ | ||||||
Region | 343-367 | Disordered | ||||
Sequence: SVSVVTPSTPILSGRDRTASITGPQ | ||||||
Region | 424-567 | Disordered | ||||
Sequence: QVGAEQQRMSHQAESMSQSMHQHTSTPTSQQFFHPHQQQHRFKETGPTSKGKNKFLISRSLIEEDVPPPLPQRNPPRQLNLDLKNGNASPGGSHLVAPVSDLDRATSPQLNRSQQQQLPSSTDNSPSNAKSKRSKIKTKALSDP | ||||||
Compositional bias | 426-459 | Polar residues | ||||
Sequence: GAEQQRMSHQAESMSQSMHQHTSTPTSQQFFHPH | ||||||
Compositional bias | 527-554 | Polar residues | ||||
Sequence: RATSPQLNRSQQQQLPSSTDNSPSNAKS | ||||||
Compositional bias | 665-685 | Polar residues | ||||
Sequence: QQQQQHQMSGGQATGALGQTP | ||||||
Region | 665-758 | Disordered | ||||
Sequence: QQQQQHQMSGGQATGALGQTPNLGKNKHRRVGSSPDNMHPRHPDRITKTTSGSWEIVEKDGESSPPGTPPPPYLSSSHMTVLEDPNENNRGAAA | ||||||
Compositional bias | 693-712 | Basic and acidic residues | ||||
Sequence: RRVGSSPDNMHPRHPDRITK | ||||||
Domain | 1047-1097 | Phorbol-ester/DAG-type | ||||
Sequence: GHPLVLRQYYEVTHCNHCQTIIWGVSPQGYHCTDCKLNIHRQCSKVVDESC | ||||||
Compositional bias | 1130-1145 | Basic and acidic residues | ||||
Sequence: NEKRSRQDEELDVELT | ||||||
Region | 1130-1180 | Disordered | ||||
Sequence: NEKRSRQDEELDVELTPDRGQASIVRQPSDRRPDANISIRSNGNTSCNTSG | ||||||
Compositional bias | 1163-1180 | Polar residues | ||||
Sequence: DANISIRSNGNTSCNTSG | ||||||
Region | 1247-1300 | Disordered | ||||
Sequence: RRERYSQHPKHKSAPVSVNRSESYKERLSNKRNRNSRRKTSDPSLSSRPNDEQL | ||||||
Compositional bias | 1270-1291 | Basic and acidic residues | ||||
Sequence: YKERLSNKRNRNSRRKTSDPSL | ||||||
Compositional bias | 1312-1330 | Polar residues | ||||
Sequence: SSNSSLSSAGGSESPSTSM | ||||||
Region | 1312-1340 | Disordered | ||||
Sequence: SSNSSLSSAGGSESPSTSMEHFAAPGAAG | ||||||
Coiled coil | 1422-1449 | |||||
Sequence: AAEVLAALTDAEKKRQEIINEIYQTERN | ||||||
Domain | 1435-1630 | DH | ||||
Sequence: KRQEIINEIYQTERNHVRTLKLLDRLFFLPLYESGLLSQDHLLLLFPPALLSLREIHGAFEQSLKQRRIEHNHVVNTIGDLLADMFDGQSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQKLLKKSESHKACRRLELKDLLPTVLQRLTKYPLLFENLYKVTVRLLPENTTEAEAIQRAVESSKRILVEVNQA | ||||||
Compositional bias | 1775-1792 | Polar residues | ||||
Sequence: QSKNRSKNASSNHDTSIS | ||||||
Region | 1775-1795 | Disordered | ||||
Sequence: QSKNRSKNASSNHDTSISDPA | ||||||
Region | 1840-1894 | Disordered | ||||
Sequence: PAPATNNSNVSSLTGVQLRNPQRDATASESDADYVNTPKPRSSQNEVNRTMSIRS | ||||||
Region | 1912-1943 | Disordered | ||||
Sequence: VTLRHSQSTRESVRPGSTGEERNSTYGMVGGN | ||||||
Region | 2087-2122 | Disordered | ||||
Sequence: LRKKVAPSSSFSSSPPPLPPPNRQHAQAQAQIPPSR | ||||||
Region | 2151-2326 | Disordered | ||||
Sequence: RLPAIPSKPHERPTTPLAPFNTEPKTSQSVIDASKRQSTDAVPEGLLEQEPLEGDKTETKGEDNEVKTVPSDKLSESCNEERQCVEADITKEVADPTTSKNEAAASVDELPSQSREIKTAENASKSVADKKEDNEETIEEGVASTVDSSTQTSPTESPKETDKLTGGSSSTCGPNR | ||||||
Compositional bias | 2169-2186 | Polar residues | ||||
Sequence: PFNTEPKTSQSVIDASKR | ||||||
Compositional bias | 2199-2245 | Basic and acidic residues | ||||
Sequence: QEPLEGDKTETKGEDNEVKTVPSDKLSESCNEERQCVEADITKEVAD | ||||||
Compositional bias | 2246-2271 | Polar residues | ||||
Sequence: PTTSKNEAAASVDELPSQSREIKTAE | ||||||
Compositional bias | 2272-2288 | Basic and acidic residues | ||||
Sequence: NASKSVADKKEDNEETI | ||||||
Compositional bias | 2291-2326 | Polar residues | ||||
Sequence: GVASTVDSSTQTSPTESPKETDKLTGGSSSTCGPNR | ||||||
Coiled coil | 2360-2387 | |||||
Sequence: INERDMERERLRKENQHLRELLSALHDR | ||||||
Region | 2415-2456 | Disordered | ||||
Sequence: IDAISNSSLTPTPTPIPTASPSASGQVETAEAMRITSTEDEE | ||||||
Compositional bias | 2417-2447 | Polar residues | ||||
Sequence: AISNSSLTPTPTPIPTASPSASGQVETAEAM |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,456
- Mass (Da)269,559
- Last updated2015-04-01 v1
- ChecksumB958C362CF326394
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A1ZAN6 | A1ZAN6_DROME | RhoGEF2 | 2559 | ||
A0A0B4K7T7 | A0A0B4K7T7_DROME | RhoGEF2 | 2557 | ||
A1ZAN7 | A1ZAN7_DROME | RhoGEF2 | 2205 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-17 | Basic and acidic residues | ||||
Sequence: MDDPSIKKRLLDLYTDE | ||||||
Compositional bias | 30-68 | Polar residues | ||||
Sequence: SSIQPPETSTSHTSTNGSSHSGPGTATGPGATSAGPSAG | ||||||
Compositional bias | 105-126 | Polar residues | ||||
Sequence: NKSKIPRSPSLASSLSSLASSL | ||||||
Compositional bias | 127-143 | Basic and acidic residues | ||||
Sequence: SGHRDRDKDRDKDRENQ | ||||||
Compositional bias | 177-251 | Polar residues | ||||
Sequence: PATPTTANNNNASHNNGSIMGGGVQLNQSDNSNPVLQAPGERSSLNLTPLSRDLSGGHTQESTTPATTPSTPSLA | ||||||
Compositional bias | 426-459 | Polar residues | ||||
Sequence: GAEQQRMSHQAESMSQSMHQHTSTPTSQQFFHPH | ||||||
Compositional bias | 527-554 | Polar residues | ||||
Sequence: RATSPQLNRSQQQQLPSSTDNSPSNAKS | ||||||
Compositional bias | 665-685 | Polar residues | ||||
Sequence: QQQQQHQMSGGQATGALGQTP | ||||||
Compositional bias | 693-712 | Basic and acidic residues | ||||
Sequence: RRVGSSPDNMHPRHPDRITK | ||||||
Compositional bias | 1130-1145 | Basic and acidic residues | ||||
Sequence: NEKRSRQDEELDVELT | ||||||
Compositional bias | 1163-1180 | Polar residues | ||||
Sequence: DANISIRSNGNTSCNTSG | ||||||
Compositional bias | 1270-1291 | Basic and acidic residues | ||||
Sequence: YKERLSNKRNRNSRRKTSDPSL | ||||||
Compositional bias | 1312-1330 | Polar residues | ||||
Sequence: SSNSSLSSAGGSESPSTSM | ||||||
Compositional bias | 1775-1792 | Polar residues | ||||
Sequence: QSKNRSKNASSNHDTSIS | ||||||
Compositional bias | 2169-2186 | Polar residues | ||||
Sequence: PFNTEPKTSQSVIDASKR | ||||||
Compositional bias | 2199-2245 | Basic and acidic residues | ||||
Sequence: QEPLEGDKTETKGEDNEVKTVPSDKLSESCNEERQCVEADITKEVAD | ||||||
Compositional bias | 2246-2271 | Polar residues | ||||
Sequence: PTTSKNEAAASVDELPSQSREIKTAE | ||||||
Compositional bias | 2272-2288 | Basic and acidic residues | ||||
Sequence: NASKSVADKKEDNEETI | ||||||
Compositional bias | 2291-2326 | Polar residues | ||||
Sequence: GVASTVDSSTQTSPTESPKETDKLTGGSSSTCGPNR | ||||||
Compositional bias | 2417-2447 | Polar residues | ||||
Sequence: AISNSSLTPTPTPIPTASPSASGQVETAEAM |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE013599 EMBL· GenBank· DDBJ | AHN56311.1 EMBL· GenBank· DDBJ | Genomic DNA |