A0A0B4KGY6 · NOVA_DROME

Function

function

Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion (By similarity).
Plays a role in long-term memory formation by processing the unspliced Orb2-isoform A (Orb2A) mRNA and thereby controlling Orb2A protein abundance (PubMed:28525754).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular FunctionmRNA binding
Molecular Functionpre-mRNA intronic binding
Biological ProcessmRNA splicing, via spliceosome
Biological Processpositive regulation of RNA splicing
Biological Processregulation of alternative mRNA splicing, via spliceosome

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    RNA-binding protein Pasilla

Gene names

    • Name
      ps
    • Synonyms
      l(3)10615
      , NOVA1
    • ORF names
      CG42670

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    A0A0B4KGY6
  • Secondary accessions
    • A0A0B4JCX5
    • A0A0B4KFY5
    • A0A0B4LGY5
    • A0A0B4LI06
    • Q0KI94

Proteomes

Organism-specific databases

Subcellular Location

Nucleus
Cytoplasm
Note: Localizes to synaptoneuropil region of neurons.

Keywords

Phenotypes & Variants

Disruption phenotype

In both embryo and larva, results in irregularly shaped salivary glands with bulges of variable sizes, leading to greater distances between neighboring nuclei and decreased apical secretion.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis466In both embryo and larva, results in irregularly shaped salivary glands with bulges of variable sizes, leading to greater distances between neighboring nuclei.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004534551-780RNA-binding protein Pasilla

Proteomic databases

Expression

Tissue specificity

Expressed in the central nervous system in mushroom body neurons (at protein level).

Developmental stage

Expressed in the salivary gland, anterior and posterior midgut primordia, the fully formed midgut, amnioserosa, malpighian tubules, several regions of the head, and in isolated cells along the germ band, which are likely to be hemocytes.

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region31-50Disordered
Region76-113Disordered
Region150-190Disordered
Compositional bias168-190Polar residues
Domain273-340KH 1
Domain366-432KH 2
Compositional bias674-691Polar residues
Region674-693Disordered
Region686-776Required for RNA binding
Domain691-758KH 3

Domain

The KH domain consists of approximately 70 amino acids and includes a conserved hydrophobic core, an invariant Gly-X-X-Gly motif, and an additional variable segment. The third KH domain (KH3) binds a hairpin RNA loop containing the 5'-UCAY-3' motif on targeted molecules. RNA binding by KH3 requires residues C-terminal to the KH domain.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

  • Sequence status
    Complete

This entry describes 12 isoforms produced by Alternative splicing.

A0A0B4KGY6-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    780
  • Mass (Da)
    81,403
  • Last updated
    2015-04-01 v1
  • Checksum
    9073B1B1A7081057
MESIMKVAMDKAAEQLIQQFGFDYLQQQLQLQHQNQHNSSPQQPQHQQLEPENEHLTYQYQQSKPTHMQQLACNYQPRHSTTTSSPSSTHSLASGGGSSSNSSNSSSSDSSSINISHISNISNISNIGNISNSNHSNAAYSLAVHSYQKQIESPANPSHVPHHQMDLSPLSENGSPNGTPGAQTPTATASGNTAAALASAAAAAAAATSGGNGSSITNCNSNNSSSSSNAQQQLQLGNYKTNSCWCYGESVCSGIEVEIENNNNNHIHHGETTYHMKILVPAVASGAIIGKGGETIASLQKDTGARVKMSKSHDFYPGTTERVCLITGSTEAIMVVMEFIMDKIREKPDLTNKIVDTDSKQTQERDKQVKILVPNSTAGMIIGKGGAFIKQIKEESGSYVQISQKPTDVSLQERCITIIGDKENNKNACKMILSKIVEDPQSGTCLNVSYADVSGPVANFNPTGSPYATNQNAINSSTASLNSTLGTTIGGANSAASLLVNGTGINLSINLGSPNPAPNLAVATQLLEHIKVAMRGSGYSETVTNEVVAALSVLAKYGVLGMGVGVSHTNGAHSTLGNFLGVTTLDQQTAAAASAATASNVFGAVGQVNLEQYAAAVASAAAASRPTQSQLDAAAVQFDPFRHLGSATAPAATPVSLNNNSFGLTATTGTATTAQLGGLSKSPTPGDLSSKDSKNVEVPEVIIGAILGPSGRSLVEIQHVSGANVQISKKGIFAPGTRNRIVTITGQPSAIAKAQYLIEQKINEEETKRARQIPLTTVVN

A0A0B4KGY6-9

  • Name
    B
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-248: MESIMKVAMDKAAEQLIQQFGFDYLQQQLQLQHQNQHNSSPQQPQHQQLEPENEHLTYQYQQSKPTHMQQLACNYQPRHSTTTSSPSSTHSLASGGGSSSNSSNSSSSDSSSINISHISNISNISNIGNISNSNHSNAAYSLAVHSYQKQIESPANPSHVPHHQMDLSPLSENGSPNGTPGAQTPTATASGNTAAALASAAAAAAAATSGGNGSSITNCNSNNSSSSSNAQQQLQLGNYKTNSCWCYG → MRKLCSS
    • 709-716: PSGRSLVE → ARPYYYPY
    • 717-780: Missing

A0A0B4KGY6-8

  • Name
    C
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-270: MESIMKVAMDKAAEQLIQQFGFDYLQQQLQLQHQNQHNSSPQQPQHQQLEPENEHLTYQYQQSKPTHMQQLACNYQPRHSTTTSSPSSTHSLASGGGSSSNSSNSSSSDSSSINISHISNISNISNIGNISNSNHSNAAYSLAVHSYQKQIESPANPSHVPHHQMDLSPLSENGSPNGTPGAQTPTATASGNTAAALASAAAAAAAATSGGNGSSITNCNSNNSSSSSNAQQQLQLGNYKTNSCWCYGESVCSGIEVEIENNNNNHIHHG → MLFARTTSSTSISPPAMMMQQHQQQQQQQDPQKLGQQFHQQPAFQLQQSFC

A0A0B4KGY6-2

  • Name
    D
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-248: MESIMKVAMDKAAEQLIQQFGFDYLQQQLQLQHQNQHNSSPQQPQHQQLEPENEHLTYQYQQSKPTHMQQLACNYQPRHSTTTSSPSSTHSLASGGGSSSNSSNSSSSDSSSINISHISNISNISNIGNISNSNHSNAAYSLAVHSYQKQIESPANPSHVPHHQMDLSPLSENGSPNGTPGAQTPTATASGNTAAALASAAAAAAAATSGGNGSSITNCNSNNSSSSSNAQQQLQLGNYKTNSCWCYG → MLFARTTSSTSISPPAMMMQQHQQQQQQQDPQKLGQQFHQQPAFQLQQSFC

A0A0B4KGY6-3

  • Name
    F
  • Synonyms
    G
    , H
    , N
    , O
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-247: MESIMKVAMDKAAEQLIQQFGFDYLQQQLQLQHQNQHNSSPQQPQHQQLEPENEHLTYQYQQSKPTHMQQLACNYQPRHSTTTSSPSSTHSLASGGGSSSNSSNSSSSDSSSINISHISNISNISNIGNISNSNHSNAAYSLAVHSYQKQIESPANPSHVPHHQMDLSPLSENGSPNGTPGAQTPTATASGNTAAALASAAAAAAAATSGGNGSSITNCNSNNSSSSSNAQQQLQLGNYKTNSCWCY → MAEDATMETCPSPETGDSRKRPLDSDPENEQTKRSHFSS

A0A0B4KGY6-5

  • Name
    I
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-248: MESIMKVAMDKAAEQLIQQFGFDYLQQQLQLQHQNQHNSSPQQPQHQQLEPENEHLTYQYQQSKPTHMQQLACNYQPRHSTTTSSPSSTHSLASGGGSSSNSSNSSSSDSSSINISHISNISNISNIGNISNSNHSNAAYSLAVHSYQKQIESPANPSHVPHHQMDLSPLSENGSPNGTPGAQTPTATASGNTAAALASAAAAAAAATSGGNGSSITNCNSNNSSSSSNAQQQLQLGNYKTNSCWCYG → MLFARTTSSTSISPPAMMMQQHQQQQQQQDPQKLGQQFHQQPAFQLQQSFC
    • 709-716: PSGRSLVE → ARPYYYPY
    • 717-780: Missing

A0A0B4KGY6-4

  • Name
    J
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-248: MESIMKVAMDKAAEQLIQQFGFDYLQQQLQLQHQNQHNSSPQQPQHQQLEPENEHLTYQYQQSKPTHMQQLACNYQPRHSTTTSSPSSTHSLASGGGSSSNSSNSSSSDSSSINISHISNISNISNIGNISNSNHSNAAYSLAVHSYQKQIESPANPSHVPHHQMDLSPLSENGSPNGTPGAQTPTATASGNTAAALASAAAAAAAATSGGNGSSITNCNSNNSSSSSNAQQQLQLGNYKTNSCWCYG → MRKLCSS

A0A0B4KGY6-6

A0A0B4KGY6-7

  • Name
    M
  • Synonyms
    K
    , P
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-269: MESIMKVAMDKAAEQLIQQFGFDYLQQQLQLQHQNQHNSSPQQPQHQQLEPENEHLTYQYQQSKPTHMQQLACNYQPRHSTTTSSPSSTHSLASGGGSSSNSSNSSSSDSSSINISHISNISNISNIGNISNSNHSNAAYSLAVHSYQKQIESPANPSHVPHHQMDLSPLSENGSPNGTPGAQTPTATASGNTAAALASAAAAAAAATSGGNGSSITNCNSNNSSSSSNAQQQLQLGNYKTNSCWCYGESVCSGIEVEIENNNNNHIHH → MAEDATMETCPSPETGDSRKRPLDSDPENEQTKRSHFSS

A0A0B4KGY6-10

  • Name
    Q
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-270: MESIMKVAMDKAAEQLIQQFGFDYLQQQLQLQHQNQHNSSPQQPQHQQLEPENEHLTYQYQQSKPTHMQQLACNYQPRHSTTTSSPSSTHSLASGGGSSSNSSNSSSSDSSSINISHISNISNISNIGNISNSNHSNAAYSLAVHSYQKQIESPANPSHVPHHQMDLSPLSENGSPNGTPGAQTPTATASGNTAAALASAAAAAAAATSGGNGSSITNCNSNNSSSSSNAQQQLQLGNYKTNSCWCYGESVCSGIEVEIENNNNNHIHHG → MRKLCSS

A0A0B4KGY6-12

A0A0B4KGY6-11

  • Name
    T
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0611441-164in isoform T and isoform S
Alternative sequenceVSP_0611431-247in isoform F
Alternative sequenceVSP_0611411-248in isoform D and isoform I
Alternative sequenceVSP_0611421-248in isoform J and isoform B
Alternative sequenceVSP_0611401-269in isoform M
Alternative sequenceVSP_0611381-270in isoform C
Alternative sequenceVSP_0611391-270in isoform Q
Compositional bias168-190Polar residues
Alternative sequenceVSP_061145248-269in isoform L and isoform S
Compositional bias674-691Polar residues
Alternative sequenceVSP_061146709-716in isoform I and isoform B
Alternative sequenceVSP_061147717-780in isoform I and isoform B

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF220420
EMBL· GenBank· DDBJ
AAG36787.1
EMBL· GenBank· DDBJ
mRNA
AF220421
EMBL· GenBank· DDBJ
AAG36788.1
EMBL· GenBank· DDBJ
mRNA
AF220422
EMBL· GenBank· DDBJ
AAG36789.1
EMBL· GenBank· DDBJ
mRNA
AF220423
EMBL· GenBank· DDBJ
AAG36790.1
EMBL· GenBank· DDBJ
mRNA
AE014297
EMBL· GenBank· DDBJ
AAF54377.3
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
AAF54378.2
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
AAN13424.2
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
AAN13425.2
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
AAN13427.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
AAN13428.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
ABI31151.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
ABI31152.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
ABI31154.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
ADV37290.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
ADV37291.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
ADV37292.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
ADV37293.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
ADV37294.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
AGB95796.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
AGB95797.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
AHN57251.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014297
EMBL· GenBank· DDBJ
AHN57252.1
EMBL· GenBank· DDBJ
Genomic DNA
AY089247
EMBL· GenBank· DDBJ
AAL89985.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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