A0A0B4K6U3 · A0A0B4K6U3_DROME
- Proteinprotein kinase C
- GenePkn
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1260 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cleavage furrow | |
Cellular Component | midbody | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | diacylglycerol-dependent serine/threonine kinase activity | |
Molecular Function | protein serine kinase activity | |
Molecular Function | small GTPase binding | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameprotein kinase C
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionA0A0B4K6U3
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Keywords
- PTM
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, coiled coil, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 28-102 | REM-1 | ||||
Sequence: NLPESCMSIRLEEIKEAIRREIRKELKIKEGAEKLREVAKDRRSLSDVAVLVKKSKSKLAELKSELQELESQILL | ||||||
Coiled coil | 79-106 | |||||
Sequence: VKKSKSKLAELKSELQELESQILLTSAN | ||||||
Domain | 142-219 | REM-1 | ||||
Sequence: ALEGGAPATANDKVLASLEKQLQIEMKVKTGAENMIQSLGIGCDKKLLAEAHQMLADSKAKIEFLRLRIIKVKQNREQ | ||||||
Coiled coil | 189-216 | |||||
Sequence: LAEAHQMLADSKAKIEFLRLRIIKVKQN | ||||||
Domain | 242-322 | REM-1 | ||||
Sequence: SSQPQSLETTLEERIEELRHRLRIEAAVVDGAKNVIRTLQTANRAPDKKALQEAHGRLSESSRKLDLLRYSLDLRRQELPA | ||||||
Domain | 359-515 | C2 | ||||
Sequence: LGGKPYQSVSSLGRCASVTGKLEVRLLGCQDLLEDVPGRSRRDKDNNSSPGDLRSFVKGVTSRSSSKSYSVKDETSIEIMAVIKLDNITVGQTSWKQCSQQAWDQRFSIDLDRSRELEIGVYWRDWRSLCAVKVLRLEEFIDDVRHGMALQLEPQGL | ||||||
Region | 395-415 | Disordered | ||||
Sequence: PGRSRRDKDNNSSPGDLRSFV | ||||||
Region | 572-715 | Disordered | ||||
Sequence: HVHMGSAGSGSSLTGSSPMVVGGSRDSESPISRTPSSDALVEPEPYTPGEQAQNLEFDPDAGINEHVETPGEYPDPAASGLSGMRPLSMHMQGISVLPPESPPVATGAAGRPNTLSLQMPGASKGQVIQGGRTAAPTTAPPPPP | ||||||
Compositional bias | 575-607 | Polar residues | ||||
Sequence: MGSAGSGSSLTGSSPMVVGGSRDSESPISRTPS | ||||||
Region | 827-857 | Disordered | ||||
Sequence: PATPTIYGNSAAAGAPQFPQPAQRQEKQPPQ | ||||||
Region | 881-902 | Disordered | ||||
Sequence: SPSSSTTSNSNQQQQQQRRNVA | ||||||
Domain | 933-1192 | Protein kinase | ||||
Sequence: FRLLSVLGRGHFGKVILSQLRSNNQYYAIKALKKGDIIARDEVESLLSEKRIFEVANAMRHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHIHTDVFLEPRAVFYAACVVLGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTGTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSLEAIAVMRRLLRKNPERRLGSSERDAEDVKKQAFF | ||||||
Domain | 1193-1260 | AGC-kinase C-terminal | ||||
Sequence: RSIVWDDLLLRKVKPPFVPTINHLEDVSNFDEEFTSEKAQLTPPKEPRHLTEEEQLLFQDFSYTAEWC |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,260
- Mass (Da)139,345
- Last updated2015-04-01 v1
- Checksum51FA8BA39F88186D
Computationally mapped potential isoform sequences
There are 13 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A1Z7T0 | PKN_DROME | Pkn | 1190 | ||
A0A0B4JD07 | A0A0B4JD07_DROME | Pkn | 1354 | ||
A0A0B4K727 | A0A0B4K727_DROME | Pkn | 1275 | ||
A0A0B4LF03 | A0A0B4LF03_DROME | Pkn | 1278 | ||
A8DY76 | A8DY76_DROME | Pkn | 1501 | ||
A0A0B4LEY5 | A0A0B4LEY5_DROME | Pkn | 1167 | ||
A0A0B4LEI8 | A0A0B4LEI8_DROME | Pkn | 1280 | ||
A0A0B4LFX2 | A0A0B4LFX2_DROME | Pkn | 1477 | ||
E1JH15 | E1JH15_DROME | Pkn | 1284 | ||
A1Z7T1 | A1Z7T1_DROME | Pkn | 1407 | ||
A1Z7T2 | A1Z7T2_DROME | Pkn | 1205 | ||
A1Z7T3 | A1Z7T3_DROME | Pkn | 1422 | ||
A1Z7T4 | A1Z7T4_DROME | Pkn | 590 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 575-607 | Polar residues | ||||
Sequence: MGSAGSGSSLTGSSPMVVGGSRDSESPISRTPS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE013599 EMBL· GenBank· DDBJ | AFH07975.1 EMBL· GenBank· DDBJ | Genomic DNA |